<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10567

Description Uncharacterized protein
SequenceMERCSFIVKKKNRQCRMLVKNGQKYCGEHAVCDELNEDRIFCPNDPNHTVNKSQLQKHLSSRCNSRLSKDPWVVENFNLIGSPNELEPWYRPTDDELLRMRRIIERIYDRIADDITDSFLRNEYVENCAANLPKLNKKHIWQISSIIEHLRVVDLLNNDKRKCLIDFGTGRAQLSYWMAKIAPECRFLLIEKMGSRNKFDNKIHKELDLVFVERIRCSVEHLDLSKTDLIRDVDNVAAVCKHFCGAATDSGIRCLMNGVKNGLNVCGFVLAPCCHHRITYAEYVGRIFLESYGICSSNEFAALRHISTWAVCGFPSQSGNLEHKAMVSLNSTEKELLGQKAKAVLEFGRVIELRNCLFERVNNLDLLRSSGLNSVPGPETSEEQKKRFEIECEFVQALANPHYLNFLAQRGYFKEQYFINYLKYLLYWKRPEYARALKYPQCLHFLEAVQSSAFREAITCTANAKFIEEQQLLQWQYYTRKRQRLHMYTTEHDDNEQEWKQQQPQQRQKAPPASS
Length515
PositionMiddle
OrganismLoa loa (Eye worm) (Filaria loa)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Loa.
Aromaticity0.10
Grand average of hydropathy-0.523
Instability index50.77
Isoelectric point8.58
Molecular weight60116.16
Publications









Function






Annotated function

tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro)
and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
metal ion binding	GO:0046872	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro
tRNA 2'-O-methyltransferase activity	GO:0106050	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10567
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.80|      23|      42|     393|     415|       1
---------------------------------------------------------------------------
  393-  415 (42.16/27.24)	EFV..QALANPHYLNFL..AQRGYFKE
  432-  456 (35.33/21.70)	EYA..RALKYPQCLHFLeaVQSSAFRE
  465-  484 (20.31/ 9.52)	KFIeeQQLLQWQYYTRK..RQR.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.86|      11|      42|     103|     114|       3
---------------------------------------------------------------------------
   86-   96 (22.11/ 9.55)	LEPWYRPTDDE
  104-  114 (18.75/ 6.80)	IERIYDRIADD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.42|      22|      33|     237|     259|       4
---------------------------------------------------------------------------
  237-  259 (37.03/21.56)	AAVCKHFCGAATDSGiRCLMN..GV
  271-  294 (37.40/17.86)	APCCHHRITYAEYVG.RIFLEsyGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.06|      14|      19|     180|     193|       6
---------------------------------------------------------------------------
  180-  193 (24.44/17.63)	KIAPECRFLLIEKM
  202-  215 (22.62/15.75)	KIHKELDLVFVERI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10567 with Med31 domain of Kingdom Metazoa
Unable to open file!