<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10471

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMESMDSKFRLEEVLTSYYRIQKVDKVNYVQFVPNKPDAQWSIQAELILRKQNPQVLVALFSRELWCFSLNDDDLPSPKLENPTDTPQPDKQGHFTPDISKPNLPTPYAIFLKALRRTIHVNLCLESQSKLIPFGNSCLFRQYNNSNKIVHFEPHLFENGDLCLSVCTKDMDITNLEMSKVKGMFSKENALYLAPSGIRGYLFSTDQSKCFSPPPKNANVLLLTLLVSHGIDLTHKEDLRWVKVIPSLDHLNGYTPSIAGYLDPPKATKTVIWPYDLCYVQSSLEANKNIFRSPQLEANLQETFDIIDDFIQLKLTSAFRTSGSIGVGSGTGTATGNNPTGTGGIYTDQFQQFHKHSASSGQNVLVPPMSQGQTKGSPGGALNLTPGGTSRSVPSSADNFNNGFLTTPNINENVESTIDDLMLNTPSVKVQNDLWNERKEETNNREVDEVKQSMNSDVPTINDEEIDNETDLFGDDEDLFGQQSESNSPEQHEIKEITDEMFDLANESDSSNSKLSPEKQPSAPNSTQTPSKRKYLDIPLEEITLPSTPLYTDPGAPLPVETPKDRKKSVFAPLNFNPIIESNVDNKYKNGGKFSIDNGRNEEPLKFDVSTANISSSEDDESASSGEDFDDIGVDHRQDARSIDMNIPMSNFTVDGQPRSITEMIQTDVPKEDSLLPMYENDLHSKKLMRENQLEIWRSPNEGSQEYSPSRLSSQLQPSRQADSGGGATETGDLLKYGHLTPLFEQPSKFTAVGKPTNVDRAPEVSSETVKNGGSSNSSDNLIPPESSNSLPFLLRHMPLFSIPEAFMSHNPSLPRENLQALLDILVEQIVFDDGILGDLGIKEAPFNGFKGCKDGLVKDTIQKIFPLFERLHGNEIIEEMYFLKQPPVYVKKNHDIIKINSDAESFSQYLHLKPFKGIKNFKVLFLTTSLKEDCIDFLSLISQTYSSQDLGFCELIKLTSEDTQGLIYLINFEKDILSLLSAQIVSYCSTNTRNMTSVPLVILLPINTPEVSEIISMVLKFQFIKNEVLSKLPKAQLILKLIPMDFIKNPLTSVESYNNLCVGIYNMLPPKQIKFTAIADELPEKVEFRTLQQSNGQAVHFDGYIHLAYARSIDRNWLCASWSNSTGSENAIRAWFIGNSKTAFEEVCNQMWRITLNFAATKYGRICLVLTRLDSVLPDDELMHWRRLSASARNLHLAVVCVGENTKLSLYDEDKLYPSFKPIIRDEKFSRNIDSNNLDDYEIVNVDDAVHGVLFEHPLQLANSQHRCAIKTGALIKFKISEGNEILDKLDVNLLNCPHSDCARLLKIILQEFRNLAALSSWFGITKSENGHIPWHILAVKKMITFIVHARVDAETV
Length1357
PositionKinase
OrganismLachancea fermentati (Zygosaccharomyces fermentati)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.08
Grand average of hydropathy-0.396
Instability index43.32
Isoelectric point5.12
Molecular weight152238.30
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10471
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.83|      24|      28|     462|     489|       1
---------------------------------------------------------------------------
  462-  489 (38.46/35.65)	DEEIDNETD.LFgddeDLFGQQSESN...SPE
  490-  517 (34.37/20.69)	QHEIKEITDeMF....DLANESDSSNsklSPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.74|      26|      28|     646|     673|       2
---------------------------------------------------------------------------
  646-  673 (41.21/40.12)	IPMsnFTVDGQPRSITEMIQTDV...PKEDS
  675-  703 (40.53/31.08)	LPM..YENDLHSKKLMRENQLEIwrsPNEGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.39|      12|      27|     127|     138|       5
---------------------------------------------------------------------------
  127-  138 (22.26/12.28)	QSKLIPFGNSCL
  152-  163 (23.13/13.07)	EPHLFENGDLCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.40|      26|      33|     563|     593|       6
---------------------------------------------------------------------------
  563-  593 (40.67/34.93)	KDRKksvfaPLNFN....PIIESNVDNKYKNGGKF
  599-  628 (38.73/22.06)	RNEE.....PLKFDvstaNISSSEDDESASSGEDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     345.37|      93|     642|     228|     324|       7
---------------------------------------------------------------------------
  228-  324 (152.12/112.38)	HGIDLThkEDLRWVKVIP...SLDH....LNGYTPSIAGY..LDPPKATKTViwPYDLCYVQSSLEANKNIFRS..PQL.EANLQETFDIID....DFIQL.KLTSAFRTSGSI
  771-  836 (80.76/47.97)	..............................NGGSSNSSDN..LIPPESSNSL..PFLLRHM..PLFSIPEAFMShnPSLpRENLQALLDILV....EQI.......VF.DDGIL
  872-  967 (112.50/70.94)	HGNEII..EEMYFLKQPPvyvKKNHdiikINSDAESFSQYlhLKPFKGIKN....FKVLFLTTSLKEDCIDFLS....L....ISQTYS...sqdlGFCELiKLTSE.DTQGLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.76|      19|     642|      83|     101|       8
---------------------------------------------------------------------------
   83-  101 (37.92/24.08)	TDTPQPDKQGHFTPDISKP
  728-  746 (35.84/22.32)	TETGDLLKYGHLTPLFEQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.86|      11|      34|     519|     529|      11
---------------------------------------------------------------------------
  519-  529 (21.73/10.56)	QPSAPNSTQTP
  552-  562 (22.13/10.89)	DPGAPLPVETP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.77|      16|      34|     391|     411|      12
---------------------------------------------------------------------------
  383-  398 (25.78/ 8.43)	LTPGGTSRSVPSSADN
  404-  419 (26.99/22.59)	LTTPNINENVESTIDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10471 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KYKNGGKFSIDNGRNEEPLKFDVSTANISSSEDDESASSGEDFDDIGVDHRQDARSIDMNIPMSNFTVDGQPRSITEMIQTDVPKEDSLLPMYENDLHS
2) MRENQLEIWRSPNEGSQEYSPSRLSSQLQPSRQADSGGGATETGDLLKYG
3) PSKFTAVGKPTNVDRAPEVSSETVKNGGSSNSSDNLI
4) SASSGQNVLVPPMSQGQTKGSPGGALNLTPGGTSRSVPSSADNFNNGFLTTPNINENVESTIDDLMLNTPSVKVQNDLWNERKEETNNREVDEVKQSMNSDVPTINDEEIDNETDLFGDDEDLFGQQSESNSPEQHEIKEITDEMFDLANESDSSNSKLSPEKQPSAPNSTQTPSKRKYLDIPLEEITLPSTPLYTDPGAPLPVETPKDRKKSVFAP
586
688
746
356
684
737
782
572










Molecular Recognition Features






MoRF SequenceStartStop




1) PEQHEIKE
2) RKYLDIPLEEITLPST
488
532
495
547