<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10551

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSTNGGSLEDCHTNVFALTELNGLKWKCLTTPLSQRTWTSLEQDPVLSAYARCLQAGILCAWRRQPPQPTGTLAAMQLPDYRIDVVKELWVFWYSHEEPDCLTEYTSHLACTEDGQGNWSIPGIQYETRTLFFKALHNLIERNMLKNGYIRIGKYFTRPYEVPSSDRIHCSPNYVNGISFNFFVHGENTVCATVSVQRQPTLFRLSRRHLDLGKKQPVILGPWSMRAVLLPEQPRILDSATPILQQQPPTPHCGSFTSSSAPYSSRCREPLSSVVHQVNPVPSSSVDSDTVSSSYDGTGTISKAAVDKLWSEWLQFFCLIVNVERNISSADTVGYIGYTENASPTKSSLPKMVLVDVDGVHMWYPSSLIVVQASDDLLMRQNEKTTNDDDSDFLNSRSNSSSFTARTPPATGGHTRLRSTPSFRKRKKKLSECDGGLSAERHNAMYGTMVNGARSAQRFFEESFIAPANNRRKENTESPSSSGLGLLMSAATSDDDCRWNFTDGMRRKDREEECGCHQCRIQHSSGTATMSNLSSQCIAPQQGMYVCIGQDPSQSCCAPINFSSNGSSLKAKKERPVIFHRRSSFCARSLSPPRSPPWEKKILATSSEVLDGEPNLDWIRESYFPNSRSSSRSGRTDSMHEDRHICPKTPDALGITGNAERRRVQRNSVQMFSKIGSCKPVYQNLSPTSRPRSPACDTSQTESLNRMQSKDCLSNDFASLSARKRGPTIAEQQPNLINSLRLRKDRKSKGRKRKADEKLEWSGIESLDVSFLTAKVGEDNEDGDGINFTCSNDFNLHECKLEINNGAVESSGSSRSAVPQTGSSLNNILTSQAQDGLRNLPVFSQIGSVLPSSASVNLTSSIFTSDCDTQPLFLDDCNPSAIAVIERRSPVDTVVTDSVHLSPPASNERVEPTQILGGTVANVMARVGGPPSVGDYMIYPTPPSVDATQSQQFSPQNTLIQANPTSILYPPTVSYMAAAAAAVNLCHSIPPAQLPPSIISETDITTDIASSVKREFDNDDERLLGKLHYSIDEKPVYGKFMKLEMTLSGKFAGNILAKEFLSLEAKKCRMLEGVYADQLKLIKTAVAAREKRKKVGRAPDYLFMRERLRNLAPHSPFATVRHYRMPYNNGHMLPSHCLPTLQMLPHGMSMNGVSNYVTNGPPFTGTSYNANNSVMSLIMGSGCMPSGGNAIMQPMPVSSRIGVVHMNQQMPMTHLRPLARMPSIPPYASSQMGALQHTPFMGQSAQFCGPPGVMNAPNPICSFPGGPICSMSSGPMQSSHMLGGMHGTTPSQPPQSLGANTIHSTGPPNGQFSIQQPQQPFQQLSHFVNNANFNGQMGMGIVNPSQQNTYQQQMMFRCHMSGNLPAQHPIHSSDSYGIDSQSHASVEPPPSFSQAVNHQYAAVHNVQAGSMMYSQSGHIMRPNTLMAQAQNPNMMCGPRTSQNPMMTVPSSMGSPNNGGIFGSRLMNMPHVMDTTAVPTSNIRTNPEGKSLVLAVLLQDTVLDLHYDSVFDACPICSCNGSIRAKELGVYITPPEVLRQPAAQQQLIVSKPTSGFYNNTSNSCNCGFSAVRHRYLSMKAGLFAEDAKEATDINETQSQPAIPHTIWFDSMSGRDMNFIALLREQTLVRDLGGLLDQVTLLSLQCERASQTERIGSDSSKHCEYIISEVDQRELPLVFQAACEVACMEMNCRRPPHDVRSVLLHDWGVQVSNEMREPRESECMALLQEIGPILEESLRIARSSPLFGSNNIVEGPLTWRFFDRKALKAAGGMEDDSGPEAVPNIVVASEKDAVITSPQIIRLWEKMSLEPYDQPKDVLYIGVVPDNLICIEKTKKYLMDLSRMYEQCRFGRHIPFSREVLRDGLLRVPTRYPATNPGECDNFLNQVERHIGDNKSLITRLKVYMQYFENEMARILINNDDIFSRDKYRAALADNQMHSLPHVSMASYQCGGYTVSSSDHMPPPSAPGSIIISGQSSEASHGPSSTSGPNSSSATSASIGESLTPEGSIGDGSAQNMNSFSSFMTEQLVADGIIAEDEPGTLPHVIVIYLVNPFLLGAEENPLVARVVTVALMRAFNALLYRLNNKRRPQLQLEMIALQSIFDYCGVSADFLKDERGRLNGYDQGRLEKSQNERLSSSDSLKTIAFSVYTHSRVVLPDIVRGILPKSMTRFGPASAMVDLLNELERKEPIYYKVPSKPFILAPPSPVMQRPNCDLMQISTDEAVLFVSYCLIGNDWLAATVTDHQGHSLDNCLINLRLKPDHKRVNMRYKQSTQIRDSLYRLWSYILGTLANGTRNWRLVIGRVGRIGHGEFKFWTQILSKSYLKQVGTRMKHVCRACHVMPGTSEVPGVLSACLVSLEPEAHLRVFPSSFQHDDRFLKNSRHRTLTTPDDTSCTHILVFPTSPELNLDHQGGNGVAELEEDDFSNLLTEEIGEEFSELIGNGEDLMTNGTGPPPQSTSFRLGGNTGIPSEYADLSIENQPLATGYYISTAPASDLPEWFWSACPSAKRRNPVHLKSSLHLNTPNVQQGDDISSFGKGTEACHHQLDSQATADVLRYVLEMYNALSWLNMDLVNGERRSCLPVHIQALMWLCNAVNRFIN
Length2598
PositionMiddle
OrganismLoa loa (Eye worm) (Filaria loa)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Loa.
