<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10532

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMQIEEKEPENVTEERQKTPDAEPPAPPQTTRVLLASSSDEEPTTGGYDGADEPKPEDIPVKLRWMYEHDFRQEKPKDETPEEKERREHAREVRRKRRKNREERLKEIERQRAEVTNPEEYDSDVVTDPEVEDKEKLVDNEIPKMVLIEIDNVRMLYPSKLICVTLDDDRQMLEAVGLKTAPIPAELQFPIPQNTRRSRVRNVVSLSNPTLQLNTVLQYCQTELRKRKETLKTFGNKGRNIALHQKPSETFLTWGTRDKKFSGIGLDMEDDQNIFLTKMEDPMIKEDGKGKEENENENDDDDEDEEGNEEEEEAEQEELLTFREIALTGRELLVERKDDFHAYHKKRMPKPLKERQKKSNQKSPKGLKQVYNIHGPNYGSARRRKNSFTKGNESFLSTKEVIKDKNDPPNATVRPDSDDEAHQIDKLSQQDWANFDEELIKEIPEIEIIEKEEIFNDVRLTKPPHDENYEPEPFLPITFLTNNVVNNDFEQLSGDEDMSEERFNEVFKDKYNKWKPQFHRGEKIECSNYLFDPSNPPISSPREYHLKEPPKKTKYESVIPTPIGNKYFKGSIVKNGLRGFEEMCIVKDDDETIRKERWLKRARRKFCKQEIKIARNCYLDLQKQFVKRSLKRALTRIRLTAEKDSIVEKPKREKPVSPLLKNKEDKSFEKSLVLMEKELDKLDMNSFCSQHEKAGPFGVPLPSGLIEPDYETSPHGSIDEESESEIDEQRTGLGEGTSDQYQEGDSVDMIQEDEEQFNDPSMEVPSISHIRTVGDHIGPDGMLSPPASNEMPKGGPLSVGPPSIEAQGLNQIYPTPPSVQMLQGDSAQAHSPGTHGKSRTLPIVSEEDSERITISGDIGSVVDVEVTDIETNNMQIWNKTTNQPKLSKFLLSSRNNPILSGRKMKYDTPMTGTFEIAMNLKKPVSGLAYEPMVTRNFEYAPHTSFAELIRVKSCDRRIPAPLSLPQMPSVNPGLMTPTHQLFQSPVLPPQHTPSPFSAGPLGHHPMVPPGYPGTPGTFPPTTPTYSGMTPRPGSTFGPGHVYPHPHHMGAPGYPGQMGPIGPMGVPPMGPMSVQRQFSNPQMLQHHQMQMRMQQMQQMRQMAAQGVPPGYGAPGMPSYPQGAATPGPMGLGMQSGPSSVQRLNNFVNQSQFGPSSVQSMQYGANPSMIPQSPNFNQPYGGMVNPMMSPMQQHQFHQQQMLQQQQHHQHQMQMQMQRTQLQLQHTQSQQAIQTLQPNPLQLLAQQNEQVANAHKNLSERDKLKFTKRQKQLKDGLMPTSLQPTAIKNLRNPPDANVPYKRHEIFNRSPDHNVPRGDSLTVAIVLSDTLLDLHFDSVFDACPICSCSVSIRSRDLGMYINPHTVLSSREGGYTNMREYTLGTWSGFHVNGPTTCTCGFSAIRHRYLSWCSGLFEEDADEATTSDKAVAPVIPPLDYPKKSSARDMIWFDSRSVHDIALIDQIRQMSFSNSLGKAVSQMATAKEHAKNLSITTEVTYDITIPSEYIMSHVDNLELLMLGNSALGPMQKSGTGNLTQVSNDKYLNYFHPWGFQTANEIVELDSSEWADLLGVVTPTLEVSMKQARHIPPETEFIIDGPLTWRQIVAKAYSGKPASEDEEDVSLAEPVPAVMRATEKEAIRAAPNIEQYYEQASLGPIDQPKDIMYLTIIPDDDDIYERTVDFMDAVTDTYETMRLGHHIPFPVSTGTATRFRNVYKSFQQQYPYTEHQQVLNYTNSQLRSMPQKVAGEPDPLDTNPANWTSRAKRKLEIYEDLRKSESEDGDYNPLAVADVTVPSDNVGKRNINSILPPVTSDKHSGGYYEREGILRVGKPLEPNRSQQTVVNTLEFENMTRHLSDANGFVSRLRLYLQQMEDLAHHALIGNPEAFERSGYRYQLAVEERLKREKECKFIEEERLRYEAARREDEQRVPEKPEEADLCCGVELGESTSVKWINDELEEKKRQRQKENEQYPPEGHQAPSPVPAGMIHIPETLSEQEKKVQPTLADIFIDPSIVAPLNAQNIAWKQRDTRVPNPFPSSNQPPIPFEAIGNADTDDFATLPHAIVIYVVNPFSYGTDGQSALHMRVALLSFIRAFNSIVGRLQYLKRPQVQLEIIGLESMDDSASPFPDYFNNPKVPFDILHERPVRNERVEEVGRTEITRSLCVAVYTHPRVFFPDIYKSMSARCMTAFGPGTQLINTINDIEKLNNDSYFRQAKRSKTDLDRMDAYRHPRLMPSHTVEKKNFIAYRVPSNILCLAPPPPVYQMDESGKPIVTPTDEQTLFISYCLVGKEYLVATATDAQGKLIDNCISNIKPRRKNNQVYRYSGKTQILDGMGKLWSFILGVMSSDIKNWRLVVGRLGRIGHGEFRAWTHLLNKSSLLKYSSSLKDICGACRSMPSFTGTPSILSACLITLEPEPSIRVVPEFYDLETMAKKSYIFHTPGDISCTHILTFPVGTEINLEMQDQTADTKAEENWEFGDLDIMEGLDDGDTEIMKDLGLETPSSAAIRQSGTTSFFSEDSSSIEIQNQPLASGYYISTAPAPELPSWFWATCPSAKRHSPVHLKSSLHINISEVKNDDIAMESTKEKDKEKEKEEKDIHPLESRQTEEVLRHVLESYNALSWLNLNRETGDRYSCLPIHIQHLLRLYHNVARLLA
Length2648
PositionMiddle
OrganismCaenorhabditis tropicalis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.07
Grand average of hydropathy-0.727
Instability index54.51
Isoelectric point5.51
Molecular weight300379.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10532
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     100.42|      15|      15|    1134|    1148|       1
---------------------------------------------------------------------------
 1036- 1054 (27.25/11.85)	GPGHVyphpHHMGAPGYPG
 1057- 1066 (21.62/ 7.71)	GP..I....GPM..GV.PP
 1134- 1148 (23.84/ 9.34)	GPSSV....QRLNNFVNQS
 1151- 1165 (27.71/12.18)	GPSSV....QSMQYGANPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      60.35|      15|      15|    1192|    1206|       2
---------------------------------------------------------------------------
 1192- 1204 (21.64/11.62)	..........QFHQQQMLQQQQH
 1205- 1222 (22.14/12.10)	HQ.....hqmQMQMQRTQLQLQH
 1223- 1245 (16.56/ 6.77)	TQsqqaiqtlQPNPLQLLAQQNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.70|      10|      15|     285|     294|       3
---------------------------------------------------------------------------
  285-  294 (18.49/ 8.98)	EDGKGKEENE
  302-  311 (18.21/ 8.73)	EDEEGNEEEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.01|      25|      71|     735|     759|       4
---------------------------------------------------------------------------
  735-  759 (43.58/23.08)	GTSDQYQEGDSVDMIQEDEEQFNDP
  777-  795 (27.23/11.21)	GPDGMLSPPASNEMPKGGP......
