<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10384

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMSIPEIVNNDLVSWSKSGLIGYVDTESTDANLCITLLETVNGTNWRLRPSKRYAIHPHIAESGSAGSSSSLSNGNIGSGTSKTFNNISSIYWNNSAGNNGELLAICDEAGNLSVVAAGQTAAGAGTLDNLAVLFQDNGYKIHNQLAPLLPVNDGSKISRKLSKKETHTAIIKFMWLGSSSPSFSLLNARRDMSKSIIKSQVQQFKPLGIFYPTSVKSACLGLRRGGQLDFWYQFSNSKDYKKISLQLNNTQEHRTKQFDWIQTAQFAHTDEDQALIVGAYSKISKKVSFFKLSVNWNITTQNITADPELRLEQILEISPKDMTTKGEVLELQSFEMLSAFERSPDVEVVLCYDVIGMSRSILKRYRIIKSAPSLELCSILGSPNLNSQSLPLCEYVFTEVDTLRMDANVYSLELHGHETTILTRLTNGHTKIYDRRTWKVENSLAIENSSEILTSPFCTGVVFPKTLPSSALRWSCVSPSLGGILSKVRNKENIRFDPIEAPIKELAEADVPIALAFAYAFVCSNHLQTSSEDLTIAIKTHLLKISEISEARSEKFLKILISAIYQLFGVTPEASKELKDKLVMSRSIQRAMLLQTELSCSFTNNNIYNMARTALSLRNILFAFNGVSRNIQVLIHHSATMNFQQPNGKLFQFAFSKQDLIYSLIPCAKWFVRLLTFLTQQMIVLVNSPNDKENTLVLGICSSKITRQLLLSILTEIKKVIHLVTKFPETSFPILNESSIYLRKVLGDSPVNFEKFETFLADVNNKFSSLGESPSLGNNAKDSYLMLEGDVSPEVSQLKEFLLSYSNTAVLSHIKPADVYFSDTRGLRIFSSDIFPESLCKLLQPLKNGLVLGPDVLSEDTTSLSLCVIESDDISKEPIISGKHKLKRCCRCGAVTRAGYPVTKDSTIVPTSVTTKRWTSLYLKICFCSGLLYEFDP
Length937
PositionTail
OrganismLachancea dasiensis CBS 10888
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Lachancea.
Aromaticity0.08
Grand average of hydropathy-0.079
Instability index46.87
Isoelectric point8.42
Molecular weight104209.40
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
RNA polymerase II activating transcription factor binding	GO:0001102	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
regulation of establishment of protein localization to chromosome	GO:0070202	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10384
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.22|      22|      28|      50|      76|       1
---------------------------------------------------------------------------
   50-   76 (33.74/27.91)	SKRYAIHPHIAESGSAGsssslSNGNI
   81-  102 (40.48/22.57)	SKTFNNISSIYWNNSAG.....NNGEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.22|      10|      28|     223|     233|       2
---------------------------------------------------------------------------
  223-  233 (16.97/18.02)	RRGGQLDfWYQ
  253-  262 (21.26/15.34)	HRTKQFD.WIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.89|      16|      19|     646|     661|       6
---------------------------------------------------------------------------
  646-  661 (29.13/21.72)	PNGKLF..QFAFSKQDLI
  666-  683 (26.76/19.28)	PCAKWFvrLLTFLTQQMI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.90|      16|      16|     796|     811|       7
---------------------------------------------------------------------------
  796-  811 (25.55/17.25)	SQLKEFLLSYSNTAVL
  812-  827 (28.35/20.02)	SHIKPADVYFSDTRGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.02|      42|     292|     441|     482|       8
---------------------------------------------------------------------------
  441-  482 (76.11/51.64)	ENSLAIENSSEILTSPFC..TGVVFPK...TLPSSALRWSCV..SPSLG
  729-  777 (57.91/37.30)	ETSFPILNESSIYLRKVLgdSPVNFEKfetFLADVNNKFSSLgeSPSLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.27|      23|      28|     159|     181|       9
---------------------------------------------------------------------------
  159-  181 (40.39/22.51)	RKLSKKETHTAIIKFMWLGSSSP
  190-  212 (40.89/22.86)	RDMSKSIIKSQVQQFKPLGIFYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.40|      14|      19|     829|     842|      11
---------------------------------------------------------------------------
  829-  842 (24.20/14.57)	IFSSDIFPESLCKL
  851-  864 (22.20/12.75)	VLGPDVLSEDTTSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10384 with Med16 domain of Kingdom Fungi
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