<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10467

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTEEKDPVFELAINCANRHLSAKQFLYFYNELFNEKYGAIVNSGEETEENDKEKDIYRKLADVFLSALNCEGNVLLVEYVVEVLFVNYNSKLVSAVIPHIYSVSNKSSMIHFFTKSGAFFSRLTDKLVMDQVNEDLGTVIIPSVLSAHFNSIEQQLVVSIAKFLRSILRLSNQLIILSSTDTRDNTYMLLSRLGQINKLLYKKVADDFESKLNYENSEPNFPTDYAHNTVSPSIISPKFMHSPLTTSSRDIGKNSTTTAYQDVKLIRYYKNLWLNSKIMNWSANERDFLIKYNSIGASVCGKTTLTDQFNVDIVVTDLIETAFTCFAQFVSNKQYHQSNASFNLLERQWVVFITKQLPLLILENASKMPHTVTNALENIDDKVVKAIKSYYSDKEDTKNRNEDLFDDLPSNNLDIRHDFIKNLIMLKLQPPSILNEYLRDDQVVDIKSLPANDSVMIKNAQGVKELIEDFSQFIKSSIDALEIESIFDGLNGSVGVGNNSIIQILQSFESLAPTKQKEAANVFYDVLYESARNFDSKRLSKICCILTFNLAHSLTSILAFVSPVKFLTVIVEFLDEIWDANMSKINEGLSDETDLESNNEFSSFAYALVFAIHVSKTYGIFIGDVLLSNGHDNLQDSFVATFTTKLGDISDEIRLCTPQNFNDLLKTWVRDLFINGSISDPLMKSANVKDLAVLIPYIFKQSIMSVELGSIRDVSTLIGGFEYFLQPFLIVGLIGIVFWLEHYLTTLKSEEIPTELQQSIFEMLNSVINPAALNDESKPLHVLILRLNAIGLIKTLKFFRTQSQSNYGIYSSDVQGDPKLETLITCLENISSVANFYNIDQRMLTSNGGYSQKQLGYSPFLITNDTPISSIMTNQMNSFRNLHSSTYFNMDYLFALTDIITHERFLEDLLQSLNDNLVTSNTSISRTKGVTGEKGHVLDYIFYFLVIHDVKDSPSKINMLRYMESAEGDYETFMKDKKEPKTESEFKLEQPTDEDFDMLFGEDTSIQGNDTDIISTDNKDKDASVLPNLLLLRNSFGVILHKLKLQKERSYKAGFISKSDLNCFEEYNNKYIELLKRAVI
Length1080
PositionTail
OrganismLachancea fermentati (Zygosaccharomyces fermentati)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.10
Grand average of hydropathy-0.144
Instability index40.01
Isoelectric point5.00
Molecular weight122748.15
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10467
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.45|      36|      59|     369|     408|       1
---------------------------------------------------------------------------
  368-  407 (53.98/46.33)	MPhtvTNALENI.......................DDKVVKaIKSY.YSDKEDTKNRN..EDLFDD
  408-  469 (38.47/21.87)	LP...SNNLDIRhdfiknlimlklqppsilneylrDDQVVD.IKSLpANDSVMIKNAQgvKELIED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.98|      38|      44|      89|     129|       2
---------------------------------------------------------------------------
   89-  129 (59.42/50.62)	NSKLVSAVIPHIYSVSNKSSM......IHFFTKSgafFSRLTDKLVM
  133-  176 (55.55/38.00)	NEDLGTVIIPSVLSAHFNSIEqqlvvsIAKFLRS...ILRLSNQLII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     472.56|     158|     187|     470|     650|       3
---------------------------------------------------------------------------
  470-  650 (229.59/207.64)	FSQFIKSSIDALEIE.SIFDGLNGSVGVGNnsiIQIL......QSFESLaptkqkEAANVfYDV..LYESARNFDSKRLSKICCILTFNLAHSLTSILAFVSPVKFLTVIVEFLDEIWdaNMSKIN.EGLSDET...DLESNNEFSSFAYalvFAIHVSKTYGIFIGDVllsNGHDNLQdsfvaTFTTKLGDIS
  661-  831 (242.98/162.67)	FNDLLKTWVRDLFINgSISDPLMKSANVKD...LAVLipyifkQSIMSV......ELGSI.RDVstLIGGFEYFLQPFLIVGLIGIVFWLEHYLTTLKSEEIPTELQQSIFEMLNSVI..NPAALNdESKPLHVlilRLNAIGLIKTLKF...FRTQSQSNYGIYSSDV...QGDPKLE.....TLITCLENIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.61|      34|      65|     198|     234|       4
---------------------------------------------------------------------------
   54-   79 (37.91/17.63)	KDI...................YRKLADVFLSAL..............NCEGN..VLLVEY........
  198-  233 (56.62/39.46)	KLL...................YKKVADDFESKL..............NYENSEPNFPTDYahNTVSPS
  238-  298 (29.08/11.88)	KFMhsplttssrdigknstttaYQDV......KLiryyknlwlnskimNWSANERDFLIKY..NSIGAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10467 with Med5 domain of Kingdom Fungi
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