<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10395

Description LADA_0D05798g1_1
SequenceMYGAQSQGSNFYHHPQGSSQSTWQQQMSDSKGATSNSGKPLLMANNSIFSIGPYKRRKDANRVSVVEKYEIIGYIAAGTYGKVYKARKKSSGRDSPPSSLTDNESSVPVSLNQPLDGNDALDINSINKSTRVPDSSAPSVPNNQPQGTNADHKSQPSAQIPHGSNVSNSIILGSPTKKLPSLYAIKKFKTEREGVEQLHYTGISQSACREMSLCRELRNKHLTHLVEIFLEHKSIYMVSEFAEHDLLQIIHFHSHPEKRLIPPKMLKSIVWQILDGVSYLHQNWILHRDLKPANIMVTVDGCVKIGDLGLARKFHNMVQTLYTGDKVVVTIWYRAPELLLGARHYTPAIDLWAVGCIFAELIGLRPIFKGEEAKMDSKKSVPFQGNQLQRILEVLGSPNENSWPDIHKYPECEHLSKFPRYRDNLPVWYHSAGGRNKDALDLLYQLLRYDPITRVDAVDALEHSYFTNDAPTVSENVFEGLNYNYPPRRIHTNDNDIMNVTNPNAKSTASHTQSMASKNVGNSSLGGLGVNKRILAAAAAAAAAVSGNNSSTRAGSSTAANGPLRKKRK
Length569
PositionKinase
OrganismLachancea dasiensis CBS 10888
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.07
Grand average of hydropathy-0.515
Instability index46.05
Isoelectric point9.33
Molecular weight63046.53
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IEA:EnsemblFungi

GO - Biological Process
negative regulation of filamentous growth	GO:0060258	IEA:EnsemblFungi
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
nuclear-transcribed mRNA catabolic process, non-stop decay	GO:0070481	IEA:EnsemblFungi
phosphorylation of RNA polymerase II C-terminal domain	GO:0070816	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi
protein destabilization	GO:0031648	IEA:EnsemblFungi
response to oxidative stress	GO:0006979	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP10395
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.41|      26|      28|      92|     119|       1
---------------------------------------------------------------------------
   92-  118 (42.37/31.68)	GRdSPPSSLTDNESSVP.VSLNQPLDGN
  123-  149 (43.04/22.29)	IN.SINKSTRVPDSSAPsVPNNQPQGTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.23|      19|      22|     482|     502|       2
---------------------------------------------------------------------------
  484-  502 (35.60/24.54)	NYPPRRIHTNDNDIMNVTN
  504-  522 (31.63/14.27)	NAKSTASHTQSMASKNVGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.47|      20|      22|     248|     267|       4
---------------------------------------------------------------------------
  248-  267 (37.19/23.63)	QIIHFHSHPEKRLIPPKMLK
  272-  291 (36.28/22.88)	QILDGVSYLHQNWILHRDLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.55|      20|      29|     295|     314|       8
---------------------------------------------------------------------------
  295-  314 (34.05/21.76)	IMVTVDGCVKIGDLGL.ARKF
  327-  345 (25.13/14.37)	VVVTI..WYRAPELLLgARHY
  349-  368 (33.37/21.20)	IDLWAVGCIFAELIGL.RPIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.56|      18|     228|     171|     188|       9
---------------------------------------------------------------------------
  171-  188 (32.21/21.72)	ILGSPTK.......KLPSLYAIKKF
  394-  418 (28.35/18.23)	VLGSPNEnswpdihKYPECEHLSKF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10395 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQSQGSNFYHHPQGSSQSTWQQQMSDSKGATSNSGK
2) KARKKSSGRDSPPSSLTDNESSVPVSLNQPLDGNDALDINSINKSTRVPDSSAPSVPNNQPQGTNADHKSQPSAQIPHGSNVS
3) RIHTNDNDIMNVTNPNAKSTASHTQSMASKNVGN
4
85
489
39
167
522










Molecular Recognition Features






MoRF SequenceStartStop




1) FSIGPYKRRKD
2) RILAAAAAAAAAV
3) TAANGPLRKKRK
4) VVEKYEIIGYIAAGTYGKVYKARKK
49
533
558
65
59
545
569
89