<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10390

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTTAVEMLQNNGLASPERHNSTVGNGLKSSEKLGNNIHTGTNKDMDNDSQHYGNSSVSKAPELPHVEVNQLPIALLIRNLTVFSVKELVQFLKTSVHEGQDTSVKKTSFLQLVIFLRNQFLKIYVLVKWCRTIKNNNFNTMIDLLNWFRGSNMAVNNCIWALKASLAGMLNAKLPNPDLVTALEVLSLGRPNLPTHSFSLSGEEESEKGPKGFSVPSKLILKKLRDMNIIMSVKVSLMELPDQFKQYTVRDGRLVIHVENEFEVQLSTTDQRSPLFFVDLKLLFNELLPLNKYKLEKVINEVLFKSPRPLFALYRLLHNYVLSVQMYILHAELLDLESNSKYSGGNLKHHYDSRKNGITLKYWLHSRLKGKCNAIIGVDKESGNITLKWNIEDLPEGNPLVPVRYSNVLNNLGNILDEIMFNHSQIIKSQLLSTEVLHEEEDISDALLFHVPSTPASVIPIQIKINPISGIFYAKNPSGLLTYYINQINKTTTTDDFVKVLNRLKLDKTISILKNMFEKVGWVCNNVIKLNAPISIESTGTQKMLSRDLYIRLQNWPANWYLILSVISSNASCALEKRIGKITASNGNWELKYLDTKNVATLKLESMTYQKVIHLKKTSLHSIIDHMIIDSLNGLHMRNKICAGDSLDAVPEYIFQDNSSNQTSVLSIELESFLGGPNALNNLLEKTMFLRIDYQENKIKLFGKFKHNSKMICNQYNEALMQFIDKDSLSFFMTETFIDLNNIVQHFNPFKQKLMQIVTLTDVIERLHNFYSENFSIVALKPNEISFKYLKHSNDEYDCLIHIQTTDHSVENLDVKLSPSNPQYIIQPFIESSKQDYKFVFNYLQFTSGFFGVVESILSTAGRNSSQASNGYSTLALQLHNLSEYELIYYNAEVNSKITLMIELRNVFLNGSQRLRYYVHFADDEHISSKSPAYPLVHRVRNTVFMVDNSSLVNSDTISSLGSPKKPKIASAIRLTDGICCDATDIELVIKEINSILRVNSI
Length1002
PositionTail
OrganismLachancea dasiensis CBS 10888
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.09
Grand average of hydropathy-0.176
Instability index35.74
Isoelectric point8.23
Molecular weight113938.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
RNA polymerase II repressing transcription factor binding	GO:0001103	IEA:EnsemblFungi
TFIIB-class transcription factor binding	GO:0001093	IEA:EnsemblFungi
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10390
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     154.44|      39|     234|     343|     382|       1
---------------------------------------------------------------------------
  343-  382 (66.49/47.87)	SGGNLKHHYDSRKNGITLKYW......LHSRLKGKcNAIIGVDKES
  546-  579 (29.45/14.58)	..........SRDLYIRLQNWpanwylILSVISS..NASCALEKRI
  585-  619 (58.50/36.26)	SNGNWELKYLDTKNVATLK........LESMTYQK...VIHLKKTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.14|      48|      63|     177|     228|       2
---------------------------------------------------------------------------
  177-  228 (67.26/57.38)	PDLVTALEVLSlGRpnLPTH...SFSLSGEEESEKGPKgFSVPSKLILKKLRDMN
  241-  291 (77.88/49.21)	PDQFKQYTVRD.GR..LVIHvenEFEVQLSTTDQRSPL.FFVDLKLLFNELLPLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.06|      34|     233|     647|     680|       4
---------------------------------------------------------------------------
  647-  680 (58.83/37.72)	LDAVPEY..IFQDNSSNQTSVLSIELES.FLGGPNAL
  879-  915 (50.23/31.11)	LHNLSEYelIYYNAEVNSKITLMIELRNvFLNGSQRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.02|      11|      31|     714|     724|       9
---------------------------------------------------------------------------
  714-  724 (20.10/13.50)	NQYNEALMQFI
  748-  758 (19.92/13.30)	NPFKQKLMQIV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10390 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVEMLQNNGLASPERHNSTVGNGLKSSEKLGNNIHTGTNKDMDNDSQHYGNSSVSK
4
59










Molecular Recognition Features






MoRF SequenceStartStop




NANANA