<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10453

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTTAVQDFKVFNGGGLQSNTSQKQELSRTSMTQRQDNKAVRFDPPEIPHVEFNQSPLSLIIRNLTVFTIKEIAQFFKTSAHQSQDAGTRKASFLQMIIYLRNQFLRLYVLIKWCKTIKKNNFNTMIDLLNWFRGSNMSVNNCIWALKNNLVSMANAKLPNPDLVTALEVLSLGRPNLPTHNLKLSGDEGSEDVSVIPAKLILKRIRDLNTLLSIRISLMELPDQFYQYKVRDGKLVITVEKEFEVQLSTVDLQSPLFFVDLKFLFNDHLPLNKHKLEKVINEALFKSSKPLFSLYSLLHKYVLSLQMYMIHVELLDLEINGKYSGGNLVHHYDAKKNMITLKYWLQSRLNGKCSAIIGVEGTSGNIILKWNRNGVKNEHSDVPTQYSCILNNLGNILNEITFNHSQMIKAELLSTGVFSEDEENPDFLLFHVPTTSVSVAPIQLKINLISGVFYVKNPSSLLQFYINQINSSSTTDELIHILGRLKLDKIILVLRNMFEKTGWSCNDVIKLNSSVTQDSAKGQKRILTRDLFIRLDDWPANWYLILSVVSSNSTCVIEQRIGKIKAIKGNWELRYLDSANATTSKLESMTYQKIVYLQKTILHRIVNHMIIDSLNELNISNKICSGDILRALPPYVSSTGVNNNLSIIAIELESFLEGSNALNHILESSMLLRIDYEKSDIKLFGKFKKDTKIIKYQCDELLIQFTNPGALSFYIFEEFTNLNNIVLYLTKFKQKLMQLVVLTDVIERLHNNFYSENFSIVALKPNEISFKYLRNSTDTHDCMIKIVTNDHNVENLDVKLSSSNPQYIVQPFIDDGHYDYHFIFNYLQFTSGFFGVLKEILSSYEHSNGYTTVSLQLHNLSEYELLYHNPETNTKITLIIELRNVSHNGTKKLQYYIHFSDDEHISTKSPAYPLVHQVRNTVFMIDNTALVNGSSVSLKKPKHPSAIKLSDGVSCDSPDIEGIIMEINDILKIDCM
Length976
PositionTail
OrganismLachancea fermentati (Zygosaccharomyces fermentati)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.09
Grand average of hydropathy-0.140
Instability index37.99
Isoelectric point8.06
Molecular weight111604.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10453
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.56|      42|      47|     882|     926|       1
---------------------------------------------------------------------------
  882-  926 (66.31/57.62)	LRNVSHNGTKKLQY..YIHFSDDehISTKSPAYP.LVHQVrNTVFMID
  930-  974 (62.25/42.20)	LVNGSSVSLKKPKHpsAIKLSDG..VSCDSPDIEgIIMEI.NDILKID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.20|      31|     173|     477|     518|       2
---------------------------------------------------------------------------
  468-  506 (44.98/52.92)	QINSSSTTDElihilgrLKLDKIILVlRNMFEK.TGWSCN
  510-  541 (51.22/29.19)	KLNSSVTQDS.......AKGQKRILT.RDLFIRlDDWPAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     715.24|     251|     483|      69|     395|       3
---------------------------------------------------------------------------
   69-  395 (344.24/442.23)	IKEIAQFFKTSAHQSQDAGTRKASFL..QMIIYLRnqflrlyvlikwcKTIKKNNFNTM.IDLLNWFrgsNMSvnnciwalknnlvsmaNaKLPNPDLVTALE..VLSLG.RPNLPTHNLKL.SGDEGSEDVSVIPAKLILKRI..............RDLNTllsIRISLMELpdqFYQYkVRDGKLVITVEKEFevqlstVDLQSPLFFVDlkfLFNDHLpLNKHKLEKVI....NEalFKSSKplFSLYSLLHKYVlSLQmYMIH.................VELLDLEI...NGKYSGGNLVH..HYDAKKNMITLKYwlqsrlngkcsaiigvegTSGNI.ILKWNRNGvkNEHSDVPTQYSCILNNLGN
  564-  862 (371.01/277.64)	IKAIKGNWELRYLDSANATTSKLESMtyQKIVYLQ.............KTILHRIVNHMiIDSLNEL...NIS................N.KICSGDILRALPpyVSSTGvNNNLSIIAIELeSFLEGSNALNHILESSMLLRIdyeksdiklfgkfkKDTKI...IKYQCDEL...LIQF.TNPGALSFYIFEEF......TNLNNIVLYLT...KFKQKL.MQLVVLTDVIerlhNN..FYSEN..FSIVALKPNEI.SFK.YLRNstdthdcmikivtndhnVENLDVKLsssNPQYIVQPFIDdgHYDYHFIFNYLQF..................TSGFFgVLKEILSS..YEHSNGYTTVSLQLHNLSE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10453 with Med14 domain of Kingdom Fungi
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