<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10557

Description Mediator complex subunit rgr-1
SequenceMDDEEYMKPILPTVPEKCGPPVIPLGYLIEFAIQQIFHELTVLSELLPKKLDSDRKISIVQFAHSTRVLFIKLLAVVKWVKSSKKFESCASICYFLDQQSQYFVDTADRLVQLAREELVFARLPIFQVALAVDVLTVGTFPRLPLCIKNRFIPDPPITPREEACVLARLNQVIQYRLSSYGTKLSPRISKTVIRNGMATMTVNGEFEVSLTLLGERPTTKWTLLNIRILVEDYEIGFGTKLVHPLQVNMLHNVLQLRMDKSLEPLEEVYNLLHSFAQTLQLDVLFCQATQVFSGEMCQYAVIERYDRNIGILTLAYWLKRTHSRYTSQYRIKIFIDKENGNSGLRVRHFPVGKGLPYIDDRSGRLSVNRLLSETVGIRCRERLLRIRERLGLLKPPVIVSLTGRAAPTLTYPLLGTQSHADEMLVVSINDFSGNVVAIVRALGPCPELRELEQLIDDRVPLQAITDKMDRLRILLMLERYRKAVAPLPVRIVPENVFCTRLSSLPELPPDRICLQFIKEEMYYLIVSFTPSEQIGVNIDMYLLSNVERKLNMVRLHPSQLLTTLPESSFPSARNDDDLEPPAKRRRWLGDRRLLTSAVATLDDRLAFMRICEELNRRNVKYKPLTVEPTVGGLILHITDFSEAIPAGSDDFFSSVINCCLRLDTRTRVIWPFECTLINTPLVADFYEPIMRIDYESTKTKTTVMEIHGSGGVSSPNTSESVSTHMIDRLIVFAHMFDPVKEFAAAYYNYYNKYCNVVAFTYHKLVLAYGSNRNMLMILSWRTQKAPNNKQYFYLTFGIGPRRRTTADLTNSETLWNPHVLLASRLQERFNKQRSLIGLVQYLIDSVAPLSALHSFTRIRLQSLRAFCQMMCYDAALALGLQVTLSIVNEYRIRLIYGHVYLEFILLGNSRIGLRDCSLGSNCAFRLRQFCSNFLSPELRSTNEEKSPSAFGWIAASSGPGSLPSHQMVRSPASRIVSSPMSHMSLSVPPIDSFGSSLRYSSDYRSKTPILLDHDSLHCMTSADESGNCPLDQYLFALAYLSKLGPALEGYRREHRGSGAHPVIQFRQLIATPESVRLSVLGAAPPNLKHEPFLVNMNIYLDEETMSLKMKLDFDGDDIPADSDIRTAELYFVRFVARLGNEIAVVAFANACRLAAPGAFSAIARIMSVQMNWTEDTPWRPSIQLVMWSQEGSVPRARISPGIVIDQTNISVLILLCLRPARHNPSEKNADASKHLIPLIYNTQTNTVARRSSGADDDASNATTVLSNVSEQYSLTNEPALWPAIYSLAHNFTVQR
Length1295
PositionTail
OrganismLoa loa (Eye worm) (Filaria loa)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Loa.
Aromaticity0.09
Grand average of hydropathy-0.060
Instability index46.07
Isoelectric point8.67
Molecular weight146610.92
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10557
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.16|      16|     269|     712|     727|       3
---------------------------------------------------------------------------
  712-  727 (29.24/15.34)	VSSPNTSESVSTHMID
  976-  991 (30.92/16.60)	VSSPMSHMSLSVPPID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.72|      14|      15|     111|     124|       4
---------------------------------------------------------------------------
  111-  124 (22.89/14.26)	VQLAREELVFARLP
  128-  141 (22.83/14.21)	VALAVDVLTVGTFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.83|      37|     269|     522|     573|       5
---------------------------------------------------------------------------
  372-  412 (55.33/27.44)	SETVGIRCRERLLRIRER.LGL..LKPPVIvsLTgrAAPTLTYP
  531-  570 (56.49/43.97)	SEQIGVNIDMYLLSNVERkLNMvrLHPSQL..LT..TLPESSFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.37|      28|     257|     583|     610|       6
---------------------------------------------------------------------------
  583-  610 (48.40/33.02)	KRRRWLGDRRLLTSAVATLDDRLAFMRI
  831-  858 (46.97/31.81)	KQRSLIGLVQYLIDSVAPLSALHSFTRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     249.06|      74|     391|     743|     830|       7
---------------------------------------------------------------------------
  756-  830 (127.17/90.61)	VVAFTYHKLVLAYGS....NRNMLMILSWR..TQKAPNNKQYFYLTFGIGPRRRTTADLTNSETLWNPHVLLASRlQERFN
 1144- 1223 (121.89/61.33)	VVAFANACRLAAPGAfsaiARIMSVQMNWTedTPWRPSIQLVMWSQEGSVPRARISPGIVIDQTNISVLILLCLR.PARHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.00|      20|     970|     260|     316|       9
---------------------------------------------------------------------------
  280-  314 (22.23/84.97)	QLDVL..FCQatqvfsgEMCqyavierYDRNIGiLTL
  859-  880 (34.77/ 7.09)	RLQSLraFCQ.......MMC.......YDAALA.LGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.98|      27|      97|     947|     973|      12
---------------------------------------------------------------------------
  947-  973 (50.28/35.86)	PSAFGWIAASSGPGSLPS...HQMVRSPAS
 1045- 1074 (43.70/30.06)	PALEGYRREHRGSGAHPViqfRQLIATPES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10557 with Med14 domain of Kingdom Metazoa
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