<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10545

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMGDDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDARQVEEYVFNKCVSKDEYMRTIAKVINAINCNSKSAAVPSLLQPSRVQSASQNYRSASLGIPPDPQPTHQQQQQKVMDRYHASPFVQPPPMIQSQQSSPGALSGGCMQPSQSSMQQHSPVIHPVVPQQTPYNMLSPVPSVPGSHSTSPNHQMYSRVKTEPKSSGNDGAEVPISDSMSVRVWKREVPPSGNYYPAGPYGATDSTQYVERTHSSTPFISRATPISSSQQQNASPHHQQQHQPSVLENLINSPHYGSPTPSSRHLNGSGNQNIADLPFGNTIQQNDERIYTEKLRSLRPYIESLRARAQQCRLEGNEIAASKFDTMCNVLDGKSRVSFEYLLQIEAWIYKKQQFLQISLNAGALQPQPLVDAVNAVLLNSETQAGYGDRVQTNTDVPSAGHWSLPSSRSQQQQQQTSPQVLPTMVPSSVSVAHCPGRTTLMQSPVTLQTTSGQQVARHSVEHAYQRHSPYPNPNAGLHTGTQAQSMALHHGLSRQQAATVATTLPPFSESNRAQTTDCSGVEDLYVLDDFLPTPVEAISNSTSSQIEGQLPEAVRQELLAFGDRFLVDPNVEQVADSHSVTIKFSLTSHNVPPLLLIIPKTYPNGEVLVGRAALDLDSFFFDDLQNVIHERLALPGLRTVTDFLETWESTVRGYYLGQQQHSLSPISFDDILQNTNFSDFLS
Length717
PositionTail
OrganismLoa loa (Eye worm) (Filaria loa)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Loa.
Aromaticity0.07
Grand average of hydropathy-0.577
Instability index62.92
Isoelectric point6.08
Molecular weight79151.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10545
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     131.06|      24|     163|     105|     128|       1
---------------------------------------------------------------------------
  105-  128 (47.14/18.49)	PTHQQQ...QQK.VMDRY..H.ASP.F..VQPPP
  150-  176 (25.79/ 7.12)	.SSMQQ...HSP.VIHPVvpQ.QTP.YnmLSPVP
  271-  295 (28.58/ 8.61)	.HHQQQ...HQPsVLENL..I.NSPhY..GSPTP
  484-  508 (29.56/ 9.13)	TTSGQQvarHS..VEHAY..QrHSP.Y....PNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.05|      21|      45|     640|     661|       2
---------------------------------------------------------------------------
  640-  661 (33.67/31.85)	GEVLvGRAALDLDSFFFDD.LQN
  688-  709 (36.39/28.57)	GYYL.GQQQHSLSPISFDDiLQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.71|      23|      33|     563|     585|       3
---------------------------------------------------------------------------
  563-  585 (40.77/26.48)	DDFLPTP.VEAISNSTSSQIEGQL
  598-  621 (35.94/22.44)	DRFLVDPnVEQVADSHSVTIKFSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.54|      13|     290|     178|     194|       5
---------------------------------------------------------------------------
  178-  193 (21.28/18.33)	VPGSHSTSPnhqMYSR
  244-  256 (22.26/ 6.18)	VERTHSSTP...FISR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.69|      32|      44|     304|     336|       7
---------------------------------------------------------------------------
  304-  336 (51.58/40.43)	GNqNIADLPFGN..TIQQNDERIYTEKLRSLRPYI
  350-  383 (49.11/33.30)	GN.EIAASKFDTmcNVLDGKSRVSFEYLLQIEAWI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10545 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVPSLLQPSRVQSASQNYRSASLGIPPDPQPTHQQQQQKVMDRYHASPFVQPPPMIQSQQSSPGALSGGCMQPSQSSMQQHSPVIHPVVPQQTPYNMLSPVPSVPGSHSTSPNHQMYSRVKTEPKSSGNDGAEVPISDSMSVRVWKREVPPSGNYYPAGPYGATDSTQYVERTHSSTPFISRATPISSSQQQNASPHHQQQHQPSVLENLINSPHYGSPTPSSRHLNGSGNQNIADLPFGNT
2) LMQSPVTLQTTSGQQVARHSVEHAYQRHSPYPNPNAGLHTGTQAQSMALHHGLSRQQAATVATTLPPFSESNRAQT
3) MGDDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDA
4) YGDRVQTNTDVPSAGHWSLPSSRSQQQQQQTSPQVLPTMVPSS
75
475
1
421
316
550
39
463










Molecular Recognition Features






MoRF SequenceStartStop




NANANA