<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10374

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDKIIDARFERVEKALASLIESVSKYHPHAKQALDLHEADHDLAKGLDEVQIHQNNNLRLQQLRATTASLDTQIRETLSSLATTRKDITTTQITVHHDGPNYPVRYDELLNYARRISKTTLPPAALTNGGLTTGGGSPGPDPNASMTTNPNTPGANGLQSQPVSAAPTPSQGQTPGPSGAANGSPVGGLQDLLPGTQQTTATSGATSLPDGLRNHLNPHFNATFVPWPNEFQIRSGAMAVYQDLSDKGVDPRGYDPQQIAETKRKEEEDRKVREEQEKAEVERKNREYQEKMEKIRREQQEAYRRDSVAAGAVVGASSAGKSKQFQFTSLMDDDDDDE
Length338
PositionMiddle
OrganismColletotrichum orchidophilum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum.
Aromaticity0.04
Grand average of hydropathy-0.883
Instability index44.04
Isoelectric point5.46
Molecular weight36931.17
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364141

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10374
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.74|      18|      20|     260|     279|       1
---------------------------------------------------------------------------
  261-  278 (29.80/22.73)	ETKRK....EEEDRKVREEQEK
  280-  301 (24.94/17.15)	EVERKnreyQEKMEKIRREQQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.29|      20|      20|     144|     163|       2
---------------------------------------------------------------------------
  117-  136 (18.43/ 7.21)	.SKTTLPPAALTNgG.LTTGGG
  144-  163 (37.70/23.02)	ASMTTNPNTPGAN.G.LQSQPV
  166-  186 (27.17/14.38)	APTPSQGQTPGPS.GaANGSPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.82|      28|      31|     192|     219|       3
---------------------------------------------------------------------------
  192-  219 (48.43/25.94)	LLPGTQQTTATSGATSLPDGLRNH.LNPH
  224-  252 (46.39/24.61)	FVPWPNEFQIRSGAMAVYQDLSDKgVDPR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10374 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AKGLDEVQIHQNNNLRLQQLRATTASLDTQIRETLSSLATTRKDITTTQITVHHDGPNYPVRYDEL
2) SGAMAVYQDLSDKGVDPRGYDPQQIAETKRKEEEDRKVREEQEKAEVERKNREYQEKMEKIRREQQEAYRRDSVAAGAVVGASSAGKSKQFQFTSLMDDDDDDE
3) YARRISKTTLPPAALTNGGLTTGGGSPGPDPNASMTTNPNTPGANGLQSQPVSAAPTPSQGQTPGPSGAANGSPVGGLQDLLPGTQQTTATSGATSLPDGLRNHLNPHFNATFVPWPN
44
235
112
109
338
229










Molecular Recognition Features






MoRF SequenceStartStop




1) KQFQFTSLMDD
323
333