<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10441

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDVKPVSEAEGVPLLLDPNLFGLFSKRTPADLDTTSDNKEQNEQQPATDHLKPHSSLVNNPFETYEKTPLDQLIPLIVRSRGQGFKFADLSEQLLLNEIEQEQERNGIETHVSDNDNDINKESEESLDQNGLPLKRSTPEATFEANDEHTMSLEKFQQCKRNTIQSLDLALNESSLALEFVSLMLSSVRPSAASASMSPYLKKNVPAGTLSGEKVLLNRPSREETLQKQVINKGWKLRSLEEARSLLKEVYLESTKTLEKERKHWSEISHFISNKDVVFKTRDKDTGERSLGFKYGYRDSGSSYKLDRGIAVLKHNALLRKLELVPIEENAKAVHINQKNREKFLRVRIFTKLQEEDDYILTGESDLDSLLLPEKDEDEEDDMRIQIKRLKFFIFEQELMNRILKESEQLFSYGVSIENENKVVIEFPTEKMEVEYVQLNDDILLNHQQDAPKTNDKRARLFLVMMRLLLVVMYKKQLKGNILSVQQSGAAATKNTRSSNASKLSEPLIIRPILGKIRHNSYLCLLKKIIKDSVLDSVLEKDLRISPKAKTAEDLSASKIFDDHISKLNMEIYAFDEILSVPETEIVVDLAKNGRLLLTLQSPNYCNAITTVKYVDSSENIHFNTRFSDFKELEEFLHFIVTEYVN
Length646
PositionHead
OrganismLachancea mirantina
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.07
Grand average of hydropathy-0.536
Instability index53.54
Isoelectric point5.43
Molecular weight74058.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10441
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.02|      52|      55|      54|     108|       1
---------------------------------------------------------------------------
   50-  106 (75.10/59.08)	HLkpHSSLVNNPFETYEKTPLDQ.LIPLiVRSRGQG.FKFADlsEQLLLNEIEQEQERN
  107-  162 (76.92/49.96)	GIetHVSDNDNDINKESEESLDQnGLPL.KRSTPEAtFEAND..EHTMSLEKFQQCKRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.39|      13|      15|     238|     250|       2
---------------------------------------------------------------------------
  238-  250 (20.35/11.82)	RSLEEARSLLKEV
  256-  268 (21.04/12.46)	KTLEKERKHWSEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.36|      56|     202|     298|     360|       5
---------------------------------------------------------------------------
  298-  360 (77.65/65.31)	RDSGSSyKLDRGIAV......LKHNALLRKLELVpIEENakavhINQKNREKFLRVRIFTKLQEE.......DDYI
  497-  565 (79.71/47.33)	RSSNAS.KLSEPLIIrpilgkIRHNSYLCLLKKI.IKDS.....VLDSVLEKDLRISPKAKTAEDlsaskifDDHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.58|      19|      37|     438|     456|       6
---------------------------------------------------------------------------
  438-  456 (33.70/26.50)	QLNDDILLNHQQDAPKTND
  477-  495 (30.88/23.63)	QLKGNILSVQQSGAAATKN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10441 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EIEQEQERNGIETHVSDNDNDINKESEESLDQNGLPLKRSTPEATFEANDEHTMS
2) KRTPADLDTTSDNKEQNEQQPATDHLKPHSSLVNNPFETY
98
26
152
65










Molecular Recognition Features






MoRF SequenceStartStop




1) SLGFKYGYRD
2) SPYLKK
290
198
299
203