Description | Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MVLQLSLVSAIDDESYDLCTSTLCNLSGNPPVLFSHFTAMLKPNPTFDIEQTNSKNQLIEQNRLKLCKEVPLDQLEPDGSKRDYEMLKNYQDDKLDGFNLQVVEDMLHGSTDLDRMDVDEAKSDDSWILSIADIPAAGSNRKVSTQSITENTILSSGGSSPSIIAFLSEFGYVPDYQFLTLGVKFNMNHSVYLELSKVWLIQGGESKQITKGGFLVKAFVNVTKGTDIKSINHGTNALLNLQKELSGYIDLTIPDRKSMDSRLENLSDI |
Length | 269 |
Position | Head |
Organism | Lachancea nothofagi CBS 11611 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.289 |
Instability index | 29.70 |
Isoelectric point | 4.66 |
Molecular weight | 29895.42 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP10438 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 38.96| 12| 19| 85| 96| 1 --------------------------------------------------------------------------- 85- 96 (21.56/13.29) EMLKNYQD.DKLD 105- 117 (17.40/ 9.49) DMLHGSTDlDRMD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 52.40| 15| 20| 198| 212| 2 --------------------------------------------------------------------------- 198- 212 (26.75/18.66) VWLIQGGESKQITKG 220- 234 (25.65/17.63) VNVTKGTDIKSINHG --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) RLENLSDI 2) YIDLTIP | 262 248 | 269 254 |
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