Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MGVSNVASQPGSAYQQTVSMLHQSFKNPNWPPNFITPDNVLDYFCDPGNVFYDVSSCNQHIRMQNLNRPLHDCLQSMQGIQYTVVGTFPPLYVIMKQRRNSPTNVTPLAYYYIVNGTVYQCPDIYTYIQSKLISIVDPLRQALEQARNFNRFNIAKGYYWEFKDSNGETIKKAVEEEEKPQLARSTFYQRTRTDQILRELFAKFPPPDDVQFNFGGSEVSAEDDAVAASSIVEKSIRHSSINSQDLTATEDSTSEISQQPAFTSPSSVPLIPAHRSTAESSSGPLSFPGTAPVLGASSTDSQHETDAKRFKGS |
Length | 313 |
Position | Head |
Organism | Loa loa (Eye worm) (Filaria loa) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Loa. |
Aromaticity | 0.10 |
Grand average of hydropathy | -0.519 |
Instability index | 54.50 |
Isoelectric point | 5.55 |
Molecular weight | 34949.46 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP10548 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 156.65| 45| 46| 67| 112| 1 --------------------------------------------------------------------------- 67- 112 (79.55/55.33) NRPLHDCLQSMQGIQYTVVGTFPPLYVIMKQRRN.SPTNVTPlAYYY 115- 160 (77.09/49.25) NGTVYQCPDIYTYIQSKLISIVDPLRQALEQARNfNRFNIAK.GYYW --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) HETDAKRFK 2) LRELF | 303 197 | 311 201 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab