<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10475
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MLTEGQKGDAKECSSPFKGISLALDPNLINLVPSGATTVPESENELDKQEEVEVANAPSQSLINNPYEMFEKMPLSRLIPIILRNRGPNFKFADLTEDALLKEISGENNEQTIEKDADGDYKMGSESIDELKGREESLQPLRVDENSLTDESESVSQDQFQQLKKNVIQSINMALNESSLSLEFVSLLLSSVRPAAATASMSPYLKKTVPAASLNAEKIPLKRSTRSEVISSRITHKGWKLRSLEESRLLLKETYHSLERSIEKEHDYWSKICQYISNKDVVFKMKDRDTGERSLGIKYGYEDSGSTYKQDRGIAILRHDSKMNKLELVPFEKSQSAVHINKRNNEKFLRVRIFTKIEEEDDYILTGESCLDSVLATSEDSTQEVDIRHQISKLKFFIFDQELMYQLKRESETLISYGVSIENENKIVAEFPSEKIEIEMLQLDDDIIMNHQQDAPKTNDKKANLILTMLRLLLVIMYKKQMRQRLLSPPSSKRTHSKSSKTRSSSKDASDTSILLLRPIMGKIRHQSYLDLLKKLTKDFILDAVKDSKLTVISGNERSNSDISNTDSDIHITKLNKEIGMFDEILRMPRSEISVDLNEKGKIKLVLESSNFCNAVIKVTYVNGTAKALFDTKFSDFKELEEFLHFIINEYVV |
Length | 653 |
Position | Head |
Organism | Lachancea fermentati (Zygosaccharomyces fermentati) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Lachancea.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.526 |
Instability index | 58.91 |
Isoelectric point | 5.60 |
Molecular weight | 74413.82 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP10475
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 331.54| 111| 148| 58| 187| 1
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58- 187 (158.71/135.77) PSQSLINnpyemfEKMPLSR.....LIPIILRNRGpnFKFADLTEDALLKEISGENNEQTIEKDAD.....GDYKMGSESIDELKGREESLQPLRVdENSLTDESESVSQDqfqqlkknviQSINMALNESSLS.LEFVSL
210- 331 (172.83/105.18) PAASLNA......EKIPLKRstrseVISSRITHKG..WKLRSLEESRLLLKETYHSLERSIEKEHDywskiCQYISNKDVVFKMKDRDTGERSLGI.KYGYEDSGSTYKQD..........RGIAILRHDSKMNkLELVPF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 44.25| 14| 141| 387| 400| 4
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387- 400 (27.86/18.77) IRHQ.....ISKL.KFFIFD
524- 543 (16.39/ 8.16) IRHQsyldlLKKLtKDFILD
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