<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10538

Description Uncharacterized protein
SequenceMDEPPSKKSRADSEYDSGLDALNALDSLEPLPTSSKDTDVDNPSTSAGGSGGPSGSTPQQQPPTQGTPQPAPASNNGFNLQSGQSGVQPQQQQQAMGGGANGSVLQELLMNPSQASNNSPRPPGYPTGQQPPNAFNRSPMMQNGTNMMSPPPMGGRVPGPSPGGPPQVPGQQQMRPGQQGMFPPGGDQQMMMGTQGQQFPGMMHRYPYGQGPGAQGIAPPGYPGAGRGGPAPGQPMGRGAMMNGTMQRNGPMAAQGRPGMQPGQQQMMQPMMDRQFMQHGQYNQQRPEFMQQYGRGPTAGYPMMHPSQQMMMDSNGQPMRGPNPMMMMSNGHPSMGHAQSGGQPGSQAAAAQHAAQQAAAHAQAQAQAQAQAQAQAQAAAQAQAVAQQQQRDQEAAQRNGAARATTPGSSMLATHQDPEKRKLIQQQLVLLLHAHKCSQREKENRDFAAKNQPQPHAPCTLPHCSTMKDVLTHMTSCNVGRLCPSDTNQTTKKCSVAHCASSRQIIAHWKNCSREDCPVCKPLKRIQDTPLQFSLPDLANLIGVNGNSNGSAEGEAMSQFGSPTLRPGHITNSLFEGFHGDPFRLPNGPNRGGPQRPGGNNGEIPNLPPPDMPDCTKEWHHQVTKDLRNHLVGKLVKAIFPEPDPGAMNDNRLKDLIAYARKVEKEMFESANDREEYYHLLAEKIYKIQKELQEKKNSRLNQGAAVQDPSSAFNNIPPSNELAQMLGVEGRNDVHMEGSSSMAAAPSQQSQPWGGVPSTSMQHQMPNGQVPPSNNGSTFPQSGNSTPNIGASSSTASVLLQPKTEPMDETSESLSSRPTTAIGFGGSSSSTPGPGLNGVIKKEEDPMDEASNQAPESGKDGKDDKSREMQMKRDPTPPPTEDTVFTQEDLIKFLLPVWETLDKSEDAAPFRVPVDAKLLNIPDYHDIIKRPMDLETIYKKLHSGQYQNAGQFSDDIWLMLDNAWLYNRKNSKVYKFGIKLSELFVAEMDPVMKVMGYCCAKKLAFTPLSLFCYGAAMCTIAREQQYWVYEQSSTQFNVTVTERYTYCQKCFDALPPEGISLSENPNDRSNMAPKTAFIEQKNSVIDYEPFERCKYCMRKWHRICALHDKRVYPEGFICDCCRMAKKYQKPENRYLASKLPHNKLSTFLEDRVNSFIKRQLQAEAYKYPVIIRTLCVQDKEAEVKPQMKQKYVDSNQFPEKFPYRTKAVFAFEIIDGVEVCFFGLHVQEYGSECPAPNARRVYIAYLDSVHFFQPRELRTDVYHEILLGYLDYAKKLGYTMAHIWACPPSEGDDYIFHCHPPEQKIPKPKRLQDWYKKMLEKGVQEGSVIEFKDIFKQARDDNLTSPTQLPYFEGDFWPNVIEDCIREASNEEAQRKVKEDDDEGEDGEGGLGGNDSGKKKSSKNKKNNLKKNSKMNKKKAGSITGNEVADKLYSQFEKHKEVFFTIRLVSLSMEPAVLSTPINDPDSLMPSDMMDGRDTFLTKAREEHWEFSSLRRAKYSTLCLAYSLHETDSKGMEYSCNKCNSAALWHCTSCDDFDLCDNCKPLIQHPHELEKLKSLISDGPADSGAGGTRYESIQRCIASLVHACQCRDANCRRMSCHKMKRVVQHTKMCKKRINGTCPVCKQLIALCCYHAKHCTRDTCSVPFCMNIRQKLAEQKRSQQRRADMMMRRRMEGLQSHVGGGAGAPPAPNTTSNGAPSNAPTPPVSAGPGPAAKGGGVGQMQMQQQAGHMGSSGPLSAGIGQSMGSFGGLSGMSGASSSQNGPMSGMNQPMGSNQNRFMPNGQGFGQPGGPGGPGGPNGPNGPGQQNMYTGMQRPGMNHGGLGGMNPGQPQQPGQPGQPGQPPQQQQPGRPGMPGGMAPGPQYSFRNQEMYNMMNMQQGQQGQMQIDNTLQPQITKINARLKAAKTNQERELVFSDLKKTPHLFHAWLRVHGNGQYSNMIPQGLAPQLQNPQQQQHQQFQQQQQQQMQQQAGGMRGANFATAPNGNQPRGPGGQFASMNPSMPQHAQQQQQQGWPGQRQPNPGGMPPNAMQFPNRQQQMMMMQNSHQPSNAGGQ
Length2056
PositionTail
OrganismCaenorhabditis tropicalis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.06
Grand average of hydropathy-0.833
Instability index51.16
Isoelectric point8.60
Molecular weight225775.06
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-KW

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10538
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     219.55|      34|      34|    1794|    1827|       1
---------------------------------------------------------------------------
   98-  154 (36.03/ 7.03)	GGangsvlqellmnpsqasnnspRPPGY.PTGQ...QPPN.A..FNRSPMMQN.GtnmMSPPPMG
 1791- 1825 (63.34/19.02)	GG....................pGGPGG.PNGP...NGPG.Q..QNMYTGMQRPG...MNHGGLG
 1826- 1853 (48.03/12.30)	GM......................NPG..........QPQ.QpgQPGQPGQP.PQ...QQQPGRP
 1945- 1973 (36.59/ 7.28)	GL.....................A.....PQLQ...NPQQ.Q..QHQQFQQQ.QQ...QQMQQQA
 2018- 2054 (35.55/ 6.82)	GQ...................rqPNPGGmP..PnamQFPNrQ..QQMMMMQN..S...HQPSNAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     280.08|      33|      33|     169|     201|       2
---------------------------------------------------------------------------
  167-  194 (50.66/15.70)	...Q....V.PGQQ..QMRPGQQGMFP..P...GGDQQMMM....GT
  195-  214 (35.07/ 7.93)	QGQQFP..G.M..M..HRYPYGQG.....P...............GA
  215-  245 (38.91/ 9.85)	QGIAPP..GyPGAG..R...G..GPAPgqP...MGRGAMMN....GT
  246-  281 (42.10/11.44)	MQRNGPmaA.QGRP..GMQPGQQQMMQ..P...MMDRQFMQ...hGQ
  282-  314 (41.56/11.17)	YNQQRP....EFMQ..QYGRGPTAGYP.mM...HPSQQMMM....DS
 1696- 1731 (32.71/ 6.76)	NG......A.PSNA..PTPPVSAGPGP..AakgGGVGQMQMqqqaGH
 1986- 2015 (39.09/ 9.94)	NGNQPR..G.PGGQfaSMNP....SMP..Q...HAQQQQQQ....G.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     219.27|      43|      46|     771|     813|       3
---------------------------------------------------------------------------
  717-  760 (48.93/17.70)	......PPSNeLAQMLGVEGRNDVHMEGSSSMAAAPSQ.QSQPwggVPSTS
  769-  811 (74.14/30.49)	QV....PPSN.NGSTFPQSGNSTPNIGASSSTASVLLQPKTEP...MDETS
  812-  851 (50.93/18.71)	ESlssrPTTA.IG..FGGSSSSTPGPGL...NGVI..KKEEDP...MDEAS
  852-  880 (45.26/15.84)	N.............QAPESGKDGKD......DKSREMQMKRDP...TPPPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.07|      17|      17|     357|     373|       4
---------------------------------------------------------------------------
  357-  373 (29.91/14.30)	QAAAHAQAQAQAQAQAQ
  377-  389 (21.51/ 7.77)	QAA....AQAQAVAQQQ
  393-  409 (21.65/ 7.88)	QEAAQRNGAARATTPGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     263.27|      46|      47|    1571|    1616|       5
---------------------------------------------------------------------------
  431-  477 (27.59/10.54)	.............LL..HAH.KCSQREkenrdfaaknqpqphapCTLPHCSTMKDVLTHMTSC.................
