Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MPQPEFIQERLKSLNTIDDLLLATLLHASQAVGTIEELKRGNENMKPQFENHARSFYNSLEEATVGLRREIKHLDENVGTRLLPINVNKRATGQDNDKIREQFDKLENELKESS |
Length | 114 |
Position | Head |
Organism | Lachancea nothofagi CBS 11611 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.832 |
Instability index | 51.11 |
Isoelectric point | 5.41 |
Molecular weight | 13128.58 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP10405 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 45.38| 13| 31| 32| 44| 2 --------------------------------------------------------------------------- 32- 44 (23.46/14.28) VGTIEELKRGNEN 65- 77 (21.92/12.98) VGLRREIKHLDEN --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FENHARSFYN 2) GLRREIKHLDENVGTRLLPINVNKRAT 3) IEELKR 4) QDNDKIREQFDKLENELKESS | 49 66 35 94 | 58 92 40 114 |
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