<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10417

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMSKNASNEITALYPPPPPYIEHFTAENLHKLQELEKAGRGAESLDDGLKYLVPPDVPTEGHYRAFGSVWQVKDELPDLKSMGMTQLYLPKADTDGSKSSYQDKIQELHKLLQSLLLNFLELTGILSVNPEQFPAKVDHIQTILVNFHHLLNEYRPHQSRESLIMLLEEQLEYKRKEISKIEQVCQEVKEKLANLIDGGDKYEDSTLSQSKRPDAGDVEMADAVDVTEEHPTDGAQEDGNHA
Length241
PositionMiddle
OrganismLachancea dasiensis CBS 10888
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.06
Grand average of hydropathy-0.669
Instability index49.17
Isoelectric point4.85
Molecular weight27217.18
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10417
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.28|      11|      26|     111|     121|       1
---------------------------------------------------------------------------
  111-  121 (17.99/11.45)	LQSLLLNFLEL
  139-  149 (20.28/13.66)	IQTILVNFHHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.75|       9|      34|      50|      60|       3
---------------------------------------------------------------------------
   50-   60 (13.78/15.69)	YLvpPDVPTEG
   87-   95 (17.97/10.96)	YL..PKADTDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.10|      21|      26|     159|     179|       4
---------------------------------------------------------------------------
  159-  179 (32.61/23.44)	RESLIMLLEEQLEYKRKEISK
  188-  208 (33.48/24.26)	KEKLANLIDGGDKYEDSTLSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10417 with Med7 domain of Kingdom Fungi
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