<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10568

Description Uncharacterized protein
SequenceMGMKSLNVISWHYQTPERRALKRNRLGPPDVYPQDAKQEEDNLGADRLKKGYQVAVTSYEHESIVYNVKMPRLDRLDDTMLRGAQLVMQIMAKKMELNANLDKERKRAGSAITKENIGSGGNGVGVGPQIHFQQFSHNAEKAKKSKERNDWFTDLAHGKPLAILARKPPFFRKKEDALEYLCDYKVPVNRALWFLKLIAVGGQGCSSNVNKQKKSTTDQLASELASLFAKFVKLMLNQMSDSAKLESNIVYTDRWPHFVYICKHAYEDGMVEKQEFLMDLLDIFNDRFVQPIENHQNDKSSIHSFLHHGSGLASSGNQSHYITLFRLFLLFICQYTDQITQNIVLSKRCAFLICHRLELYRDEAEEREGRSVDCAELFDDMQQCIHQRAIILTLCGMLHAILIDCPAALIWNKYEVSPGRPPTMLHQLCGSPLDHLPCPFESLPLPPGHGTERLQDFIQLRLAEVRRRSRACENKWSLNYAQKKGFAAMVLQCLEIVGVLDSARLDQSNCIEKIYAVIFNGPSKESFEHEHAIRVKMLLQWAVTMEREGTYRAILVAQLLAFRINHRKTFKFGILFHPIPNAYCLRCLFAEIASRGSLTLQEILLEFLVTEGPDPESTDKNRFCQEFGNLMLLFIELERAGVFSHDFYVKELIRTGEMLEYMPLMQKVRKRKEDKQKVNFFLRFRMSFNCSHGAVTTPSSLVTMPSELPDEHPYIWEDLSIHERLLIHLPIPQSAEYRSECNQRSLLLYGIGNERDAVKLELRRLARELAKLWQKRIVVEFSFNKPLEIRFKKRATREQLQESMAKFRSCTYYDQLVLCGWCCESFIQMVQDFVDGHSCVLPTAEGLDIILEMCEVAQNIAGIMELAEELLPLLVLIERVLLERRVDCVPSNISAQLGYVLTAYISHNYYYFLYSQNAPNIVQGLYRVIESQLKSSDSCLTGWGRTIAVFVLDAKKQLIETGLCSRKIEAKRELLKRVIPPWKPTHNTGDRNPCGGQRYAYNASTFKELLEEPKRIFSFNEYRRLHAVIDGTDDARYSFVVSALLAAVRGAGSVGGNESSGIGCTTAAERVTGDRLVELANICGHVSAQAAQAEKYLDWCGALQALCCSSLQGGTSAFPDLLMEINVEDSTCHYNIATFYMLLAGRSCFSINALVHQLLHTALKSLLNCGIGKVPDADAEAGVCLALLVLANIICQSDQPIILSPQYTGERISSNICKADRWILTESHLHDVGDEVCALLVTICMIADYTKHKLRDRYSDDAKSIDQRAFRREYIAELSKGVLMAMCEQEWVTQRIYRRCEDGATDCFSSHQLRKNCLGQQLLRMALRRRSEREIVRELTICNGNSKKSLIDKLLNVLNIWNTRATYFDFKLMIREISPEGCTSKHAQQGAIAADALLGEIGKCCRDLFTQSHKSDKKLPPAAVGKAFRLKDITAYWLISPLVHACPRPGNLPASFPAITVQGKFLKEAAAMLDTSSDNNKERIQQSAWLLSQEPFLNLVLTCLNGEEQQRDGLVGSMLKQLQELALKAKDNPLLPYLRIFSLEREGVLLRISLVGGMFDSVCHTSICDTWALTLFQLMLYGVISKERDGYLFDSCYDMLSTLLVWSITDPMNAAAMNAQDPDTKFRFPTYSLIVKKLRKELNERALIPELRSLMQFLPIPKPQFELITCEPYGTIPTSPQKLGKSQSQGQIIQTIKANRHGLQFAEKVKLSAYDMIQYLNVDSTLLKRPWNWSMLQAVKLDRLPVPVQRYIQRLVHHSHYNEFVRPTICGMDRPPNLDIYLSPPMMDVSETPATLHHVSSSAATSTTTSASSTNVPVSSGGTAMDVSGTLGPVTQGRAMGGYQSNATPSCTSVPDGSAPSGAPGAPNAATTMIFPGQGGPMPTLPDLTGRGQNSASPRGARGGRRKATGLSTRSQGTTRKQRQQRQQTVDQLAAAAAAAAAAAQQQQQMTGTVSCSSGGPPPQPTYPGTWATGPQQTGVPQQFASGPSVPSTGAGQPGAPMGSQTTEDSKMKIHSMILQKRQAQAASGATAAQQGGTGGPQSAMQDVNAYQISGGPGQYGGGMVMKVETGANSMQMADHAQQQQQQQQQQQYAQQQQLIQMQQDTQGGTQYVIHHQQQRGGVAYGQQSVQQATYDSRFNQQQLSYGQQPHQQQQQQYHPSQQY
Length2164
PositionKinase
OrganismLoa loa (Eye worm) (Filaria loa)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Loa.
Aromaticity0.08
Grand average of hydropathy-0.312
Instability index49.24
Isoelectric point8.46
Molecular weight242260.94
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10568
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     112.65|      19|      19|    1837|    1855|       1
---------------------------------------------------------------------------
 1837- 1855 (33.80/16.60)	GRAMGGYQSNATPSCTSV.P
 1857- 1876 (27.83/12.25)	GSAPSGAPGAPNAATTMIfP
 1877- 1892 (25.30/10.40)	GQ..GG.PMPTLPDLTGR.G
 1969- 1981 (25.72/10.71)	GTWATG......PQQTGV.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.36|      32|     115|    1595|    1629|       2
---------------------------------------------------------------------------
 1593- 1627 (53.66/44.61)	FDSCYDMLSTLLVWS..ITDPMNAAAMNAQDPDtkfR
 1628- 1647 (25.01/11.37)	FPT.Y....SLIVKK..LRKELNERAL..........
 1712- 1743 (45.70/29.26)	..SAYDMIQYLNVDStlLKRPWNWSMLQAVKLD...R
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     241.39|      88|     135|     987|    1107|       3
