<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10364

Description Transcription mediator subunit Med12
SequenceMGVQPRPPQQRTLSSSGLSVQRPTQQRTLSAQYLPQSPVRKDNLIDLTGDANDAAVAQNRYGTLPRRGGSRLKLELSNEAMLAQHAVSENPKTLTPSRLMPKNEASNLTDKSSPASAKGQPVDADNPPMPMPKRRPRFVVPAAAKDAPAPVIAVKKDGRPKPYHIETPSVAPRYAPFSKPRTDAAAKPGFGGSSSGARDIPDMGHADFFPWTGNHPEDQYTESIIKNGYYDKQPQASVETQSAKAALFPALKHKSGLNLLSNIFVGVLNQRKLNGQISSPSTFKPPPRVTLTDTKREMWLRDLANPSISLRRLSRTIPHGIRGKVLLDHCLNKNVPTERAVWLVKCVGANEIRAFKRKGNGPGPFVLGGEAKWLRDWTVFVEQFVEGVSTAFGDNDWKAKVQYAIRLATHLYAEQLLDRDHYMDWLVSGLENSTQSKLPMWILTTQIYWKDLLRLRRYGRRLVNALLSHLNTIHNDPDRDILVQLSTRLTSLLTPLLSAYSDNFVSPATWFKYRDALLASIPIENDFAQNAFKWINVRNEQLVASASNSQPANRQILVKHLDTSFMSLYSPDLAMQCWAVSEDKGMIVRTLLEWCTSSHRPGMAKVYITASLLRTWVATGVDMTTAILEFLSHSPPTETTSKKVFHQLVSEIVRSGDFQLQGYIFWLIARGGLRKPADTEAEGPCATRLLVDLPLHALNSSAQATRASLLRRASYDVNDEAEDINTALKCVQHVMGLPLPPGDPMLQRKPVPVGKLCRLISNSNRALQTEVGARLLQIFTKEIIMTKNGPQVSPGMFNFARAILEAASDYTVLVEIVKLVSRASNPEILASCADTFNVHLPIFAALGVAKELFDALMERLRAVSDEQGPAARPLLASLANLSTLIPGYTNTAVYLRQQLHQCDRNNPIDACSPVSDNMTAQLQDAEGELHEEIEKLLMSGTSVDRPTMDRLFQTVVGRLESCWSKSPDRQRAYSALLGRLRIFDAQHFDVRMTDWVHHISALKARPGLENIYPLLISMGCLTLPIILTTTSVEASRIATNPSVPPNSTTTYMQEVLSLTTMPLPAKTALTPEETYRFYIQQRVAPRQNHKDMVYLVRNALVEFSRLQGVVDLSLLPLVNAAIKDTALQLLKFLVLRDPPSVVQALGIKNPEPALTTLFAQITTKLLLPDAGDGSPLTFETVLELANEFTLPFCQLKLSVGLAADSTTSPGGGEQALTQVDMFSRAMDRAVSANNVMWTSMLPYLSEDITEHLKKQAHLRFLGLFPSQKNPPTADPLSQESTQLAASLLSVVEAILRGRPPVRTSQLTSGMVEKIAELWELLATDDVNKRDLRASILRYWLPALLRFITLHTTVNEPVPAPAQPQAANNMKPPVNAAAFEIRARILIILSGLTLELDNLAFQDTQSSRPLGQQVFDLALLLVDTLPDDVRLQCVRVLLTGGTMQNPASSDVRLRYLFSHMPPPTEQFVLAHRQQLTTQQTGPPRVKMPISMQGTDKLTPFIYRKWEMLSEPTPNVGENDTALSLTLFEAIKIQ
Length1532
PositionKinase
OrganismColletotrichum orchidophilum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum.
Aromaticity0.07
Grand average of hydropathy-0.205
Instability index43.82
Isoelectric point9.04
Molecular weight169802.29
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10364
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     299.08|     106|     182|     667|     781|       1
---------------------------------------------------------------------------
  667-  781 (153.15/175.02)	LiARGGLRKPAD................TEAEGPCATRLLVDLPLHALNSSAQATRASLLRRASyDVNDE......................................AEDINtALKCVQHVMGLPLPPGDPMLQRKpvpVGKLcrLISNS.......NRALQTEVGaRLLQIFTK
  799-  965 (145.93/124.77)	F.ARAILEAASDytvlveivklvsrasnPEILASCADTFNVHLPIFAALGVAKELFDALMERLR.AVSDEqgpaarpllaslanlstlipgytntavylrqqlhqcdrNNPID.ACSPVSDNMTAQLQDAEGELHEE...IEKL..LMSGTsvdrptmDRLFQTVVG.RLESCWSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     333.74|      76|     187|    1259|    1335|       2
---------------------------------------------------------------------------
 1259- 1335 (116.29/56.26)	RFLGLFPSQKNPPTADPLSQESTQLAASLLSVVEAIlRGRPPVRTSQLT..............SGMVEKIAELWELLA..TDDVNKRDLRASI
