<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10531

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMQIEEKEPENVTEERQKTPDAEPPAPPQTTRVLLASSSDEEPTTGGYDGADEPKPEDIPVKLRWMYEHDFRQEKPKDETPEEKERREHAREVRRKRRKNREERLKEIERQRAEVTNPEEYDSDVVTDPEVEDKEKLVDNEIPKMVLIEIDNVRMLYPSKLICVTLDDDRQMLEAVGLKTAPIPAELQFPIPQNTRRSRVRNVVSLSNPTLQLNTVLQYCQTELRKRKETLKTFGNKGRNIALHQKPSETFLTWGTRDKKFSGIGLDMEDDQNIFLTKMEDPMIKEDGKGKEENENENDDDDEDEEGNEEEEEAEQEELLTFREIALTGRELLVERKDDFHAYHKKRMPKPLKERQKKSNQKSPKGLKQGYGLLPARPWYSKRDIISRIRTKSPRFVVPREKRVKLYNIHGPNYGSARRRKNSFTKGNESFLSTKEVIKDKNDPPNATVRPDSDDEAHQIDKLSQQDWANFDEELIKEIPEIEIIEKEEIFNDVRLTKPPHDENYEPEPFLPITFLTNNVVNNDFEQLSGDEDMSEERFNEVFKDKYNKWKPQFHRGEKIECSNYLFDPSNPPISSPREYHLKEPPKKTKYESVIPTPIGNKYFKGSIVKNGLRGFEEMCIVKDDDETIRKERWLKRARRKFCKQEIKIARNCYLDLQKQFVKRSLKRALTRIRLTAEKDSIVEKPKREKPVSPLLKNKEDKSFEKSLVLMEKELDKLDMNSFCSQHEKAGPFGVPLPSGLIEPDYETSPHGSIDEESESEIDEQRTGLGEGTSDQYQEGDSVDMIQEDEEQFNDPSMEVPSISHIRTVGDHIGPDGMLSPPASNEMPKGGPLSVGPPSIEAQGLNQIYPTPPSVQMLQGDSAQAHSPGTHGKSRTLPIVSEEDSERITISGDIGSVVDVEVTDIETNNMQIWNKTTNQPKLSKFLLSSRNNPILSGRKMKYDTPMTGTFEIAMNLKKPVSGLAYEPMVTRNFEYAPHTSFAELIRVKSCDRRIPAPLSLPQMPSVNPGLMTPTHQLFQSPVLPPQHTPSPFSAGPLGHHPMVPPGYPGTPGTFPPTTPTYSGMTPRPGSTFGPGHVYPHPHHMGAPGYPGQMGPIGPMGVPPMGPMSVQRQFSNPQMLQHHQMQMRMQQMQQMRQMAAQGVPPGYGAPGMPSYPQGAATPGPMGLGMQSGPSSVQRLNNFVNQSQFGPSSVQSMQYGANPSMIPQSPNFNQPYGGMVNPMMSPMQQHQFHQQQMLQQQQHHQHQMQMQMQRTQLQLQHTQSQQAIQTLQPNPLQLLAQQNEQVANAHKNLSERDKLKFTKRQKQLKDGLMPTSLQPTAIKNLRNPPDANVPYKRHEIFNRSPDHNVPRGDSLTVAIVLSDTLLDLHFDSVFDACPICSCSVSIRSRDLGMYINPHTVLSSREGGYTNMREYTLGTWSGFHVNGPTTCTCGFSAIRHRYLSWCSGLFEEDADEATTSDKAVAPVIPPLDYPKKSSARDMIWFDSRSVHDIALIDQIRQMSFSNSLGKAVSQMATAKEHAKNLSITTEVTYDITIPSEYIMSHVDNLELLMLGNSALGPMQKSGTGNLTQVSNDKYLNYFHPWGFQTANEIVELDSSEWADLLGVVTPTLEVSMKQARHIPPETEFIIDGPLTWRQIVAKAYSGKPASEDEEDVSLAEPVPAVMRATEKEAIRAAPNIEQYYEQASLGPIDQPKDIMYLTIIPDDDDIYERTVDFMDAVTDTYETMRLGHHIPFPVSTGTATRFRNVYKSFQQQYPYTEHQQVLNYTNSQLRSMPQKVAGEPDPLDTNPANWTSRAKRKLEIYEDLRKSESEDGDYNPLAVADVTVPSDNVGKRNINSILPPVTSDKHSGGYYEREGILRVGKPLEPNRSQQTVVNTLEFENMTRHLSDANGFVSRLRLYLQQMEDLAHHALIGNPEAFERSGYRYQLAVEERLKREKECKFIEEERLRYEAARREDEQRVPEKPEEADLCCGVELGESTSVKWINDELEEKKRQRQKENEQYPPEGHQAPSPVPAGMIHIPETLSEQEKKVQPTLADIFIDPSIVAPLNAQNIAWKQRDTRVPNPFPSSNQPPIPFEAIGNADTDDFATLPHAIVIYVVNPFSYGTDGQSALHMRVALLSFIRAFNSIVGRLQYLKRPQVQLEIIGLESMDDSASPFPDYFNNPKVPFDILHERPVRNERVEEVGRTEITRSLCVAVYTHPRVFFPDIYKSMSARCMTAFGPGTQLINTINDIEKLNNDSYFRQAKRSKTDLDRMDAYRHPRLMPSHTVEKKNFIAYRVPSNILCLAPPPPVYQMDESGKPIVTPTDEQTLFISYCLVGKEYLVATATDAQGKLIDNCISNIKPRRKNNQVYRYSGKTQILDGMGKLWSFILGVMSSDIKNWRLVVGRLGRIGHGEFRAWTHLLNKSSLLKYSSSLKDICGACRSMPSFTGTPSILSACLITLEPEPSIRVVPEFYDLETMAKKSYIFHTPGDISCTHILTFPVGTEINLEMQDQTADTKAEENWEFGDLDIMEGLDDGDTEIMKDLGLETPSSAAIRQSGTTSFFSEDSSSIEIQNQPLASGYYISTAPAPELPSWFWATCPSAKRHSPVHLKSSLHINISEVKNDDIAMESTKEKDKEKEKEEKDIHPLESRQTEEVLRHVLESYNALSWLNLNRETGDRYSCLPIHIQHLLRLYHNVARLLA
Length2684
PositionMiddle
OrganismCaenorhabditis tropicalis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.07
Grand average of hydropathy-0.728
Instability index54.56
Isoelectric point5.63
Molecular weight304702.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10531
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     140.41|      15|      15|    1170|    1184|       1
---------------------------------------------------------------------------
 1042- 1055 (23.85/ 8.57)	VPPGYPGTP...GTFPP
 1072- 1087 (20.98/ 6.53)	GPGHVYPHPHhmGA.PG
 1093- 1103 (23.18/ 8.09)	GP..IGPM....GVPPM
 1146- 1160 (22.59/ 7.67)	GAPGMPSYPQ..GAATP
 1170- 1184 (22.39/ 7.53)	GPSSVQRLNN..FVNQS
 1187- 1201 (27.43/11.12)	GPSSVQSMQY..GANPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      60.35|      15|      15|    1228|    1242|       2
---------------------------------------------------------------------------
 1228- 1240 (21.64/11.70)	..........QFHQQQMLQQQQH
 1241- 1258 (22.14/12.18)	HQ.....hqmQMQMQRTQLQLQH
 1259- 1281 (16.56/ 6.81)	TQsqqaiqtlQPNPLQLLAQQNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.70|      10|      15|     285|     294|       3
---------------------------------------------------------------------------
  285-  294 (18.49/11.14)	EDGKGKEENE
  302-  311 (18.21/10.84)	EDEEGNEEEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.74|      24|      78|     624|     647|       4
---------------------------------------------------------------------------
  624-  647 (41.68/27.01)	DDETIRK.....ERWL.KRARRKFCKQEI..K
  657-  684 (23.62/11.99)	QKQFVKR...slKRAL.TRIRLTAEKDSIveK
  699-  728 (27.44/15.17)	EDKSFEKslvlmEKELdKLDMNSFCSQHE..K
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     439.29|     158|    1245|     749|    1014|       5
---------------------------------------------------------------------------
  101-  191 (99.43/22.51)	EERLKEIERQR...AEVTNPEEYDSDVVtDPEVEDKEKLVDneiPKMVLIEIDNVR....MLYPSKLICVTLDDdrQMLEAVGLKTAPIPAELQ.....FPIP....................................................................................
