<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10373

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGGLNGTHPNHDRNLKVNGINGGAMEGQPNKGKAPADTPASGSMANGLSGGNVQHDSQGKQQSQVSTGLTLQQKPRMNDLPEEIVHITQGYIPLSTIVSRLAQHTHEELQKTIMDMAAIKWAPPAVNGNTPHGSDAPDDMSEGNKRRKMLMLKFAQDAHSKWVKALVITDWSKNAEAVSKLIDIKAHIDSKRMLYDYSQDLLIDLKLSLIGARLPNPDLKTALQVLTTGEASWVPEPGYIPSPPLTAEEQLKWIDDLNTMLSLRLNLDDYDKIPHQFKNYTIQSGRVTFIVKGEFEVDLTIADEDFNKQFWFIDFRFAFSPSSTKLSDALVSFLEGQVNEILGKEGLEGCYRFLHEFVLTHKISELRRQAIELSRSTWTGTLMVEPLNRALALQYWTTRYGPNGPKSWVMIAVNSARKTNGQTNSKHSSRLVARWYRDNKEVKDLFLPFDVDNLCAENLLKTAVARHVEHILSSIHTKLLSYPRFVNRESSLNMTISQTEPMESSLSMQLGSRDNVTLIIQPVTGFAAIKPHTKYSLTGESRLNYGGKDPAEVGVTCLENIRWGYVIEECQRRGRSVGWKTCKSPLGGEDIKQIVRTREAFQTIFLQRQSLDQSWFVMVSLSLSGDEWWLLDIDRSTPTRPIKFRTKMSLTRGQPDLDDSFWSNLTLFVTGIISHATDLEHLHRGKVQYLTKESTNYALPQQVRLPSLLIKLSQILRSPETGAQDGSKDVSRQSGKQDSSWAQDQVEVKFKGLQTRPTIAQGQDGKGSSAVDTIENAELNTVVDAIVRVKDKAKFALLRGRIDRDVSFSPRKGEFIFRIRQSVGQPILETLTAHVKSIDRLVGFLEAMSKARGSLKCERVGLRQVVFTYGDVAMPGESDQAQKPRRWRVSLDLVKSDIRMSLEKGNPHGRVLDLLTALVNTQDGLKALIFYMPILLPVLRSLESIESKWEPLETTNQGRVEVFTRSVDWIALRYTLPSPTGQSRVLVLEVRSKMRRNEMWWNFTRATQGSVAADEEFNKILRGIWESHGDGWRGLRSGAASRPGLSTMELLTKLDDAVRAYAVTGDVGNAPSTEGQPTQSSGTISTNQSFGTQPKSVSQGNKKTGGGSKQAPLVLD
Length1118
PositionTail
OrganismColletotrichum orchidophilum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum.
Aromaticity0.07
Grand average of hydropathy-0.436
Instability index43.41
Isoelectric point9.05
Molecular weight124902.53
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10373
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.53|      13|      18|       3|      15|       1
---------------------------------------------------------------------------
    3-   15 (27.86/16.12)	NGG.LNGTHPNHDR
   23-   35 (19.26/ 8.84)	NGGaMEG.QPNKGK
   48-   58 (16.41/ 6.43)	N.G.LSGGNVQHD.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.36|      45|     153|     474|     547|       3
---------------------------------------------------------------------------
  501-  547 (71.83/88.69)	TEPME..SSLSMQLGSRD.......NVTL....IIQPVTGFAAI.KPHTKYsLTGESrLNY
  641-  699 (58.53/23.99)	TRPIKfrTKMSLTRGQPDlddsfwsNLTLfvtgIISHATDLEHLhRGKVQY.LTKES.TNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.70|      18|      38|     220|     237|       4
---------------------------------------------------------------------------
  220-  237 (27.70/16.08)	DLKTALQV.LTTGEASWVP
  240-  257 (28.09/16.42)	GYIPSPPL.TAEEQLKWID
  258-  276 (23.91/12.88)	DLNTMLSLrLNLDDYDKIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.94|      30|     156|     801|     886|       6
---------------------------------------------------------------------------
  330-  363 (44.82/ 6.23)	DALVSFLEGQVNeilGKEGLEgCYRF.LHEFVLTH
  841-  871 (48.13/31.25)	DRLVGFLEAMSK...ARGSLK.CERVgLRQVVFTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.66|      21|      40|     703|     728|       8
---------------------------------------------------------------------------
  703-  728 (29.58/24.59)	QQVRlpsllIKLSQILRSPETG.AQDG
  746-  767 (32.07/15.96)	DQVE.....VKFKGLQTRPTIAqGQDG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10373 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVTGDVGNAPSTEGQPTQSSGTISTNQSFGTQPKSVSQGNKKTGGGSKQAPLVLD
2) MENGGLNGTHPNHDRNLKVNGINGGAMEGQPNKGKAPADTPASGSMANGLSGGNVQHDSQGKQQSQVSTGLTLQQKPRMNDLPEEIV
1064
1
1118
87










Molecular Recognition Features






MoRF SequenceStartStop




NANANA