<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10421

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEQKDLPYRLEELLTNFYRLERVERINYVQYIPSKPEGQWSIQAELALRKRNSKVLVSLFSRELWCFSINSDPIPTLELDHLGNTPAPEKTGYFTPDISKPNLPTAYAVFLKALRRMMHISLCLESGQHLIPFGNSCLFRGESRSTKVVHCEPQLFENGDLCVSFSCKNMRLCNFDTKMIDESFLQKNAIYLAPSGIRAYLYSHELEKCVSPPPKNASVLLITLLVSHGIDLTKKKDLTWVRVIPNLDHLNGYTPSVSSYLDPPRATKTAIWPLELCFSQSSAPLSKSLRELSLQPDLQETFDLIDDFIQLKLTSAFKTPGSTTGALGSGTVTGMNALSTGGIYGDHYTAQPKNFQAGSLYNLNVFGNHNSRRSPGGPSANVTPVHNRSAPQSAENVTPGFLTTPNVNENVDGTGEEILISGTSYKRGENIWTEQNRVSENESESLSTNHAAASESSVDQDNAELDAELFGDDKDDEQLSSDEVNFPQQTKEITDDMFDMIDDSDTSREKTMQLKEPSPFSTDESPFKRKYLDIPLDEMTLPTTPLYMDPGAPLPIETPKERKKSVFAPLNFNPIIESNVDNKYKNGGKFSLDAGKNEDSLKFDISSAKMSSSEEEDLASSDEDLDDFAVNSNVGPALESNTQPTTFAIENQPPISSNDIQRIAFQDPSPLQSFENESGDEKGLREVHSEFWRYPKGASYDFSPSKAYSSHSNSVKPVQFNAESNGPDELSIIKNFTPLLDTVSKSPLANQILDDPAAKQAENKGKLKLDVIGATDSVSAPETSNSLPFLLRHMPLFSIPDIFFHNNPSLSATEGLSSVVNLLVEQIIFDRGLLGDLGSESVTYSAFMDCGDGIIKKCMQDSFSEFERLNGGQLIEEINYIPQPAVYVKKSDEIIKVKGDSDYFSSQLRLKPYKGIKNFRCLFLTTELKDDCLDFLSTMSQIYQSQELGFCELVRLTFADTPGLIYLINLEKDTLLLLSAQIVSYCSTNTQNILSVPLVLFLPISKKSLADVVLMTAKFEFLREEIVSKLPNVRLVLKLIPIDFLTDPMTSVKDYYDFSVGVYNSISPHNIKYTAIADELPKKVEFRTNKELNGQTTHFDVYFHLAYARSIDRNWVSAAWSSSSGNESGAKTWYIGNSTTAFEDVCNQMWQITSACLTNNYGRACLILTRFDSVLPDDELMHWRRLSSTSRNMHLAVVCVGDNTKLSLFDEDRMYPSFKPIFEDDRLSQNVDVTNLDNYEIVDIGREIHGIIFQRPLQLSNSQHRCAINTGALIRFKGSSSRNVVDKFEVSLLNCPHTDSTKLLRIILQEFRNLSTLNSWFGVSKSRSSFVPWHVLAVKKMINAIVHLKVTDDT
Length1354
PositionKinase
OrganismLachancea dasiensis CBS 10888
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.09
Grand average of hydropathy-0.351
Instability index42.60
Isoelectric point5.08
Molecular weight151614.22
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10421
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.90|      10|      14|     648|     657|       1
---------------------------------------------------------------------------
  648-  657 (17.63/ 7.61)	AIENQPPISS
  664-  673 (18.26/ 8.14)	AFQDPSPLQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.63|      34|     448|      67|     104|       2
---------------------------------------------------------------------------
   67-  104 (57.57/54.81)	FSINSDPIPTLELDhlgnTPAPEKTGYFTPDISKPNLP
  520-  553 (64.05/48.21)	FSTDESPFKRKYLD....IPLDEMTLPTTPLYMDPGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.22|      26|     448|     859|     902|       4
---------------------------------------------------------------------------
   10-   36 (41.17/19.59)	LEELLTNFYRLERVERINYVQYIPsKP
  859-  884 (47.05/66.07)	MQDSFSEFERLNGGQLIEEINYIP.QP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.28|      17|     194|     299|     315|       7
---------------------------------------------------------------------------
  299-  315 (30.59/17.07)	QETFDLIDD.......FIQLKLTS
  495-  518 (26.69/14.03)	DDMFDMIDDsdtsrekTMQLKEPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     279.39|      89|     782|     126|     225|      13
---------------------------------------------------------------------------
  126-  225 (143.01/114.91)	SGQHLIPFGN....SCLFRGESRSTKVVH...CEPQLFENGDLcvSFsCKNMRLCNFDTK.MIDESFLQKNAIYLAPSGIRAYlyshelekCVSPPPKNASVLLITLL
  906- 1002 (136.38/85.02)	SQLRLKPYKGiknfRCLFLTTELKDDCLDflsTMSQIYQSQEL..GF.CELVRLTFADTPgLIYLINLEKDTLLLLSAQIVSY........CSTNTQNILSVPLVLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.02|      40|     176|     569|     613|      14
---------------------------------------------------------------------------
  569-  613 (59.20/45.48)	PLNfNPIIESNVDNKYKNGGKFSLDAGKNEDSlkfdISSAKMSSS
  747-  786 (66.82/37.40)	PLA.NQILDDPAAKQAENKGKLKLDVIGATDS....VSAPETSNS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10421 with Med13 domain of Kingdom Fungi
Unable to open file!