 1345- 1432 (103.81/46.76)	RFITLHTTVNEPVPAPAQPQAANNMKPPVNAAAFEI.RARILIILSGLTleldnlafqdtqssRPLGQQVFDL.ALLL..VDTLPD.DVRLQC
 1451- 1523 (113.63/51.83)	RLRYLF.SHMPPPTEQFVLAHRQQLTTQQTGPP....RVKMPI.SMQGT..............DKLTPFIYRKWEMLSepTPNVGENDTALSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.57|      22|      73|     476|     497|       3
---------------------------------------------------------------------------
  476-  497 (38.53/24.14)	DP.DRDILVQ.LSTRLTSLLTPLL
  550-  573 (32.05/18.80)	QPaNRQILVKhLDTSFMSLYSPDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.45|      20|      24|     114|     137|       4
---------------------------------------------------------------------------
  114-  137 (35.20/26.48)	PASAKgqpvDADNPPMPMPKR.RPR
  141-  161 (30.24/13.39)	PAAAK....DAPAPVIAVKKDgRPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.81|      14|      26|      65|      78|       5
---------------------------------------------------------------------------
   65-   78 (25.85/18.05)	PRR.GGSRL..KLELSN
   91-  107 (16.96/ 8.72)	PKTlTPSRLmpKNEASN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.27|      19|     182|     172|     199|       6
---------------------------------------------------------------------------
  172-  190 (34.53/36.10)	PRYAPFSKPR.TDAAAKPGF
  210-  229 (31.74/12.43)	PWTGNHPEDQyTESIIKNGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.13|      24|     566|     304|     327|       8
---------------------------------------------------------------------------
  304-  327 (42.10/24.27)	ANPSI.SLRRLSRTIPHGIRGKVLL
  871-  895 (37.03/20.44)	ARPLLaSLANLSTLIPGYTNTAVYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.52|      48|     403|     588|     640|       9
---------------------------------------------------------------------------
  588-  640 (75.77/65.80)	VRtLLEW....CTSSHRPGMAKVY...ITASLLrtwvATGVDMTTAILE.....FLSHSPPTETT
  990- 1049 (69.76/45.33)	VR.MTDWvhhiSALKARPGLENIYpllISMGCL....TLPIILTTTSVEasriaTNPSVPPNSTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.32|      13|      15|       1|      14|      10
---------------------------------------------------------------------------
    1-   14 (23.00/19.08)	MGVQpRPPQQRTLS
   18-   30 (25.31/14.70)	LSVQ.RPTQQRTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.82|      15|      76|     285|     302|      11
---------------------------------------------------------------------------
  285-  302 (25.92/24.36)	PPPRVTLTDTKremWLRD
  362-  376 (29.91/18.29)	PGPFVLGGEAK...WLRD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10364 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MGVQPRPPQQRTLSSSGLSVQRPTQQRTLSAQYLPQSPVRKDNLIDLTGDANDAAVAQNRYGTLPRRGGSRLKLELSNEAMLAQHAVSENPKTLTPSRLMPKNEASNLTDKSSPASAKGQPVDADNPPMPMPKRRPRFVVPAAAKDAPAPVIAVKKDGRPKPYHIETPSVAPRYAPFSKPRTDAAAKPGFGGSSSGARD
1
199










Molecular Recognition Features






MoRF SequenceStartStop




1) FIYRKW
2) KRRPRFVVPAAAK
1499
133
1504
145