<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10365

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSFHPRTPQSPSQFSPATSDLTSSMNSSAPSTATTLPTPAHSVNGSASQPSDMSHDIVMGDDSPHKRKRPLEDLGDREQKKAHIEDSKTGIEALHLDVGEKYLLCQTPHHERLPRITEDLFEMFNLSGIAAEVAREKPNGEKNALRKTYKGQIKKLGILGRFDSVAQDWDAPREKDGESGDKKREVYHGFRELLEIPDAEFWGTRQDPIASGLSGTVKSILNRATTMAKGPIPVKDWDSSVLGDLAPGSIDALRQGLSGKVTAPGTPSATTPNPFARKQQQGPQGAVRPQRTTKKRGYGDNSFEGYGEGFPDDGYSTGDGDDRGGQKRRKKVSDDLFMLSVTVADSLQDGNGQTFPNTMRPQGYGPSAVGA
Length371
PositionHead
OrganismColletotrichum orchidophilum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum.
Aromaticity0.06
Grand average of hydropathy-0.839
Instability index43.94
Isoelectric point6.52
Molecular weight40188.10
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10365
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     204.18|      55|      67|     167|     225|       1
---------------------------------------------------------------------------
  135-  163 (28.31/10.47)	......REKpNGEK...NALRKTYK..............................GQIKklGILGRFD
  167-  225 (92.86/58.86)	QDWDAPREK.DGESG..DKKREVYHGFRELLEIPDAefwgTRQDPIA....SGLSGTVK..SILNRAT
  235-  293 (83.00/43.50)	KDWDSSVLG.DLAPGsiDALRQGLSGKVTAPGTPSA....TTPNPFArkqqQGPQGAVR..P..QRTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.10|      26|      43|     300|     325|       2
---------------------------------------------------------------------------
  300-  325 (50.33/25.08)	DNSFEGYGEGFPDDGYSTGDGDDRGG
  345-  370 (49.77/24.73)	DSLQDGNGQTFPNTMRPQGYGPSAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.25|      11|      43|      64|      74|       3
---------------------------------------------------------------------------
   64-   74 (21.64/13.53)	PHKRKRP..LEDL
  108-  120 (17.61/ 9.69)	PHHERLPriTEDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10365 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LRQGLSGKVTAPGTPSATTPNPFARKQQQGPQGAVRPQRTTKKRGYGDNSFEGYGEGFPDDGYSTGDGDDRGGQKRRKKVSDD
2) MLSVTVADSLQDGNGQTFPNTMRPQGYGPSAVGA
3) MSFHPRTPQSPSQFSPATSDLTSSMNSSAPSTATTLPTPAHSVNGSASQPSDMSHDIVMGDDSPHKRKRPLEDLGDREQKKAHIEDSKTGI
253
338
1
335
371
91










Molecular Recognition Features






MoRF SequenceStartStop




1) KRRKKVSDDLFMLSVTVAD
327
345