<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10451

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMERRELPYRLEELLTSFYRLETVERINYVQYVPSKSDAQWSIQAELALRKHNPRILASLFSRELWCFSINSDSMPSLELDQLGNAPAPEKTGYFTPDISKPNLPTAYAVFLKALRRMIHINLCLESKQQLVPFGNSCLFKANENASKVVHFEPQLFENGDLCMSICTKEMRLCSLDVNMINEPFLKKNAIYLAPSGIRAYLVSPEVNKCISPAPKNASVLLITLLVSHGIDLTEKKDLTWVKVTPNLDHLNGYTPSIAGYLDPPKATKTAIWPLELCFSQPSATLVNSDDSLSFEPNLQETFDFIDDFIQLKLTSAFKTPGSTSGGLGTGTVTGNNALSTGGIYGDHYPAFHKHTQSGSLSTLGIFNSQTASRQSPSIAFMNTTPVNNRSAPQSTETLNSGFLTTPNINQNVETANDEMSTIGSPHKMRDIPWTAESKGSINGDEISEPSNGGLSDVSTSQTCEGDSDLDTELFGNDNEEENEEAVNINEVNAEQHVKDITDDMFDIDDESDSSREKTAHLKEPSPFNIEESPFKRKYLDIPLDEMTLPTTPLYMDPGAPLPIETPRDRRKSVFAPLNFNPIIESNVDNKYKNGGKFSFDGGKIEESLKFDVSTANISSSEDEESGSSVDDFDVLSGGNNIGPSLEGNPPLTVFPSESQPQTTLDVAQLGVFKEPSPPQNFDNNGNVEKSARENHFDMWKYPRGDTTRSYSPSKGHSQPRSMKLGQVNIGSNDPDDLTKISSITPLLDQPRKSPAISSYFSDTNSEGAERLDSSENMSTESIATPESSNSLPFLLRHMPLFSIPGIFFHQNPSLPFNDNFTSVLNLLSEQIIFDKGLLGDLSCEPITYNNFIGCDSGIVKTTVQSIFSKFQRLNGGELIEEINYIRQPAVYVKKNDELIKIKGDAEPFSSHLNLKPYKGIKSFRCLFLTTDRKDDCLEFLSSVSQIYSRQELGFCELVKLTSADTPGLIYLINLEKDTLLLLSAQLVSYLSTNTFNTKSVPLVIFLPIRNQSLRDVVSTTLKFEFLQKEVKSKLPNVNIFLKVIPMNFISNPLTSVEDYYDLCVGIYNSIPPKNMKFTAIADEVPKRIEFRTNQQANGQTSHFDMYIHLAYARSIDRNWICAAWSNSSGSDNGVETWYIGNSTTAFEDACNQMWQTTSKCAANNYGRVCLVLTRFDSVLPDDELMHWRRLSSASRSLHLAVVCVGDSTKLSLYDEDRMYPSFKPLFEDDRLSKKIEISNLDNYEIVDAGSEVHGIIFQNPLQLANSQHRCAIITGALVRFKSNSGHDILDKLEINLLNCPHSDSTKLLKIILQEFRNLAVLNTWFGLSKSEFSFIPWHVLAVKKMIKTVVHLKVTEST
Length1358
PositionKinase
OrganismLachancea nothofagi CBS 11611
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.09
Grand average of hydropathy-0.360
Instability index46.40
Isoelectric point5.10
Molecular weight151558.00
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10451
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.37|      38|      99|      59|      96|       1
---------------------------------------------------------------------------
   59-   96 (71.31/44.57)	LFSRELWCFSINSDSMPSLELD.QLGNAPAPEKTG.YFTP
  155-  194 (62.06/37.79)	LFENGDLCMSICTKEMRLCSLDvNMINEPFLKKNAiYLAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     752.93|     166|     167|     643|     808|       2
---------------------------------------------------------------------------
  376-  555 (223.66/97.37)	PSIAFMNTTPV.NNRSAP.QST.ETLNSGFLT.TPNINQNV.E......TANDEMSTIGSPHKMRDIPW......TAESKGSINGDeiSEPSNGGLSDVStsqtcegdsdldtelFGNDNEEENEEA.VNINEVnaeqhvKDITDDMF..DIDDE....SDSSREKTAHLKEPSPFNIE..ESPFKRKYLDIP.LDEMTLPTTP.LYM
  557-  640 (48.11/15.88)	............PGAPLPiETPRDRRK.SVF.....APLNF.NpiiesNVDNKYKNGGKFSFDGGKIEESlkfDvSTANISSSEDE..ESGSSVDDFDVL...............SGGNN........................................................................................
  643-  808 (279.26/123.18)	PSLEGNPPLTVFPSESQP.QTTLDVAQLGVFK.EPSPPQNF.D.....NNGNVEKSARENHFDMWKYPRG...D.TTRSYSPSKGH..SQPRSMKLGQVN...............IGSNDPDDLTKI.SSITPL......LDQPRKSP..AISSY...FSDTNSEGAERLDSSENMSTESIATPESSNSLPFL.LRHMPLFSIPGIFF
  812-  970 (201.90/87.27)	PSLPFNDNFTSVLNLLSE.QIIFDKGLLGDLScEPITYNNFiG.....CDSGIVKTTVQSIFS..KFQRL...N.GGELIEEINYI..RQP......AVY...............VKKN..DELIKIkGDAEPF......SSHLNLKPykGIKSFrclFLTTD....RKDDCLEFLS..SVSQIYSRQELGFCeLVKLTSADTPGLIY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10451 with Med13 domain of Kingdom Fungi
Unable to open file!