  807-  831 (45.20/24.25)	GLNQIYPTPPSVQMLQGDSAQAHSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.95|      16|      19|     975|     992|       5
---------------------------------------------------------------------------
  975-  990 (31.61/11.50)	TPTHQLFQSPVLPPQH
  995- 1010 (30.34/14.52)	FSAGPLGHHPMVPPGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.93|      17|    1937|     639|     658|       6
---------------------------------------------------------------------------
  639-  657 (25.95/25.42)	TAEKDSivEKPKREKPVSP
 2577- 2593 (30.98/16.46)	TKEKDK..EKEKEEKDIHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     209.60|      56|    1937|      63|     118|       7
---------------------------------------------------------------------------
   63-  118 (96.72/63.34)	RWMYEHDFRQEKPK.DETPEEKERREHAREVRRKRRKNREERLKEIERQR...AEVTNPE
 1878- 1908 (29.50/13.08)	..................PEAFERSGYRYQLAVEERLKREKECKFIEEE...........
 1909- 1968 (83.37/53.36)	RLRYEAARREDEQRvPEKPEEADLCCGVELGESTSVKWINDELEEKKRQRqkeNEQYPPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.46|      11|    1937|     181|     191|       8
---------------------------------------------------------------------------
  181-  191 (23.00/10.88)	PIPAELQFPIP
 2028- 2038 (24.46/12.14)	PFPSSNQPPIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     302.51|      97|     770|    1493|    1605|       9
---------------------------------------------------------------------------
 1493- 1604 (139.05/127.26)	YDITIPSEYIMSHVDNlELLMLGNSALGPMQKSGTGNLTQVSNDKYLNYFhPwgfqTANEIVEldssEWADLLGVVTPTLEvSMKQARHIP.PetefIIDGPLTWRQIVAKAY
 1616- 1713 (163.46/99.25)	VSLAEPVPAVMRATEK.EAIRAAPNIEQYYEQASLGPIDQPKDIMYLTII.P....DDDDIYE....RTVDFMDAVTDTYE.TMRLGHHIPfP....VSTGTATRFRNVYKSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.42|      12|    1937|     333|     348|      10
---------------------------------------------------------------------------
  333-  348 (15.85/24.35)	VERKdDFHAYhkkRMP
 2232- 2243 (23.57/14.87)	VEKK.NFIAY...RVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     125.73|      21|      94|    1011|    1031|      11
---------------------------------------------------------------------------
  908-  940 (22.63/ 6.58)	PMT.GTFeiamnlkkPVSGLAYEPM.................VTRnfeyaP
  958-  994 (26.42/ 9.04)	P.APLSL........PQMPSVNPGLmtpthqlfqspvlppqhTPS.....P
 1011- 1031 (44.94/21.06)	PGTPGTF........PPTTPTYSGM.................TPR.....P
 1112- 1126 (31.73/12.49)	PGMP.SY........PQ.....GAA.................TPG.....P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.04|      13|    1937|     358|     374|      12
---------------------------------------------------------------------------
  358-  370 (21.98/18.39)	SNQKSPKGLKQVY
  375-  387 (23.06/ 7.25)	PNYGSARRRKNSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.47|      12|    1937|     515|     534|      13
---------------------------------------------------------------------------
  500-  515 (14.28/17.15)	ERFNEVFkDKYNkwkP
  524-  535 (25.18/ 6.84)	ECSNYLF.DPSN...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.91|      30|    1940|      22|      59|      20
---------------------------------------------------------------------------
   29-   59 (49.67/39.03)	TTRVLLASSS....DEEPTTGGYDGADEPKPEdIP
 2505- 2538 (49.24/19.79)	TTSFFSEDSSsieiQNQPLASGYYISTAPAPE.LP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10532 with Med13 domain of Kingdom Metazoa
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