<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10361

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGRVVRGVQRAALEQWSEFIAKSLAHRIDPEKFESYVPFLQAKHPLPPVAVADLFLRPQPHNHESLDPRIPRYLQVLFGLKYIDTPSILKALYKYSTSRGHSREAAQLPDVENATIKFPRWGSSYAAEEVMFYRLTKSVAQGTAIQNTGTDLEIANVMAKWIALFTDAATAFTVDVMGQLHNSQVREEMESARAAFVALLLGVCENQVVLKALSKPEAQEIRKALSESLANFVPTIMQSAGPIATRLDMFRTSTLAGFEPVDEQKNKSNAEIEDLFDSTVALENFVVSELPIVNSRAGLYIYLNAALVGRPLIDDLAIFNYLNNRYQGDVQSTTVDLILVSFDVLANAASRNEGNQAAHLLRSFLMNKLPILIESLSKHMYGPVNAEYCITEALSRVDTTTFPTLSSMFDETRSGNPFTDSVREDFCWACCLHGLVRESSIETLLGETPYQSLPAGGRYVKENLVAECLADPERMQALIGELDSKDGNAGAVCQALTEVGSRCSQTPSDADLFQVLGQLCRNKETMSLKLLCGQLAQKPLSLDVMLMFEKPATILHPLCDLLDNWKYDEDQGEYQPVYEEFGSILLLVMAFAYRYSLSASDMGIISSDSFVGRLLGHGHQSRPLEELSDQEKGHLNGWIHGLFDSEAGGLGDELMSSCPPQDFYLLVSTLFHNIVLAFSTGHLTEESLRGGIEYLVDTFLLPSLVVAITYLANSLWVERSDCQKAVVRVLNSVLAPTSISNEAQAMLSSVMNIVAKPLEHSLRAYQRSDPKSQEVEPLLKAIKDSIPLSRRTGAADHTELDAWSMGGFSNSIRQTLQQLVQWSIHPTMDRMPPAYTHRQMLVAMKLLGAKRLLQLLYEDVRQQTETGSGSIIYDVATALVCAPDVVNMPSGPINFIDNSGNVPAPVQRKLTLREVLKSDAEECKKLQKVDMNMAEIVVRLYRKVETQMAVSQAEVIQADTMLQNDLGLSLDAGAGSLDDAMAAAAANVAQGDGMSVDNVSLDLGLGGVGGDLGLGGSSNNGGGSLDLGADDLFSGLVAGDDFQWDNMDLS
Length1051
PositionTail
OrganismColletotrichum orchidophilum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum.
Aromaticity0.07
Grand average of hydropathy-0.071
Instability index41.75
Isoelectric point4.84
Molecular weight115166.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10361
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.77|      32|     121|      60|      95|       1
---------------------------------------------------------------------------
   64-   95 (56.27/41.30)	HESLDPRIPRYL..QVLFGLKYIDTPSILKALYK
  826-  859 (52.50/27.78)	HPTMDRMPPAYThrQMLVAMKLLGAKRLLQLLYE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.41|      22|      23|     992|    1013|       2
---------------------------------------------------------------------------
  968-  989 (19.44/ 8.36)	..GLSLDagAGSLDDAMAAAAANV
  992- 1013 (38.55/24.60)	GDGMSVD..NVSLDLGLGGVGGDL
 1022- 1037 (27.41/15.13)	GGG........SLDLGADDLFSGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.33|      15|      16|     760|     774|       4
---------------------------------------------------------------------------
  760-  774 (27.12/18.67)	EHSLRAYQRSDPKSQ
  777-  791 (25.22/16.83)	EPLLKAIKDSIPLSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.67|      17|      23|     235|     257|       5
---------------------------------------------------------------------------
  235-  251 (30.38/12.16)	PTIMQSAGPIATRLDMF
  261-  277 (27.29/18.79)	PVDEQKNKSNAEIEDLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.50|      27|      52|     305|     332|       6
---------------------------------------------------------------------------
  306-  332 (47.61/28.15)	AALVGRP.LIDDLAIF.NYLNNRYQGDVQ
  358-  386 (35.89/18.45)	AAHLLRSfLMNKLPILiESLSKHMYGPVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.60|      39|     418|     488|     526|       9
---------------------------------------------------------------------------
  488-  526 (69.00/50.87)	GNAGAVCQ...ALTEV....GSRCSQTPS.DADLFQVLGQLCRNKET
  901-  947 (51.60/36.06)	GNVPAPVQrklTLREVlksdAEECKKLQKvDMNMAEIVVRLYRKVET
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10361 with Med5 domain of Kingdom Fungi
Unable to open file!