<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10510
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MKPQGNENDLSETMDGFPPPIPPVTANYQSEPEKINQATDMMIKRVTDAKKMIEELLQMLDMQEKCPWPDMLEKFSSLASAMSGLQSSVRKSGLPHGHEDYGQFLRSHVLVPQRLQYENDEVLQRATQGRVFSWNHALVPEYLRTKPNPEMDNEESMLDGERSAKAADLVVRQIAAYNKNIEGLLNNLTTIDRLHTEAVTEKPTHNRDETTKLVKSILTGEAIRTVRATQPPPSSTPMMQMPGSSGAMSSQSSSQGVNSGTGMQDYQNSQLRQQLMGPGSGQAQASQSHGNYSSSFQPQYQQHQQQLHPQQNPNQMAFQE |
Length | 320 |
Position | Head |
Organism | Caenorhabditis tropicalis |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida>
Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae>
Caenorhabditis.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.848 |
Instability index | 59.98 |
Isoelectric point | 5.63 |
Molecular weight | 35768.58 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP10510
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 59.42| 19| 36| 85| 113| 1
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85- 113 (24.48/34.31) LQSSVRKSGlphghedygqFLRSHVLVPQ
123- 141 (34.93/20.00) LQRATQGRV..........FSWNHALVPE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 102.39| 29| 33| 242| 274| 3
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242- 274 (46.01/27.20) PGSSGAMSSQssSQGVNSGTGMQDYQNSQlrQQ
278- 306 (56.38/24.05) PGSGQAQASQ..SHGNYSSSFQPQYQQHQ..QQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 64.07| 20| 32| 184| 203| 4
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184- 203 (32.10/19.18) LLNNLTTIDRLHTEAVTEKP
213- 232 (31.96/19.07) LVKSILTGEAIRTVRATQPP
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