---------------------------------------------------------------------------
  987- 1107 (113.63/186.10)	NTGDrNPCggqryAYNASTFKELLeEPKRIFSFNEYrrLHAVIDgtddarysfvvSALLAAVR.GAGSV.GGNESSG..........IGCTT.....AAERVTGDRLVelANICghvsaqaaQAEKyldW..............CGALQALC
 1126- 1244 (127.75/103.13)	NVED.STC.....HYNIATFYMLL.AGRSCFSINAL..VHQLLH...........TALKSLLNcGIGKVpDADAEAGvclallvlanIICQSdqpiiLSPQYTGERIS..SNIC........KADR...WilteshlhdvgdevCALLVTIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     103.15|      18|      22|    2036|    2053|       4
---------------------------------------------------------------------------
 1941- 1958 (24.07/ 8.87)	AAAAQQQQQM.....TGTVSC....SS
 2036- 2053 (31.25/13.79)	GGTGGPQSAM.....QDVNAY....QI
 2055- 2077 (23.13/ 8.22)	GGPGQYGGGMvmkveTGANSM....QM
 2078- 2099 (24.70/ 9.30)	ADHAQQQQQQ.....QQQQQYaqqqQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     305.70|      94|     126|     663|     764|       5
---------------------------------------------------------------------------
  606-  661 (24.39/ 6.17)	...................................................................EFLVTEGPDPEST.......DKNRFCQEfGNL.MLLFIELERAGVfshdfyvkelirtgeMLEY..
  663-  764 (150.39/111.70)	PLMQKVRKRKEDKQKVNFFLRFRmsfNCSH.......GAVTtpSSLVTMPSELPDEHPYIwedLSIHERLLIHLPIPQSA.......EYRSECNQ.RSL.LLYGIGNERDAV...............KLELRR
  786-  885 (130.91/77.48)	PLEIRFKKRATREQLQESMAKFR...SCTYydqlvlcGWCC..ESFIQMVQDFVDGHSCV...LPTAEGLDIILEMCEVAqniagimELAEEL.....LpLLVLI..ER..V...............LLE.RR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     278.81|      87|     131|     373|     468|       6
---------------------------------------------------------------------------
  373-  468 (150.72/108.18)	DCAELfdDMQQCIHQ.RAIIL...TLCGMLHAILIDCPAALIWNKYEVSPGRPPTML.HQLCGSPLDHLPC.PFESL..PLPPGHGTERLqdfiqlrLAEVRRR
  501-  595 (128.10/74.87)	DSARL..DQSNCIEKiYAVIFngpSKESFEHEHAIRVKMLLQWAVTMEREGTYRAILvAQLLAFRINHRKTfKFGILfhPIPNAYCLRCL.......FAEIASR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.40|      13|      37|    2103|    2128|       7
---------------------------------------------------------------------------
 2107- 2119 (24.96/10.45)	QGGTQYVIHHQQQ
 2131- 2143 (22.44/18.77)	QQATYDSRFNQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.89|      34|      39|    1397|    1435|       9
---------------------------------------------------------------------------
 1397- 1435 (46.44/33.67)	LLGEIGKCCrdlfTQSHKSDKKLPPAAVGKAFrLKDITA
 1438- 1471 (56.44/27.92)	LISPLVHAC....PRPGNLPASFPAITVQGKF.LKEAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.05|      38|      39|    1482|    1519|      11
---------------------------------------------------------------------------
 1482- 1519 (65.96/34.69)	ERIQQSAWLLSQEPFL.NLVLTCLNGE.EQQRDGLVGSML
 1520- 1559 (53.09/26.66)	KQLQELALKAKDNPLLpYLRIFSLEREgVLLRISLVGGMF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10568 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ETPATLHHVSSSAATSTTTSASSTNVPVSSGGTAMDVSGTLGPVTQGRAMGGYQSNATPSCTSVPDGSAPSGAPGAPNAATTMIFPGQGGPMPTLPDLTGRGQNSASPRGARGGRRKATGLSTRSQGTTRKQRQQRQQTVDQLAAAAAAAAAAAQQQQQMTGTVSCSSGGPPPQPTYPGTWATGPQQTGVPQQFASGPSVPSTGAGQPGAPMGSQTTEDSKMKIHSMILQKRQAQAASGATAAQQGGTGGPQSAMQDVNAYQISGGPGQYGGGMVMKVETGANSMQMADHAQQQQQQQQQQQYAQQQQLIQ
1791
2101










Molecular Recognition Features






MoRF SequenceStartStop




1) IHSMILQKR
2) TYDSRF
2014
2134
2022
2139