<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10477

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMSVLGLKSDGPVSWSKTGLIAYGETDSSDINLCVTFLETINGTNWRFHPPKKYIIHPHMYDKKPLSNGNAINGNGSVAKPQKAFYNIRSVHWNNSISLSGELLAVCDEVGNLTILMAGQSIQGPSTLDNMIVLFQDNIYKIHNQIIPLDEAVIGSKGVRKGNKRECHTSIINFQWLSSQKPVIVMLGARKDPSTDTFKSQVQQSPPYGIFHPTSIKSACIAIRRNGQLDFWYQLSNSKDHKKISLQLSSSQDPWNKEQDWLEFGQCAHMNEEQTMLIGVYSRLNRKFAFYKLSVNWNVNTANAINDPSLKLQHLNDLIPDSLGPNGEILQLNNFHITSRTHEKSSKPEILICYKVVGSSRSIVKRLEISTSVPSSELTLVFGTLTSNSSTSTPSKYTVKEVGGLQFDSPVSAVTSRILDSIIIFRLDNGETKVFNRQNWTTEADAKNVSSRGQPNTNITSLFCTGLQFPLLPPFDAIEWIKISPALGGVIAKLKFKKNPCFYSLFSDASKDEKHDSSIAAAFAYGFVVSNHRQMSGEDLSIAMKTHALKLGQFNKKRAERFITSAISSVYHLFGLSPDSPRELKDKLIMSRPIQRAMLLQLELGSSFINSNIYNISRVVMSLRNILFAFNGVSRNVQVLIHHTATMNVHQSNGKLFQFAFSKQDLIYSLIPCAKWFVKFITFLTQQMIVLVNNPNDTENTLVLGILSSKMTRTLILSVLNEMKKIIQLVTKFPETIYPVLNESSVYLRKVLGDSPVNFEKFETFLVDVNNKFIALSEQQPQLSSQKEPYLVVQGEIPEDIIQIKDFLLSYSNTAVLSHTKPADVYFTDTSGLRIFASEYFSKPIFKLLQPIEEGLVVDNETLPPNFKTARSFSVIEFDDISNDKLTSGKDAKIKRCCRCGSVTCAGYTVSKESTIVPTSISTKRWTNLYSKICVCSGFLYELH
Length943
PositionTail
OrganismLachancea fermentati (Zygosaccharomyces fermentati)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.09
Grand average of hydropathy-0.167
Instability index42.82
Isoelectric point9.04
Molecular weight105688.02
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10477
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.70|      51|      59|     179|     235|       1
---------------------------------------------------------------------------
  179-  235 (80.04/60.27)	QKPVIVMLGARKDPstdtfKSQVQQSPPYG.IFHPTSIKSACIAI..RRNGQLDFwYQLS
  240-  293 (82.66/46.72)	HKKISLQLSSSQDP.....WNKEQDWLEFGqCAHMNEEQTMLIGVysRLNRKFAF.YKLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.04|      19|      59|     388|     406|       2
---------------------------------------------------------------------------
  370-  389 (26.97/15.36)	TSVPSSELTLVFGTLTSnSS
  390-  409 (29.07/17.09)	TSTPSKYTVKEVGGLQFdSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.20|      36|     472|     137|     172|       8
---------------------------------------------------------------------------
  137-  172 (62.29/44.88)	NIYKIHNQIIPLDEAVIGSKGVRKGNKREC.HTSIIN
  611-  647 (55.92/39.51)	NIYNISRVVMSLRNILFAFNGVSRNVQVLIhHTATMN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10477 with Med16 domain of Kingdom Fungi
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