<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10484

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMLPQNVSPYPSPPEYALNYTNDNIRSGSIPKPPPVPLKFKVFNEEYNLEGPMMPSLQDLEITKYYNSKEPWKAELRKLNFSVVAAFLDLLDILIKNPQHPERKEKIETIRTLFINMHHLINERRPVQARETLVEMMRKQNRDLSNVITRLKLLLSNVGSKLNEMHKEIEECTIELTIPECSTSSISPPEHKVMTYNIIQDRRLTKKQVKMQEFKCKDEALLKHMKLLTLAEEDKTEYTDTFNDDDLADVEENVIDEEENEESTLSESSEINEDDFIEDDKSSESEEAVKDSVMDVTVEYMDDDEDDEDEDEEDLDDVMDDSDEDKASGSPQSAISAENTSGLEPPSEFVDDKPRPEEPMEPEINMMPEQENSQQFPMSPELDNQNDSGDNSDPEAVQ
Length397
PositionMiddle
OrganismBursaphelenchus xylophilus (Pinewood nematode worm) (Aphelenchoides xylophilus)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Tylenchomorpha> Aphelenchoidea> Aphelenchoididae> Bursaphelenchus.
Aromaticity0.05
Grand average of hydropathy-0.930
Instability index73.22
Isoelectric point4.24
Molecular weight45687.98
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


ECO:0000256	RuleBase:RU364060

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10484
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.42|      21|      24|     274|     294|       1
---------------------------------------------------------------------------
  274-  294 (32.93/12.03)	DFIEDDKSSESEEAVK.DSVMD
  298-  319 (28.00/ 9.26)	EYMDDDEDDEDEDEEDlDDVMD
  347-  363 (22.50/ 6.17)	EFV.DDK.PRPEEPME.PEI..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.21|      20|      24|      86|     109|       2
---------------------------------------------------------------------------
   86-  107 (26.18/21.29)	FLDLLDiLIkNPQHP..ERKEKIE
  113-  134 (29.03/10.16)	FINMHH.LI.NERRPvqARETLVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.02|      19|      21|      12|      30|       3
---------------------------------------------------------------------------
   12-   30 (35.71/18.86)	PPEYALNYT..ND..NIRSGSIP
   32-   54 (28.31/13.62)	PPPVPLKFKvfNEeyNLEGPMMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.33|      14|      26|     231|     244|       5
---------------------------------------------------------------------------
  231-  244 (25.42/16.13)	EEDKTEYT....DTFNDD
  256-  273 (17.91/ 8.96)	EEENEESTlsesSEINED
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10484 with Med7 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EDKTEYTDTFNDDDLADVEENVIDEEENEESTLSESSEINEDDFIEDDKSSESEEAVKDSVMDVTVEYMDDDEDDEDEDEEDLDDVMDDSDEDKASGSPQSAISAENTSGLEPPSEFVDDKPRPEEPMEPEINMMPEQENSQQFPMSPELDNQNDSGDNSDPEAVQ
232
397










Molecular Recognition Features






MoRF SequenceStartStop




1) EFVDDKPRPEEPMEPEINMMPEQENSQQFPMSP
347
379