<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10560

Description Uncharacterized protein
SequenceMGFHLFDIIKEVRDFVGRGNVEADMIDYQFKEELIKTRERVEDLYSFEGFKVGRGTYGHVYKAQPRHPEEIPGNGAKEFALKLIEGQGFSMSACREIALLRELKHPNLIKLQRVFLTTDRKVWLLFDYAEHDLWHIIKFHRAAKQKKQPVLVPKGMVKSLLYQILDGIHYLHSNWILHRDLKPANILVMGEGPGVERGRVKIGDMGFARIFHNPLKPLAELDPVVVTFWYRAPELLLGAKHYTKAIDIWAIGCIFAELLTSEPVFFCREEDIKASSPYHQDQLNRIFTVMGYPSENDWQDLKKMPEYQKLTQDFKRANYANCTLQRYMDKHKIKADTRSFSLLQRLLTMDPIKRVTAQDAMDDPYFKEDPRPTADVFSGCDIPYPKREFLSDENDDKSASASKPQQVQPPQQSQQQPIGMHPQQSVMEPATKKIRMQQGPQIPATQQIESMMNAPTSGLFATSGAQDYPPVGSGPAISNKGGMSFEQHSQQQIMQSQHINNGMQQISYGHQQQHQVMNQASNMYQQQQIGMNQQIIGPSQGQMAQRSVQMSTQSSVMQSYQQQMVQPGMLSGQQIMGSGNGMLGQQGSITGPGPIGGPQNQMGPPQGQMGPQGPTIMQQIRPQMSYVDQNGRVIQGGGIIMQPGQEMMPQQGPYMIQQQWPQIQPRY
Length667
PositionKinase
OrganismLoa loa (Eye worm) (Filaria loa)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Loa.
Aromaticity0.08
Grand average of hydropathy-0.600
Instability index51.44
Isoelectric point8.51
Molecular weight75664.72
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10560
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     258.08|      35|      35|     497|     531|       1
---------------------------------------------------------------------------
  394-  418 (27.90/ 6.05)	..............NDD..KSAS.AS....K..PQQVQP.....PQQS........QQQ..PI..
  446-  494 (32.61/ 8.21)	QQI...EsmmnaptSGL..FATS..G....A..QDYPPVgsgpaISNKGGMsfeqHSQQ..QI.M
  497-  531 (69.67/25.15)	QHI...N.......NGM..QQIS.YG....H..QQQHQV.....MNQASNM....YQQQ..QIGM
  533-  569 (37.36/10.38)	QQI...I.......GPS..Q.....G....QmaQRSVQM.....STQSSVM..qsYQQQmvQPGM
  573-  617 (42.32/12.64)	QQImgsG.......NGMlgQQGSiTGpgpiG..GPQNQM.....GPPQGQM....GPQG..PTIM
  618-  648 (48.23/15.34)	QQI...R............PQMS.YV.......DQNGRV.....IQGGGII....MQPG..QEMM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.78|      30|      35|     304|     338|       2
---------------------------------------------------------------------------
  304-  338 (50.74/52.59)	MPEYQK.LTQD.FKRanyanCTLQRYMDKHKIKADTR
  340-  371 (46.04/34.17)	FSLLQRlLTMDpIKR.....VTAQDAMDDPYFKEDPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     126.75|      33|      37|     150|     183|       3
---------------------------------------------------------------------------
  124-  145 (19.61/ 7.80)	...............LLFD....YAE......HDLWhiiKFHRAAKQ
  150-  183 (57.15/39.04)	VL.....VPKGMVKSLLYQ....ILD.GIHYlHSNW...ILHRDLKP
  188-  217 (31.80/16.56)	VMgegpgVERGRVK.........IGDmGF.....AR...IFHNPLKP
  218-  242 (18.19/ 6.49)	LA.....ELDPVVVTFWYRapelLLG.AKHY................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10560 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GRVIQGGGIIMQPGQEMMPQQGPYMIQQQWP
2) PGMLSGQQIMGSGNGMLGQQGSITGPGPIGGPQNQMGPPQGQMGPQGPTIMQQIRPQMSYVDQ
3) QQIGMNQQIIGPSQGQMAQRSVQMSTQSSVMQSYQQQM
4) YPKREFLSDENDDKSASASKPQQVQPPQQSQQQPIGMHPQQSVMEPATKKIRMQQGPQIPATQQIESMMNAPTSGLFATSGAQDYPPVGSGPAISNKGGMSFEQHSQQQIMQSQHINNGMQQISYGHQQQHQVMNQASNMY
631
567
527
384
661
629
564
524










Molecular Recognition Features






MoRF SequenceStartStop




NANANA