<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10505
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MSSSEISNFAKQDSLSLRSENPPVNPLTQVSSPVIGERKRRATDDATPTDWKSSRPKLEQTMTDDDWPSQNFRDHVINRLEPELARNRQNAPNLPVPGDARQVEEYVFQKCVSKDEYMRTIAKVINAINCNSKTVVVPTVIHNGNNQANTTSPGQTATANNVLGNKPQMRPQVPPDPRPTHQRGLNLDIQNGSRFQTPPLGQPPPPQMSSPITSSLPNPMKMPPVQNPPPNQYANYGQYNNNPRMPSGNQYGAPMPENPIGYNNIPPKGYDSMATKMEPAVPLGQSNSVEQQMMQQQQRMWTPNGPADQLTGRPIYPNQVHPGLLNDYDLPPNIACHFKRPEDARAYKEKIRTLSKYTNTIRNMIQIANPESATKLQFALEGITFQKFMSQENIKGIESFVQRELSHQQQPYRENMNMMGDQMMVNAPPMNAYGQTSMASNWQQNPWPQNVQGSATNPNMMPQNHSQYAPPGSYASSSSVYGQPTPQPLSTGRPSPYPLPPHHKMYSTGGIMQQNHHQPMTQQPSSYQQPYQYMPPQPLPMSSQPNQMIPNSQPSQMNMTYDDQLQCPPMDATNMMPRGYDGNLMQAQVTTEMGVGGGVLMKLPEQARTEFANFDQNISYISVEPSNDGMYFIVVCALKREQIPNLRVSVPRNYPNQLATVERAALDLDSFYFDDLQNAIHEQLSKAPMHSVTDILNIWENTVMQFFNNQSLGGGGFDDLLTGTNFGDLT |
Length | 730 |
Position | Tail |
Organism | Bursaphelenchus xylophilus (Pinewood nematode worm) (Aphelenchoides xylophilus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida>
Tylenchina> Tylenchomorpha> Aphelenchoidea> Aphelenchoididae>
Bursaphelenchus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.828 |
Instability index | 60.51 |
Isoelectric point | 6.14 |
Molecular weight | 81778.87 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP10505
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
6| 275.30| 33| 34| 201| 233| 1
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201- 233 (65.86/18.57) GQ.PPPPQ..MSSPITSSLPNPMKMPPV..QNPPPNQY
237- 270 (44.17/10.19) GQyNNNPR..M..PSGNQYGAPMPENPIgyNNIPPKGY
278- 310 (38.86/ 8.13) EP.AVPLG..QSNSVEQQMMQQQQRMWT..PNGPADQL
443- 474 (43.36/ 9.87) QQ.NPWPQnvQG...SATNPNMMPQNHS..QYAPPGSY
482- 506 (44.01/10.12) GQ.PTP......QPLSTGRPSPYPLPP......HHKMY
552- 580 (39.04/ 8.20) SQ.PSQMN..M..TYDDQL....QCPPMdaTNMMPRGY
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.70| 21| 116| 406| 428| 2
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406- 426 (41.67/17.02) SHQQQPYRE......NMNMMGDQMMVN
525- 551 (35.03/ 8.93) SSYQQPYQYmppqplPMSSQPNQMIPN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 306.26| 77| 336| 316| 393| 3
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78- 134 (63.18/36.56) ..NRLEPELARNRQNAPNLPV....PGDARQVEEYVfqKCVSKdeYMRTIAKVINAINCNSKT......................
316- 392 (136.61/85.83) YPNQVHPGLLNDYDLPPNIACHFKRPEDARAYKEKI..RTLSK..YTNTIRNMIQIANPESATKLQF....ALEGITFQKFMSQE
654- 724 (106.47/69.30) YPNQLATVERAALDLD...SFYFDDLQNA..IHEQ.....LSK....APMHSVTDILNIWENTVMQFfnnqSLGGGGFDDLLTGT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 27.86| 7| 17| 43| 53| 5
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43- 53 (10.70/13.26) TDDatptDWKS
63- 69 (17.16/ 7.68) TDD....DWPS
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