  755-  933 (241.04/265.70)	EESESEIDEQRtglGEGTSDQYQEGDSV.DMIQEDEEQFND...PSMEVPSISHIRtvgdHIGPDGMLSPPASN..EMPKGGPLSVGPPSIEAQGLNQIYPTPpsvqmlQGDsaQAHSPGTHGKSRTLPIVSEEDSERITISGDIgsVVDVE.VTDIETNNMqIW.NKTTNQPklSKFlLSSRNNPI
 1995- 2073 (98.83/23.75)	.............................................................................................QKENEQYP.P......EGH..QAPSPVPAGMIHIPETLSEQEKKVQPTLADI..FIDPSiVAPLNAQNI.AWkQRDTRVP..NPF.PSSNQPPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.40|      13|      14|     999|    1012|       6
---------------------------------------------------------------------------
  999- 1012 (23.33/13.88)	LPQMPsVNPGLMTP
 1016- 1028 (26.06/11.55)	LFQSP.VLPPQHTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.63|      12|      20|     941|     958|      11
---------------------------------------------------------------------------
  941-  952 (23.13/24.26)	YDTPMTGTFEIA
  964-  975 (23.50/ 7.49)	YEPMVTRNFEYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.85|      15|      19|     224|     238|      13
---------------------------------------------------------------------------
  224-  238 (25.79/15.34)	RKRKETLKTFGNKGR
  244-  258 (28.06/17.40)	QKPSETFLTWGTRDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.71|      17|      19|     469|     487|      14
---------------------------------------------------------------------------
  469-  487 (19.94/18.99)	NfDEELIKEiPEIEIIEKE
  491-  507 (32.76/19.01)	N.DVRLTKP.PHDENYEPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.94|      47|     111|    1599|    1650|      17
---------------------------------------------------------------------------
 1599- 1650 (73.83/56.84)	DLLGVVTPTLEvSMKQARHIP.PetefIIDGPLTWRQIVAKAYSGK.PASEDEE
 1712- 1760 (79.11/47.36)	DFMDAVTDTYE.TMRLGHHIPfP....VSTGTATRFRNVYKSFQQQyPYTEHQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.32|      24|     936|     349|     374|      18
---------------------------------------------------------------------------
  349-  374 (38.41/27.38)	KPLKERQKKSNQKSPKGLKQgyGLLP
 1288- 1311 (42.90/23.66)	KNLSERDKLKFTKRQKQLKD..GLMP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10531 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APLSLPQMPSVNPGLMTPTHQLFQSPVLPPQHTPSPFSAGPLGHHPMVPPGYPGTPGTFPPTTPTYSGMTPRPGSTFGPGHVYPHPHHMGAPGYPGQMGPIGPMGVPPMGPMSVQRQFSNPQMLQHHQMQMRMQQMQQMRQMAAQGVPPGYGAPGMPSYPQGAATPGPMGLGMQSGPSSVQRLNNFVNQSQFGPSSVQSMQYGANPSMIPQSPNFNQPYGGMVNPMMSPMQQHQFHQQQMLQQQQHHQHQMQMQMQRTQLQLQHTQSQQAIQTLQPNPLQLLAQQNEQVANAHKNLSERDKLKFTKRQKQLKDGLMPTSLQPTAIKNLRNPPDANVPYKRHEIFNRSPDH
2) DQNIFLTKMEDPMIKEDGKGKEENENENDDDDEDEEGNEEEEEAEQEELL
3) ESFLSTKEVIKDKNDPPNATVRPDSDDEAHQIDKL
4) FGVPLPSGLIEPDYETSPHGSIDEESESEIDEQRTGLGEGTSDQYQEGDSVDMIQEDEEQFNDPSMEVPSISHIRTVGDHIGPDGMLSPPASNEMPKGGPLSVGPPSIEAQGLNQIYPTPPSVQMLQGDSAQAHSPGTHGKSRTLPIVSEEDSE
5) GYYEREGILRVGKPLEPNRSQQTVVNTLEFE
6) INDELEEKKRQRQKENEQYPPEGHQAPSPVPAGMIHIPETLSEQ
7) MQIEEKEPENVTEERQKTPDAEPPAPPQTTRVLLASSSDEEPTTGGYDGADEPKPEDIPVKLRWMYEHDFRQEKPKDETPEEKERREHAREVRRKRRKNREERLKEIERQRAEVTNPEEYDSDVVTDPEVEDKEKLV
8) QVLNYTNSQLRSMPQKVAGEPDPLDTNPANWTS
9) YHKKRMPKPLKERQKKSNQKSPKGLKQGYGL
995
270
428
732
1849
1983
1
1760
342
1344
319
462
885
1879
2026
137
1792
372










Molecular Recognition Features






MoRF SequenceStartStop




1) KGLKQGYGLLPARPWYS
2) VLLAS
3) YDGADEPKPEDIPVKLRWMYE
364
32
47
380
36
67