Aromaticity0.07
Grand average of hydropathy-0.389
Instability index57.73
Isoelectric point6.61
Molecular weight287045.86
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10551
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.29|      31|      33|    1126|    1157|       1
---------------------------------------------------------------------------
 1126- 1154 (51.90/24.60)	......PYNNGH..........MLPSHCLPT.....LQMLPHGMSMNGVS
 1156- 1204 (36.89/16.58)	YVtngpPFTGTSynannsvmslIMGSGCMPSggnaiMQPMPVS.SRIGVV
 1205- 1233 (37.49/12.95)	HMnqqmPMT..H..........LRPLARMPS.....IP..PYASSQMG..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     677.08|     174|     181|     401|     578|       2
---------------------------------------------------------------------------
  401-  553 (254.80/155.90)	...............................S.........SF.TAR..T..PPATGGHTRLRSTPSFRKRKKKLSEC.DG..GL..SAERHNAM..YGTMVNGARSAQ..RFFEESF.IAP........ANNRRKENTESPSSSGLGLLMSAATSD........DDCRWNFTDGMRRKDREEECGCHQCR.IQHSSGTATMSNLSSQCIAPQQ..GMYVC.....IGQDPS
  554-  735 (225.26/143.72)	QSCCAPINFSSNGSSLKA..KKErpvifhrrS.........SF.CARslS..PP........RSPPWEKKILATSSEVlDGepNL..DWIR.ESY..FPNSRSSSRSGRtdSMHEDRH.ICPktpdalgiTGNAERRRVQRNSVQ....MFSKIGSC........KPVYQNLSPTSR..PRSPACDTSQTEsLNRMQSKDCLSNDFASLSARKR..GPTI......AEQQPN
  738-  932 (197.02/119.27)	NSLRLRKDRKSKGRKRKAdeKLE.........wsgiesldvSFlTAK..VgeDNEDGDGINFTCSNDFNLHECKLEIN.NG..AVesSGSSRSAVpqTGSSLNNILTSQ..A..QDGLrNLP........VFS..QIGSVLPSSASVNLTSSIFTSDcdtqplflDDCNPSAIAVIERRSPVDTVVTDSV....HLSPPA.....SNERVEPTQilGGTVAnvmarVGGPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     118.30|      18|      31|    1257|    1275|       3
---------------------------------------------------------------------------
 1257- 1275 (33.67/20.93)	PN.PICSFPGGPIcSMSSGP
 1290- 1307 (25.73/ 9.94)	PSqPPQSLGANTI..HSTGP
 1422- 1438 (32.45/14.69)	PN.TLMAQAQNP..NMMCGP
 1442- 1455 (26.45/10.44)	QN.PMMTVPS....SMGS.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     502.29|     160|     571|     938|    1114|       4
---------------------------------------------------------------------------
  938- 1114 (239.48/179.06)	IYPTPPSVdatqSQQFSPQNTLIQANPTSILYPPTVSYMAAAAAAVNLCH.SIPPAQLPPSIISETDIT.TDIASSVKRE..FDNdderLLGKlhysiDEKpvYGKFMKlEMTLSGKFAGNILAKEFLSLEAKKCRMLEGVYADQLK...LIKTAVAAREKRKKVGRAPDYLFMRERLRNlAPH
 1529- 1695 (262.82/154.83)	VYITPPEV....LRQPAAQQQLIVSKPTSGFYNNTSNSCNCGFSAVRHRYlSMKAGLFAEDAKEATDINeTQSQPAIPHTiwFDS....MSGR.....DMN..FIALLR.EQTLVRDLGGLLDQVTLLSLQCERASQTERIGSDSSKhceYIISEVDQRELPLVFQAACEVACMEMNCRR.PPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.42|      52|     571|    1333|    1416|       5
---------------------------------------------------------------------------
 1350- 1416 (79.95/85.08)	YQQqmMFRCHMSGNLPAQHPIHSSDSYG...IDSQSHASveppPSFSQAvnhqyaavhNVQAGSMMYSQS
 1902- 1956 (90.47/38.11)	YMQ..YFENEMARILINNDDIFSRDKYRaalADNQMHSL....PHVSMA.........SYQCGGYTVSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     369.41|     111|     181|      23|     144|       6
---------------------------------------------------------------------------
   23-  144 (184.86/129.45)	GLKWKCLTTPLSQRTWTSLEQDPVLSAYARCLQagilcawrRQPPQP.TGTLAAMQLPdYRIDVVKEL.WVFWYSHEEPDCLTEyTSHLACTEDGQGNWSIPGIQ..YETRTLFFKALHNlIERNM
  213-  327 (184.55/102.93)	GKKQPVILGPWSMRAVLLPEQPRILDSATPILQ........QQPPTPhCGSFTSSSAP.YSSRCREPLsSVVHQVNPVPSSSVD.SDTVSSSYDGTGTISKAAVDklWSEWLQFFCLIVN.VERNI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10551 with Med13 domain of Kingdom Metazoa
Unable to open file!