<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10370

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTSEYDTNTLLNNNISTIIYRVYEPSPEQASSFPSAAADVESELRTLGRIVYYDANRRVLWYFHVPSKDAESADNTHGVLDSNVSVAGATLLMVDEGSFEPISLFKGRAQGQQAANTPTSSSSSNSALDLSLRNPQMGNSGPPSSSDPDSKPPSAGALDSKGAGSVPIKEAYEQFITAVLSTTSASFCNRVSAIPLNHRTVLLPSKVTRDGQTERAQDTESAVVGTFRIYLTTTGALVMSLCLSCCEGLLSVNEPSSPSQLALGSQILAAPFGVLANYQGFVGGGLSYPELGLGQTPDAQFWRSADARSSQWRDTCVKILQSRGLSPALLQSCPWIALQMLRRKPGDTKMEGKLTPLPSAVATISWPAVLCFRKKSVMLARSNGLGDSVLLAQDETSDFLNDARTWFQLGGDRDDRVAKRKKEREAAAKQEASAAAPTQQPNGNSPLGLRRASNAAAAGAMYPTPPDGVQNPLGITPSMDGTTSSPGAPGITMAVVDIDTTMTDATAHDPTTMNSTQHHDSYSDAWHSNEHTNEHTNEHSNENGKNRTDAFLGGDNDNLFGDMGPDIFGDADITDADFNFFDEGGDDNLDLSGLPDLGMSDVPSMPAVLPVSMPEPAKQVIPAVEDTKPEPSPPIFAKPELKHARSTLMEEGKQRSNADRAGGLKRESSPFDPDTVYKRVRASLADVHSTPHRTPARKGSIFDSVDFDPILPLVNKKYEQGGRFDCKPTHHGLPQESNKQSPHQGPPTTDYLRRHGKGRKTLKQPEHTNALIRTITGNLENSSLITSPDKGDDLASDADDISLVSDQDDSSTSEDEPTSPFKSSIRRLNLDDDVASHVTSLRDIESVEDSDPTLALDLPKLAKAEASEILITRYFEDAESLPIHLSLPDEDTVTTAQIVTEQAVTGNLRIRDAHANTLNTAIIPETRRQLSSLGRTALQALREVIPACLGEFNTCNFRSVVEIPDVPLLGPPNRLHPRPVNPRDNAEPPKPNNLFQIPAPHMELRRAEARLSVLPASVQFWESLGLGPAQGTKDVNVVCVFPHWDGMSDVAAAFLDRMRNVYELLKLGSFERLATSSNVTDGLVPFEADKIATSPGNVSPHIVAGLGDRMEALNQGLISANASEKNFVVYFVYPPDHPGSIVEACTAFQQLFEMHRRSLTEKRQTPVNELVLQLVPLDFLTSSTGIVEPTPSDAIKLAIETYDRCTLFGGPMPSPAIMLEQSLPRGIDFKLSNASSSSLMHENTCIHIAYAQSIDERWITAAWTDNRGCQQMTASYNLGRRGKALSTSLNEVCHVIWETTHDLISKWKVHWRVIISKCGFMDAQEVGFWQGLAQTESVATVSLTLISVDTNPSMQLVPPAIKVPATTSSAFYTTPVSTPQASIVSPEQSGTPVTPMKENPTSAATPGGTPGDGNADPAEGDAILLDVTDQTWGAVLAHRLSNSSTLGELNPALISGYLVKRGGTKLEDPPVVLEVNIVHADNNPRMYEPLMREMLTYFRGLGTLARARGIVDKGTDIRPWHIAAAEKGVRALYLLM
Length1537
PositionKinase
OrganismColletotrichum orchidophilum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum.
Aromaticity0.06
Grand average of hydropathy-0.364
Instability index45.81
Isoelectric point5.13
Molecular weight166210.36
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10370
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.06|      16|      18|     965|     980|       1
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  965-  980 (33.12/16.95)	PDVPLLGP.PNRLH..PRP
  983- 1001 (21.94/ 8.50)	PRDNAEPPkPNNLFqiPAP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     453.62|     132|     369|     766|     949|       2
---------------------------------------------------------------------------
  101-  216 (160.43/84.27)	EPISLFKGRAQGQQAANTPTSS.SSSNSALDL.........SLRN.PQMGNSGPPSSSD.PD.SKPPSAGALDSK...GAGSVPIKEAY.....EQFI.TAVLSTT..SASFC..N..RVSAIPLNH.RTV..LLPskvtrdgQTER....................
  800-  949 (183.58/189.68)	DDISLVSDQDDSSTSEDEPTSPfKSSIRRLNLdddvashvtSLRDiESVEDSDPTLALDLPKLAKAEASEILITRyfeDAESLPIHLSL...pDEDTVTTAQIVTE..QAVTG..NL.RIRDAHANTLNTA..IIP.......ETRRQLSSLGRTalqALREVIPAC
 1220- 1319 (109.61/48.70)	................................................LEQSLPR.GIDF.KLSNASSSSLM.......HENTCIHIAYaqsiDERWITAAWTDNRgcQQMTAsyNLgRRGKALSTSLNEVchVIW.......ETTHDLISKWKV...HWRVIISKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.22|      15|      16|     745|     759|       3
---------------------------------------------------------------------------
  745-  759 (28.96/17.00)	QGPPTTDYLRRHGKG
  764-  778 (26.26/14.73)	KQPEHTNALIRTITG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.85|      15|      16|     542|     556|       4
---------------------------------------------------------------------------
  542-  556 (28.88/16.53)	NENGKNRTDAFLGGD
  559-  573 (27.96/15.76)	NLFGDMGPDIFGDAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     195.32|      64|     374|     255|     330|       5
---------------------------------------------------------------------------
  255-  330 (100.81/82.15)	EPSSPsqlalgsqILAAPfgVLANYQGFV...G.........GGLSYPELGLgqTPDAQFWRS....ADARSSQWRDTCVK..ILQSRGLSPAL
  631-  712 (94.51/52.95)	EPSPP........IFAKP..ELKHARSTLmeeGkqrsnadraGGLKRESSPF..DPDTVYKRVraslADVHSTPHRTPARKgsIFDSVDFDPIL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.13|      75|      88|    1023|    1101|       6
---------------------------------------------------------------------------
 1023- 1101 (117.60/95.84)	ESL..GLGPAQGTKDvNVVCVFPH.WDGMSDVAAAfLDRMRNVYELLKLGSFERLATSSN.VTDGLVPFeaDKIATSPGNVSP
 1112- 1190 (115.53/78.73)	EALnqGLISANASEK.NFVVYFVYpPDHPGSIVEA.CTAFQQLFEMHRRSLTEKRQTPVNeLVLQLVPL..DFLTSSTGIVEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.64|      22|      24|     427|     449|       9
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  427-  449 (35.39/25.43)	AAAKQEASAAAPTQqPNG.NSPLG
  453-  475 (38.24/22.67)	ASNAAAAGAMYPTP.PDGvQNPLG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10370 with Med13 domain of Kingdom Fungi
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