Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MVALDLNKMHDDLAGVEQQIGAIIESFVELGVSVYDFPGTSEAAQGMMTNLKRNVDRLGKLNKQSNDPDSQLNLFQIPIEVLQYIEDGRNPDVYTRDFVEAIRRSNQYQRAKMNGVKQLRDKLAHKIVEEFPDMEASVKDILNRTER |
Length | 147 |
Position | Middle |
Organism | Lachancea dasiensis CBS 10888 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.567 |
Instability index | 54.58 |
Isoelectric point | 5.08 |
Molecular weight | 16796.83 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi RNA polymerase II preinitiation complex assembly GO:0051123 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP10429 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 100.97| 32| 58| 6| 37| 1 --------------------------------------------------------------------------- 6- 35 (45.13/30.42) .........................LNKM...........HDDLAGVEQ..QIG.......AIIESFVELGVS..VY 36- 94 (30.59/18.63) DFpgtseaaqgmmtnlkrnvdrlgkLNKQ...........SNDPDSQLNlfQIP.......IEVLQYIEDGRNpdVY 97- 139 (25.25/14.30) DF...........................veairrsnqyqRAKMNGVKQ.....lrdklahKIVEEFPDMEAS..VK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) LKRNVDRLGKL 2) PDVYTRDFV 3) QLNLFQIPIEVLQYIE | 51 91 71 | 61 99 86 |
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