<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10579

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAMSYGWPRVGGPPSAGDPSMNHIYPTPPSVQSEAQQFSPAPVLPPHSTVINTNQARHISVYLSVVLDTTLMNIASQHQLIIMNAKTEPQIPEPLQEMEDDEQKPLVPLGSTMDKLLNRINNTPVSGYVRKQIVPSSSRFSAVEDKVALCSAIAHRRGPVHMPPDYHKPVSNLDKRVPKQLSVELLLSFPSNIPSTAPSQMTPVTSFSNPGYKPNFGAISGATTTTSSLPSMGAIPPMQHQQITGFPNSQIRTPPMIMGRSITSHGLYGTPTPYGAPVTVPYSTMIPQQPQNSVQQLNNFVHGPMFNSGGAGGMNINQHIYPGSTHPVGSTYLVAESISLDFKNGDITADANGYNPGFALRLRFRCLSYLLVQYIYTCTVKIDWNFCIFYSHLEYYYILLIIANFKYFRELGLYILPHEILRMPVSQQKEKIGPWSGFALEQANTCNCGFSAVRHRYLSLCSGLFSDDSEEATAIPIKHSVAAVNGIGEGVMQPSSQIWFDASTSTDMNIHTSILPSLGVTGWCFMGYIVFFKNLLFAFYRCTQGSGNIVEGPLTWRSLTTKSLKSATGQEEDSFLPEPIPCINIATEKEAIRAAPQIIRHWEQMSLGPIDQPKDVLYLSVIPDNADIHAMTIKYMDQMSQMYERMRLGRHIFSSLGSGAAAAAIAQAAERSTEGSSQSFLLTQQPIAPQVAPQKGGISALFFNCFRQQFVSLVFFLLFTIRLSPYSICPLSYSEILGSVQCILPSTTALPHTKTRGWESNSNITRRTGMIESLIKNVLKYIFMLYSIYKYRAKTQILDAMGRLWTYIIGVLSMETRNWRLVIGRLGRIGHGEFRAWTHLLNKQALRRHSARLKEVCSACAQMPGGGGTPAILSACLISTEPEPNLRIFPGYSANDSYGLEITYIAYLLRRKVYFNICFMSVVRFLGRESVHYLLLRILVVPILWYSPQELIFRIVIWMDLNRVLDSEQQAVLFSLTMLVEDEYLRGKSSGTDKLEKESPLDSARTDEVLRFLFFNILKIHVD
Length1023
PositionMiddle
OrganismHeterorhabditis bacteriophora (Entomopathogenic nematode)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Strongyloidea> Heterorhabditidae> Heterorhabditis.
Aromaticity0.10
Grand average of hydropathy-0.053
Instability index51.26
Isoelectric point8.68
Molecular weight114088.24
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10579
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     247.58|      66|      78|     123|     198|       1
---------------------------------------------------------------------------
  123-  188 (109.09/50.85)	TPVSGYVRKQIVPSSSRFSAVEDK.VALCSAIAHRRGPVHMPPDYHKPVSNLDKRVPKQLSVELLLS
  202-  264 (106.72/62.14)	TPVTSFSNPGYKPN...FGAISGA.TTTTSSLPSMGAIPPMQHQQITGFPNSQIRTPPMIMGRSITS
  434-  466 (31.77/ 8.79)	.PWSGFALEQANTCNCGFSAVRHRyLSLCSGLFS.................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     452.88|     127|     193|     648|     785|       2
---------------------------------------------------------------------------
  524-  622 (66.40/27.70)	............................................................CF.MGYI..VFFknLLFAF....Y.R.CTQGSGNIVeGpltwrslttkslksatgqeedsflpePIPCINIATekeaiRAAPQI.IRHWEQMS.L...........GPIDQ.PKDVL.YLSVI
  648-  785 (203.71/126.21)	LGRHifsslgsGAAAAAIAQAAERSTEGSSQSFLLTQQPIAPQVAPQK...GGISAlffNCFRQQFVSLVFF..LLFTIRLSPY.SICPLSYSEIL.G..........................SVQCILPST.....TALPHTkTRGWESNSNITRR.......TGMIESLIKNVLKYIFML
  846-  979 (182.77/94.25)	LRRH.......SARLKEVCSACAQMPGGGGTPAILSACLISTEPEPNLrifPGYSA...NDSYGLEITYIAY..LL...RRKVYfNICFMSVVRFL.G........................reSVHYLLLRI.....LVVPIL....WYSPQELIFRiviwmdlNRVLDSEQQAVLFSLTML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     131.53|      39|     260|       5|      59|       3
---------------------------------------------------------------------------
    5-   29 (46.71/17.02)	..............................................................................................................................................................................................................................................YGWPRVGGPP.SAGDPSMN...HIYP..TPP
   30-   44 ( 6.02/17.52)	SVQsEAQQFSPAPVL..............................................................................................................................................................................................................................................................
  268-  290 (34.90/ 9.88)	...............pphstvintnqarhisvylsvvldttlmniasqhqliimnaktepqipeplqemeddeqkplvplgstmdkllnrinntpvsgyvrkqivpsssrfsavedkvalcsaiahrrgpvhmppdyhkpvsnldkrvpkqlsvelllsfpsnipstapsqmtpvtsfsnpgykpnfgaisgattttsslpsmgaippmqhqqitgfpnsqirtppmimgrsitshglYGTPTPYGAP..VTVP.YS...TMIP..QQP
  293-  327 (43.90/19.20)	SVQ.QLNNFVHGPMF.........................................................................................................................................................................................................................................nSGGAGGMNinqHIYPgsTHP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10579 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NFGAISGATTTTSSLPSMGAIPPMQHQQITGFPNSQIRTPPMI
2) WPRVGGPPSAGDPSMNHIYPTPPSVQSEAQQFSPAPVLPPHSTV
215
7
257
50










Molecular Recognition Features






MoRF SequenceStartStop




NANANA