Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MIKTDERSLRDLLLESADDLEHVLKMIVDTLINRERSVMLKSGESVTNIIRLFDSKQEDLRALLRKVPEYQEREQLIRTLKTHVEKRDEVIQKVENNLKACEVALTRSSFHANQKTKKMQEAALRPVNSETLIKLSHQISKHNSVSAPLTWQMGDPSRPFPQEHEFRAGHLLNAKMQALLPQLLPGKNVAQKPLVSSPSSSNGGSAPLRNIGTPLVNSETPGEFSPRTGYNGEEPDALQQQVMRGATPNEKQFQNASTSGATSSQSPFARISQSPSSSPNVKLKITGLPNRPGGLDQVQEVRDVEQMSSDSSNSSDSSDDEGTSKKTGRSNKS |
Length | 333 |
Position | Middle |
Organism | Caenorhabditis tropicalis |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.768 |
Instability index | 59.73 |
Isoelectric point | 8.84 |
Molecular weight | 36785.85 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP10523 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 259.08| 79| 86| 108| 193| 1 --------------------------------------------------------------------------- 108- 193 (122.83/85.77) SSFHANQKTKKMQEAALRPVNSETLIKLSHQiSKHNSvSAPLTWQMGDPSRPFPQEHEFRaghllNAKMQALLPQLLPGKNVAQKP 197- 275 (136.25/77.27) SPSSSNGGSAPLRNIGTPLVNSETPGEFSPR.TGYNG.EEPDALQQQVMRGATPNEKQFQ.....NASTSGATSSQSPFARISQSP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 54.71| 18| 24| 36| 58| 2 --------------------------------------------------------------------------- 10- 27 (27.19/12.84) RDLLLESADDLEHVLKMI 36- 53 (27.52/21.67) RSVMLKSGESVTNIIRLF --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) NVKLKITGLPNRPGGLDQVQEVRDVEQ 2) TSKKTGRSNKS | 280 323 | 306 333 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab