<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10416

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMIITDSAHHEAVSWSNSGLIGYVDTESSYANLCITLMETVNGTNWRLRPSKKYAIYPSMLETSSAVSSSNLNSGNGAPQRSFNNLRSVHWDNSSSHTGEQLAVCDEIGNLTVMVAGLTMEGPSTLDKLVVVFQDNVYKIHNQMAPLEESSAKSKVVRKQVKKESHATIIEFMWVGTQTSHFALLGARRDATTSSYKSQVQQFQPCGLFHPTSIKSACLALRRGGQIDFWYQFSNSKDHKKISLQLNTFQESRSKQFDWIQIGKFAQMDDEQTIVLGAYSKLSKKISFYKLSVNWNNTTQNAVSDPKLQLQHLIEINPENLSAKGEIMQLANFEILPPTYDKTSSVELILSYDITGFSRSVVKRYKLVKSTPSPEICSAFGVLSTDGQFPPLYDYSFSEQETIDFESGIHSIERHGLDTTLLFRMKNGQTKVCDRRSWTWEQTWHSEKSSPKEFNGDVLSSPFCTGIHFAITSPPSANEWSLVSPAMGGVLSKSKTRTGLRFDPIVAPVTDALHDDFHIASAFAYAFVCANHQQSSGEDLSIAIKTHLLKIAQYSEIRAEKFLKVVICTIYQLFGLSPDASKELKDKMIMSRPIQKAILLQSELGCSFTNSNVYNMSRTAMSLRNILFAFNGVSRNIQVLIHHSATMNFQQPNGKLFQFAFSKQDLIYSLIPCAKWFVKLVTFLTQQMIVLVNSPNNKENTLVLGIFSSKMTRQLLLSVLSEIKKVIHLVTKFPETSFPILNESSIYLRKVLGDSPVNFEKFETFLADVNNKFTSLGEQPSSGISGTSGTSGTSGTSPHDSYLIIEGNIPSELSHLKEFLLSYSNTAVLSHIKPADVYFSDTRGLRIFASEIFSKPVFKLLQPLEKGLVVSSEVLSHEIPSSSFSVVESDDISKEPLKTGKYKLKRCCRCGTVTRAGYTVTKDNTIVPTSISPKRWTSLYLKICICSGLLYELEDEVHEREM
Length961
PositionTail
OrganismLachancea nothofagi CBS 11611
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.09
Grand average of hydropathy-0.197
Instability index46.30
Isoelectric point8.37
Molecular weight107417.29
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10416
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.35|      37|      40|     590|     629|       1
---------------------------------------------------------------------------
  590-  629 (54.24/36.59)	SRPIQkaILLQSELGCSFTNSNvYNMSRTAMSLRNILFAF
  633-  669 (64.11/34.12)	SRNIQ..VLIHHSATMNFQQPN.GKLFQFAFSKQDLIYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.84|      22|      43|     149|     170|       2
---------------------------------------------------------------------------
  149-  170 (35.24/18.69)	SSAKSKVVRKQVKKESHATIIE
  193-  214 (41.60/23.15)	SSYKSQVQQFQPCGLFHPTSIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.11|      16|      39|     787|     802|       3
---------------------------------------------------------------------------
  787-  802 (29.62/16.00)	SGTSGTSGTSPHDSYL
  823-  838 (28.50/15.16)	SNTAVLSHIKPADVYF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.09|      15|      39|     891|     907|       4
---------------------------------------------------------------------------
  891-  907 (24.60/21.94)	ISkePLKTGKYKLKRC.C
  930-  945 (26.49/16.37)	IS..PKRWTSLYLKICiC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.02|      32|      47|     241|     287|       6
---------------------------------------------------------------------------
  241-  277 (45.00/52.22)	ISLQL.NTFQESRSKqfDWIQIGKFAQMDDEQtivLGA
  290-  322 (50.02/23.50)	LSVNWnNTTQNAVSD..PKLQLQHLIEINPEN...LSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.42|      23|      41|      82|     106|       8
---------------------------------------------------------------------------
   82-  106 (37.78/32.87)	FNNLRSVHWDNSSS.HtgEQLAVCDE
  125-  148 (35.64/23.41)	LDKLVVVFQDNVYKiH..NQMAPLEE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10416 with Med16 domain of Kingdom Fungi
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