<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10497

Description Uncharacterized protein
SequenceMSSASTPHVFSIHQVGAEKRPFRKHKMPPDVYPQDPKQEEDSMSTERLRKGFIVQVPACESDSYVAKNAKSLEDALSRASKLIKNVIQQKDEHNKFQLDKKKQKDFTFQGFYNPSAQKDKSNWYDELAKGRGLSALVKKLPSIKKDGLEVLFQSKVPLPRAIWCIKMNQIGMMLQQTQQNRVKKQLDQIKIVASFLKGQLKKLDNPQLSASEITQIYQRWPYYLTLFKNCFEEGVLDRQEFLFELCDLLTEYMNFPLDRPHVFRLLINFTANFVDIAVQNVIVARRFGYICAYRLDKYLKDYERRFGAYSDISEVISEYEHCAAHRVIILTLSGMLRALIIDCPAAFVWNPSDVKSGTPDQLAGSPLDKFSRVEQFLLDCYFPSIPRAKEILKRRLHEIRSRSQNVENKWARESGSQKGFYRIVNLCISVVSALDMFEATAKNSFSNLYKTVFNESFSGSVDAENQMEMVFRIKCCLQWAIISEREGTYRALVVAKLLALRVALSETKNFSPFCGFKLQDLLIDYITHDAPQIDQPNYRKEYGNMIHLFMELQRFGLFCHDSYVRSLLRCGLLNSPIVQKIVELNPGSSFSPTKSIDDLERQDSSTPVKHAEPVGGVISFIPPVDNSPMPVLQKPKCDRQLIPVLHDVENYIDTFESDYMPGFIASQMAYVLCSYLAAHSDYFFCSKGAPEVVLSLSKTFDQAIRGQGYPQTGWSRSVIQFIWNARTILIDAGLVSSHQLHGLKQDFRRNFYEDIPRSTPETLKYNPELWMDMLDGVKRVFDYELYKLHLPSVEDDHSRYSFVCNVFKKAMELKNDMEKLTELANFCSHVAAQKHIASTLYNCISELCNPSQSKKMFIKEIGVNIDDPSVHYSLSVFILLLAARYCFSVHVLIHTLIYNVVIPTVHDDSPRTIAQNVNGLCLTLRILTGLVTASDRPFQLKAEESRVQKPLGQIRALRMLQINEMDKIIFPLLSAVALLNENVKKDRNNRPLLTAIVKCSLLAMCEEEWVAKRMFWICENDLATETDQKQKKDELFSCQKLKDNSVGQHLLRLALRRRAERKIKNELIICKANSRKSLLEKLLTTMNLWNFNATFFDLRQMIKENNPEPQSKHANQAAVQADILNNEIARCCGELFGKFQMDQPHLLEPPPLPDLKLSHLNCYWLIAPLIKRCPQPENMPANFVNCSVKGKFLKDTATRLENSKREEAKTQKSTYFLNQPPFVNLVLACLEGEEQQGDGLAAALLKQLQELVNRVKEDSTIPHSHSFITEERTDLLLRLNLLGGMFDTLKQSSVDLWALVLFQLLYYNIITPEKDKEHFDSTFDMLSMLVHSTLATTQDADRRNEALRCRSPTYNTVVKKIRKELGERPIPPDLHCLQQLLPIQRRKLADNSAWDLFGYQNQQKTKGSPENKNNRIPVAEFAYPTTATRIDRFPQMAQKSIVQLLQHTHFKDYKMPGIWGCKMDRQQNDVFLQLPEVEHDPDEPIPNPMQQQQYGQPMGQAQHPHPSASFHQPPPQQMPPPNSSMIQNHMGQQMPGQLGNPMSNQMSGAQMGGQIPGAQIGNMPGPNQMGNMPGGQIGNQMPGGPQMGGQMPGGPPMGHQMAGGNMMGQVQGTVPMPTPLGQPSNMPGQDFRSQQPQMPMGMQNPIGMAGRMPMGMGAGTPSQDTPPTPSSGRGGRGRKTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGRKTTTPTQRGTKRKSKTNLMDLAPDQPQHPTTANFPHAPPTHHAQQQMLQQHQQYTQQQQWQMQQMRMNPQQPQRMPQQNPPPPGPQTMPSAGQMQQGPGMQSETKHQLQDAILRRQRNQQMHQNRP
Length1909
PositionKinase
OrganismBursaphelenchus xylophilus (Pinewood nematode worm) (Aphelenchoides xylophilus)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Tylenchomorpha> Aphelenchoidea> Aphelenchoididae> Bursaphelenchus.
Aromaticity0.08
Grand average of hydropathy-0.501
Instability index49.57
Isoelectric point8.91
Molecular weight205795.37
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10497
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     457.10|      43|      44|    1513|    1555|       1
---------------------------------------------------------------------------
 1372- 1424 (39.30/13.43)	P....DlhclQ..QLLPIQ..RRKLAD.NSAW..........DLF.G..YQN.QQKTKGSPENKNNRIpvaefayP