  494-  515 (24.51/ 8.55)	............................................CSVAHCASSRQIIAHWKNCSR..............E
 1515- 1570 (57.86/30.15)	GMEY.SCNKCNSAAL..WHCtSCDDFD.................L....CDNCKPLIQHPHELEKlkslisdgpadsgaG
 1571- 1616 (81.27/45.30)	GTRYESIQRCIASLV..HAC.QCRDAN.................CRRMSCHKMKRVVQHTKMCKK..............R
 1619- 1664 (72.05/39.33)	GT.CPVCKQLIA.LCcyHAK.HCTRDT.................CSVPFCMNIRQKLAEQKRSQQ..............R
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.31|      31|      48|     997|    1043|       6
---------------------------------------------------------------------------
  964- 1010 (43.68/54.52)	WLYNRKNSkvyKFGIKLSElfvaemdpvmkvmGYC.CAKKL.AFTP..LSL
 1027- 1061 (45.63/20.24)	WVYEQSST...QFNVTVTE.............RYTyCQKCFdALPPegISL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.30|      38|      39|    1305|    1342|       7
---------------------------------------------------------------------------
 1253- 1293 (23.44/ 9.71)	...QPRELR...tDVYHEIL.........LGYLDYAKKlgytmahiwacppsEGDD
 1304- 1341 (64.15/39.58)	KIPKPKRLQ....DWYKKMLEKGVQEGSVIEFKDIFKQ..............ARDD
 1342- 1383 (56.72/34.14)	NLTSPTQLPyfegDFWPNVIEDCIREASNEEAQRKVKE..............DDDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.91|      35|      39|     545|     579|       8
---------------------------------------------------------------------------
  545-  579 (62.53/26.48)	NGNSNGSAEGEAMSQFGSPTLRPGHITNSLFEGFH
  587-  621 (71.38/31.38)	NGPNRGGPQRPGGNNGEIPNLPPPDMPDCTKEWHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.23|      34|      38|    1094|    1130|       9
---------------------------------------------------------------------------
 1094- 1130 (59.55/48.88)	KYCMRKW.H.RICALHDKRVYpeGFICDCCRmAKKYQKP
 1133- 1168 (47.68/27.79)	RYLASKLpHnKLSTFLEDRVN..SFIKRQLQ.AEAYKYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.20|      28|      49|    1437|    1467|      11
---------------------------------------------------------------------------
 1437- 1467 (38.97/41.04)	EKHKEvFFTIRLVSLSmePAVLSTPINDPDS
 1486- 1513 (50.23/37.96)	EEHWE.FSSLRRAKYS..TLCLAYSLHETDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     132.73|      29|      34|      29|      61|      12
---------------------------------------------------------------------------
   32-   61 (48.68/26.39)	PTSsKDTDVDNPSTSAGG...S...GGPSGSTPQQQ
   63-   92 (49.45/16.85)	PT..QGTPQPAPA.SNNGfnlQ...SGQSGVQPQQQ
 1765- 1790 (34.60/ 8.13)	PMS..GMNQ..PMGSNQN...RfmpNGQGFGQP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.39|      13|      23|     662|     674|      13
---------------------------------------------------------------------------
  662-  674 (22.62/13.58)	KVEKEMFESANDR
  687-  699 (21.77/12.80)	KIQKELQEKKNSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.43|      15|      31|    1389|    1403|      14
---------------------------------------------------------------------------
 1389- 1403 (25.93/16.43)	GGLGGNDSGKKKSSK
 1421- 1435 (25.50/16.00)	GSITGNEVADKLYSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      87.07|      15|      34|     889|     903|      16
---------------------------------------------------------------------------
  889-  903 (26.14/17.10)	DLIKFLLPVWETLDK
  906-  920 (21.68/12.73)	DAAPFRVPVDAKLLN
  926-  939 (21.06/12.12)	DIIKRPMDL.ETIYK
  948-  961 (18.18/ 9.30)	NAGQFSDDIWLMLD.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.37|      13|      33|    1206|    1222|      19
---------------------------------------------------------------------------
 1206- 1222 (14.46/26.82)	KAVF.AFeiIDGVEvcFF
 1239- 1252 (20.91/14.76)	RRVYiAY..LDSVH..FF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10538 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASNEEAQRKVKEDDDEGEDGEGGLGGNDSGKKKSSKNKKNNLKKNSKMNKKKAG
2) EGFHGDPFRLPNGPNRGGPQRPGGNNGEIPNLPPPDMPDCTKEWHHQV
3) KLAEQKRSQQRRADMMMRRRMEGLQSHVGGGAGAPPAPNTTSNGAPSNAPTPPVSAGPGPAAKGGGVGQMQMQQQAGHMGSSGPLSAGIGQSMGSFGGLSGMSGASSSQNGPMSGMNQPMGSNQNRFMPNGQGFGQPGGPGGPGGPNGPNGPGQQNMYTGMQRPGMNHGGLGGMNPGQPQQPGQPGQPGQPPQQQQPGRPGMPGGMAPGPQYSFRNQEMYNMMNMQQGQQGQMQIDNTLQPQITKINARLKAAKTNQERELVFSDLKKTPHLFHAWLRVHGNGQYSNMIPQGLAPQLQNPQQQQHQQFQQQQQQQMQQQAGGMRGANFATAPNGNQPRGPGGQFASMNPSMPQHAQQQQQQGWPGQRQPNPGGMPPNAMQFPNRQQQMMMMQNSHQPSNAGGQ
4) MDEPPSKKSRADSEYDSGLDALNALDSLEPLPTSSKDTDVDNPSTSAGGSGGPSGSTPQQQPPTQGTPQPAPASNNGFNLQSGQSGVQPQQQQQAMGGGANGSVLQELLMNPSQASNNSPRPPGYPTGQQPPNAFNRSPMMQNGTNMMSPPPMGGRVPGPSPGGPPQVPGQQQMRPGQQGMFPPGGDQQMMMGTQGQQFPGMMHRYPYGQGPGAQGIAPPGYPGAGRGGPAPGQPMGRGAMMNGTMQRNGPMAAQGRPGMQPGQQQMMQPMMDRQFMQHGQYNQQRPEFMQQYGRGPTAGYPMMHPSQQMMMDSNGQPMRGPNPMMMMSNGHPSMGHAQSGGQPGSQAAAAQHAAQQAAAHAQAQAQAQAQAQAQAQAAAQAQAVAQQQQRDQEAAQRNGAARATTPGSSMLATHQDPEKRKLIQ
5) QKELQEKKNSRLNQGAAVQDPSSAFNNIPPSNELAQMLGVEGRNDVHMEGSSSMAAAPSQQSQPWGGVPSTSMQHQMPNGQVPPSNNGSTFPQSGNSTPNIGASSSTASVLLQPKTEPMDETSESLSSRPTTAIGFGGSSSSTPGPGLNGVIKKEEDPMDEASNQAPESGKDGKDDKSREMQMKRDPTPPPTEDTVF
1368
576
1654
1
689
1421
623
2056
425
885










Molecular Recognition Features






MoRF SequenceStartStop




1) DEPPSKKSRADSEYDSGLDALNALDSLE
2
29