<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10514

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMTDEDWPSPKFREHVIQRLEPELARNRQNAPNLPVPGDARQVEEYVFAKCMSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSQFHSPPCTTPALGGTTPVGGTPGYRAPVPPDPQPTSAQARNPPPAVATTQATTTPSSQNTVSAGTVSASAAVAAAVANFPSPEASLRPGGQTTPGAPSQQANGPNGQFQNGGPPGGPSMNGGPAMGQPPPQMGAPNMGMGGPPGAYGGYGMMNGPPGNGGPMGGNPYGQGMKKEIDQSRPWDPQGHMYQQPWGGMPPQQGHGYPNRPPMNGQVTTPTGTSSVLESLINQPQQYPGHNQMGPPGADRNGPGARPGPPGNQPQRPGMQNGNNQGVMSVEDQNIYATKLRNMRGSCESLRTRARQCRNEGNHEAAHKLEVMLSVLEGKRVVSLEYLNHLETWIARKQDFLNINPMAPNPNHMGMTDPVMNGDHGMMGNGQVHNPYGGQMGYGHGQYMGGPPPPHHMQMHQQQMWHQQQQPQQRMMPQEHMMMPGGGPMHGMYRNDMGHDQMTSPVNNHRHAPYQNPAMRNNMRQMPNGAGPIGRDRNSMSGSMSGPSSGAPTMNPMGTPTQKMGTPGSMSGLSGLDDFQYDDFLPNPIDALQPTLHVGNPQNSMNPGQSVQRSSLNDSARKELQALEARFEIDQSHPRHDANHYIVTCKLRNQPFPPLRLVVPTQYPSGNVSVDRSAIDLDAYLYDELQNVVHDRLSRPGLTTLTDFLNTWEEQVNQYVQQNQTNGGMDPSFGVGNDFFYDNLNLSNAF
Length779
PositionTail
OrganismCaenorhabditis tropicalis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.06
Grand average of hydropathy-0.849
Instability index51.84
Isoelectric point6.60
Molecular weight84182.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10514
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     677.77|      95|      98|     163|     260|       1
---------------------------------------------------------------------------
   82-  147 (72.04/11.61)	....................PSQFHSP.PCT..TPALG..GttPVGGT........P..............GY...RAP...vPPDPQPTS.AQ.ARNPPPA.VATTQAT.TTPSSQ..........NTVSAG.......
  163-  260 (191.08/48.71)	P.SPEASL..RPGGQttpGAPSQQANG.PNG..QFQNG..G..PPGGP..SMN.GGP..............AM...GQP....PPQMGAPN.MG.MGGPPGA.YGGYGMM.NGPPGN..GGPMGG..NPYGQGMKKEIDQ
  263-  362 (135.99/30.00)	PwDPQGHMyqQPWG....GMPPQQGHGyPNR..PPMNGqvT..TPTGT..SSV.LES..............LI...NQ.....PQQYPGHN..Q.M.GPPGAdRNGPGAR.PGPPGN..QPQRPGmqNGNNQGVMSVEDQ
  373-  474 (90.01/17.02)	R.GSCESL..RTRAR.......QCRNE.GNH..EAAHK..L..EVMLS..VLE.GKRvvsleylnhletwiAR...KQDflniNPMAPNPNhMG.MTDPV.M.NGDHGMMgNGQVHNpyGGQMG.....YGHG.......
  475-  530 (75.78/12.67)	.................................QYM.G..G..PPPPH..HMQmHQQ..............QMwhqQQQ....PQQRMMPQ...............EHMM.M..PG...GGPMHG...MYRNDMGH..DQ
  532-  619 (112.88/23.48)	T.SPVNNH..RH.......APYQNPAM.RNNmrQMPNG.aG..PIGRDrnSMS.G................SM...SGP....SS..GAPT.MNpMGTPTQK.MGTPGSM.SGLSG......LDD..FQYDDFLPNPID.
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10514 with Med15 domain of Kingdom Metazoa
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