 1433- 1475 (42.67/15.22)	F....P....Q............MAQK.SIVQllqhthfkdyKMP.G.IWGC.KMDRQQNDVFL..QL.......P
 1481- 1513 (61.12/25.02)	P....D....E..PIPNP.....MQQQ.QYGQ..........PM..G.QAQH.PHPS....ASF..HQ.......P
 1514- 1556 (90.94/40.87)	P....P....Q..QMPPPN..SSMIQN.HMGQ..........QMP.G.QLGN.PMSNQMSGAQMGGQI.......P
 1557- 1592 (55.47/22.03)	G....A....QigNMPGPN.........QMG...........NMPgG.QIGN.QMP...GGPQMGGQM.......P
 1595- 1634 (47.77/17.93)	P....P..mgH..QMAGGN....M.....MGQ.....vqgtvPMP.T.PLGQ.P.SN.MPGQDFRS.........Q
 1635- 1659 (30.75/ 8.89)	Q....P.......QMP.............MGM..........QNPiG.MAGRmPM.......GMGAG.........
 1822- 1855 (42.98/15.38)	PthhaQ....Q..QMLQ.......QHQ.QYTQ..........Q....qQWQM.QQMR......MNPQQ.......P
 1856- 1899 (46.09/17.04)	Q..rmP....Q..QNPPPPgpQTMPSAgQM.Q..........QGP.G.M.QS.ETKHQLQDAILRRQ.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.77|      57|     247|     228|     317|       2
---------------------------------------------------------------------------
  240-  302 (85.51/102.51)	EFLFEL.CDLLTEYMNfplDRPHVFRLLInfTANFVDIAVqNVIVARRFGYICAYRLDKYLKDY
  468-  525 (94.26/43.65)	EMVFRIkCCLQWAIIS...EREGTYRALV..VAKLLALRV.ALSETKNFSPFCGFKLQDLLIDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     300.42|     100|     259|     724|     855|       4
---------------------------------------------------------------------------
   11-  127 (150.15/93.06)	SIHQVGAEKRPFRKH...KMP...PDVYPQDPKQEEDSMstERLRKGFivqvpacesDSYVAK.NAKSLEDALSRASkLIKNVIQQKDEhnkFQLDKKKQKDFTfqGF.YNPSAQKD.KSNWYD...EL
  736-  847 (150.28/146.59)	SSHQLHGLKQDFRRNfyeDIPrstPETLKYNPELWMDML..DGVKRVF.........DYELYKlHLPSVEDDHSRYS.FVCNVFKKAME...LKNDMEKLTELA..NFcSHVAAQKHiASTLYNcisEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.08|      31|      50|    1137|    1168|      12
---------------------------------------------------------------------------
 1137- 1168 (56.52/41.47)	GKFQMDQPHLLEPPPLPDLKlSHLNCYWLIAP
 1190- 1220 (52.56/33.58)	GKFLKDTATRLENSKREEAK.TQKSTYFLNQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10497 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DVFLQLPEVEHDPDEPIPNPMQQQQYGQPMGQAQHPHPSASFHQPPPQQMPPPNSSMIQNHMGQQMPGQLGNPMSNQMSGAQMGGQIPGAQIGNMPGPNQMGNMPGGQIGNQMPGGPQMGGQMPGGPPMGHQMAGGNMMGQVQGTVPMPTPLGQPSNMPGQDFRSQQPQMPMGMQNPIGMAGRMPMGMGAGTPSQDTPPTPSSGRGGRGRKTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGRKTTTPTQRGTKRKSKTNLMDLAPDQPQHPTTANFPHAPPTHHAQQQMLQQHQQYTQQQQWQMQQMRMNPQQPQRMPQQNPPPPGPQTMPSAGQMQQGPGMQSETKHQLQDAILRRQRNQQMHQNRP
2) PHVFSIHQVGAEKRPFRKHKMPPDVYPQDPKQEEDSMSTER
1469
7
1909
47










Molecular Recognition Features






MoRF SequenceStartStop




1) YLRIFQ
191
196