<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10439

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMKNHIEGPVIARKKRRVRAHIMAGNSVSYPLENIATNFYKIGNIEKVNYAQLIQENSDSQWCIQAELILRKENPKALVALFSRDLWCFSLNDEPLPFPSHENGDEARPKLDKKGHFTPDVPKPNLPTPYAVFLKALRRMVYVNLCLNSKESLVPFGNLGIYSRGSWASRIISFEPHLIESGELCLSMDMKEIPFVKLDAGLLRDTFLTQSAVYLAPSGIRAFFATKDPKDAICAAPKNAKILLITLLLSYGIDLTRRSEITWVNLIASLDHLNGQTSKVSRYLETPKTYKKVVWPLELCYAQMCSGFKPKDEMIEGELEPDLDEVFEIIDDFVQLKLTSAFRTPGSAGTGTGTGTATGYNPLSTGAAYSDNTQLLHKHSNSIGPAPTSNINIPQSNSLKTTPNELGSNITPAPPPSSAPPSADDQFQSAFLNSPHLNGDQLDKKRFNYIKHPNSDNERSDAWLDKEKSNIEAHQSDSPAEQMEKLVKIPNSEYDNDKPSEEDDMGLLGDADDEELFGEHSDTDDIQKQDLKDITDDMFELAQDSATDSPSDSPRQGAFDHSKNLKRKYLDIPLEEMTLPTTPLYTDPGAPLPVETPKDRKKSVFAPLNFNPIIESNVDNKYRNGGKFSIDTRKSEEPLKFDVSTANISSSEDGASMSEEDEFGDLIEDRINSQSFDVGMISIPAYQGDLQDRPPEFARHDFSKEASFLPPSSSGLSPEKLMKDGQRDLWKSPRDAKNGEISIPPGNIPPPSEAAFDNCDYLKDGDGICEEGQDVQATEEEKTLLHQTNEAATSGPVATTNRNSDSEIGSQESSNTLPFLLRSVALNTIPRRFYDKCPTTSIEGVQSVLNLLTEQIVFDKGLLKMGGSEDSAHDVFKSCEEGFVQDSLKNIFGLFDRVYGDKIIDEIFYMKQPLVQVKKNSEVIKIKADSESFAQYLNLKPVQRFKCFKALFLTTSFKDDCTDFLSVVSQTYTAQELGFCELVKLTDEDIPGLIHLINFERDTLSLLSAQIVSYCSRSTRNTANVPLMLFLPLDSVDIFSIMYMTLKFNLIKVEVVSKLPKVELYLKLIPTKFIRSPLTSVNDYNDLCTGLYNSLPPLHIKFTVIAKSLPEKITFKTTQGNDSHSFSFKSFLHLAYARSVDKNWLCAAWTSSSGDENIVRTWYTGNSKSAFENSCNQMWQTTLKFAATKCGRICLVLTRLDNVLPDDELMNWRRLSSTSKNLHLAVVCVGESSNLTLLDEDKSYPSFKPIFRDIDTSISLDSNALDKYQIVKISNEVHGVIFQHPLQLLHSLHRCPIINGALVKFKPGEGDDFVEKLDVNLLNCPHSDSRNLLKSILEEFRNLAALSAWFGVSQREKEHIPWHILAVAKMMKFVVHIDVSNCDV
Length1383
PositionKinase
OrganismLachancea mirantina
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.08
Grand average of hydropathy-0.390
Instability index45.31
Isoelectric point5.22
Molecular weight154722.28
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10439
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     214.47|      38|      38|     688|     725|       1
---------------------------------------------------------------------------
  398-  439 (47.50/23.32)	.LKTTPNELgSNITPA.PPPSSAPPSaddqfQSAFLNSPHL.NGD
  529-  565 (41.15/19.13)	DLKDITDDM...FELA.QDSATDSPS.dsprQGAFDHSKNLK...
  688-  725 (60.47/31.89)	DLQDRPPEF.ARHDFS.KEASFLPPS.....SSGLSPEKLMKDGQ
  727-  765 (65.35/35.12)	DLWKSPRDA.KNGEISiPPGNIPPPS.....EAAFDNCDYLKDGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.91|      18|      33|     588|     610|       2
---------------------------------------------------------------------------
  588-  610 (28.61/25.69)	GAPLPVETPKDRKksvfaPLNFN
  624-  641 (31.30/16.66)	GGKFSIDTRKSEE.....PLKFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.85|      17|      38|     440|     456|       3
---------------------------------------------------------------------------
  440-  456 (32.59/18.72)	Q....LDKKRFNYIKHPNS..DN
  458-  478 (20.59/ 9.20)	RsdawLDKEKSNIEAHQSD..SP
  481-  495 (17.67/ 6.88)	Q....MEK....LVKIPNSeyDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.53|      18|      38|     143|     160|       4
---------------------------------------------------------------------------
  143-  160 (32.53/17.79)	NLCLNSKESLVPFGNL..GI
  182-  201 (28.00/14.37)	ELCLSMDMKEIPFVKLdaGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.76|      16|      39|    1066|    1082|       5
---------------------------------------------------------------------------
 1066- 1082 (23.34/17.37)	KLIPTKfIRSPLTSVND
 1106- 1121 (28.43/16.01)	KSLPEK.ITFKTTQGND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.56|      23|      33|     973|     995|      11
---------------------------------------------------------------------------
  973-  995 (38.72/26.10)	AQELGFCELVKLTDEDIPGLIHL
 1008- 1030 (38.84/26.21)	AQIVSYCSRSTRNTANVPLMLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.88|      16|     723|     124|     139|      12
---------------------------------------------------------------------------
  124-  139 (29.82/20.46)	NLPTPYAVFLKALRRM
  849-  864 (28.06/18.80)	NLLTEQIVFDKGLLKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.61|      11|     155|     499|     509|      13
---------------------------------------------------------------------------
  499-  509 (21.28/14.59)	SEEDDMG.LLGD
  657-  668 (16.32/ 9.18)	SEEDEFGdLIED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.14|      13|     721|     359|     376|      15
---------------------------------------------------------------------------
  359-  371 (23.42/20.06)	YNPLSTGAAYSDN
  377-  389 (23.72/ 7.46)	KHSNSIGPAPTSN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10439 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GICEEGQDVQATEEEKTLLHQTNEAATSGPVATTNRNSDSEIGSQE
2) LKFDVSTANISSSEDGASMSEEDEFGDLIED
3) SIPAYQGDLQDRPPEFARHDFSKEASFLPPSSSGLSPEKLMKDGQRDLWKSPRDAKNGEISIPPGNIPPPSEAAFD
4) TPGSAGTGTGTGTATGYNPLSTGAAYSDNTQLLHKHSNSIGPAPTSNINIPQSNSLKTTPNELGSNITPAPPPSSAPPSADDQFQSAFLNSPHLNGDQLDKKRFNYIKHPNSDNERSDAWLDKEKSNIEAHQSDSPAEQMEKLVKIPNSEYDNDKPSEEDDMGLLGDADDEELFGEHSDTDDIQKQDLKDITDDMFELAQDSATDSPSDSPRQGAFDHSKNLK
766
638
681
343
811
668
756
565










Molecular Recognition Features






MoRF SequenceStartStop




1) DDEELF
2) DEFGDLIEDRI
3) LKRKYLDIPLEE
511
660
564
516
670
575