<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10357

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSVTNIRVLDGFSNIYWRIYTEDPNITNLPGEAPANGFTILKHLSRLKDLELRLRNSDCLVSSYPRRLGLWVFSATPEFESVGCLRSDESKGEQSRLIVGSSTLKVSASGSVTPRELVKNLSTDPQTAGGSTGSQRPQANPTPTRRCDPPRVTDPLHCRREGLLRDSRIVDDDPSSISALTTLQVQLTSVGKLTVSLQTTSQPGIAPLCRLGESPSDVCDVAPGADIWLSPSGSVARLVSTSPGPPNASPPYPSTGSIGTDSLGAAGRKQWKANVLEWLRNFGLPIDSVDETAWVEIEIWEPFYSRLAGETLRLNEDKSSTLPLKRVLWPAVYCFRRTKSASPGSSQWMENACPVVSDPLDFARNWRVVEKPTHDETSPKPPSSHPEQQSRNPEPSSATTDILEGIESLSRASEYPDLQTISLVYPTPPDGAAAMGLNLAGPSDTFAEEPELVPSLLQNQNKPKYYEQFTTKDRSDADPSAGFGPLGGLAVGSGLYDTNGDDDLFGDMDERDFGTKGITDADFNFFDDPSFAAMDTDDPADDDAQEMLDMTNLEAAEAHPTVSEDAILEDIPAQETPAEDLEVTQASPNEVTPKVQPEHLIAEESTEAASPHIEQNQTISPPLSPVEIKRILLPEPNGDSHVPTKGNRKQSYYNPVAFKPNMSSWDQKYGADGKFRFTTAGPSASKVYTNSDIPTVGMPRRRIKKYPTAGAGAMGLDGHASPSSEGQHLQTVLDSSSDTSDDSDNSASESDAPPLLSRKRKRARSNSVSSPALSQVKSLGEGDQEIPVHRPEHSIFLGNLLSTFSDWSMTGYFSLAENRLFPVLTRKDMQIQIAQLFVDQITQSSLDHKLDGGFCLSDLETKAYSVQSFLEEEGVLGGIERLDLNSWISLQDNEQPSPAPNGTVARQLSQRKETGKGSITKLSPPHLRVRRGKEYLEALPPAISFWETFGLEPADGPKDISAYCIHPQIAGDAADVFLERLGLLYSSCNLGKHGRGCRSSAFEGGLCSWDVGPLDTAQFLPAMQSLKVICEELGTALLKSSPSSDSLVIYIINPFAHASALVDICSAFWCLFQKYIADTGKQQARQLNEVVLQIIPISFIMSTGSVVVPPQTQYLNLALEIYSRCPPQALQSSLVNCAPPVLLAEPLPRTISFRLASEKTSPLQEGKCLHIAYSKSQDQRWIGVAWSDNSGALQRTISYNLRYRNASAVRSISDVRSEIWAATKDIVDRIQARWKVFVVSTEPVDQDEVDAWTGFIEQYNKANSIPLELTILSVNTAPDLHLEPPFLPMSMSVFNPQTSSTPVATPNASGNVFSPDQSGTAPTPPSGGNAPANASTPTEPTLEAESESVLTDICDESWGVILSHRLNNSPHLTEYRPALASGYLLRRKGDTDGDGVYAMTLNLIYAQRPSSCETILRETLGMYRDLGTLARARGTRTVQRNTLPWHIATAVRAQEMLSHVL
Length1466
PositionKinase
OrganismAspergillus bombycis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.399
Instability index55.42
Isoelectric point4.93
Molecular weight159675.71
Publications
PubMed=27664179

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP10357
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     545.60|     115|     147|     157|     271|       2
---------------------------------------------------------------------------
   23-   93 (75.26/31.44)	........................................R.IYTEDPN....ITNL........................P..GEAP....ANGFTILKHLSRLKDLELRLRNSD.C.LVSSYPrrlGlwVFSATP......EF...ES..VGCL..RSD.....
   95-  153 (31.44/ 8.72)	.................................S.KGEQSRlIVGSSTLKVSASGSVTprelVKNLSTDPQTAGGSTGSQrP..QANP......TPTRRCD.................................................................
  157-  271 (194.10/93.03)	VTDPLHCRRE.......................G.LLRDSR.IVDDDPSSISALTTLQ....VQLTSVGKLTVSLQTTSQ.P..GIAPLCRLGESPSDVCDVAPGADIWLSPSGSV.ARLVSTSP...G..PPNASP......PY...PS..TGSI..GTDSLGAA
  304-  417 (144.82/67.49)	IWEPFYSRLA.......................GeTLR.....LNEDKSSTLPLKRVL....WPAVYCFRRTKSASPGSS.Q..WMENACPVV...SDPLDFARNWRVVEKPTHD......ETSP...K..PPSSHPeqqsrnPE...PSsaTTDIleGIESLSRA
  419-  542 (99.99/44.25)	.........EypdlqtislvyptppdgaaamglN.LAGPSD.TFAEEPELVPSLLQNQ....NKPKYYEQFTTKDRSDAD.PsaGFGPLGGLAVG.SGLYDTNGDDDLF....GDMdERDFGT.K...G..ITDADF......NFfddPS..FAAM..DTD.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.44|      11|      15|     753|     763|       3
---------------------------------------------------------------------------
  753-  763 (19.64/10.99)	SESDAPPLLSR
  770-  780 (18.80/10.11)	SNSVSSPALSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.50|      14|      15|     916|     930|       4
---------------------------------------------------------------------------
  916-  930 (20.92/16.55)	RKETGKGSITKLsPP
  933-  946 (25.58/15.29)	RVRRGKEYLEAL.PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     361.34|     114|     147|    1011|    1157|       5
---------------------------------------------------------------------------
 1011- 1139 (171.70/136.52)	LCSWDVGPLDTAQFLPAMQSLKVICEELGTALLKSSPSSDSLVIYIINpFAHASA...LVDICSAFWCLfQKYIADtgKQQARQlnevvlqiipISFIMSTGSVVVPPQTQYLNLaLEIYSRCPPQALQSSL
 1160- 1276 (189.64/139.93)	LASEKTSPLQEGKCLHIAYSKSQDQRWIGVAWSDNSGALQRTISYNLR.YRNASAvrsISDVRSEIWAA.TKDIVD..RIQARW..........KVFVVSTEPVDQDEVDAWTGF.IEQYNKANSIPLELTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.04|      12|     133|    1140|    1151|       6
---------------------------------------------------------------------------
 1140- 1151 (23.45/12.56)	VNCAPPVLLAEP
 1279- 1290 (23.59/12.68)	VNTAPDLHLEPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.26|      27|     133|     565|     601|       7
---------------------------------------------------------------------------
  544-  565 (29.46/11.81)	...........PADDDAQEMLDMTNL.....EAAEA....HP
  566-  602 (33.27/37.82)	TVSEDailediPAQETPAEDLEVTQA.....SPNEVtpkvQP
  605-  633 (25.53/ 9.52)	LIAEE.......STEAASPHIEQNQTispplSPVEI......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.45|      21|     278|     422|     442|       9
---------------------------------------------------------------------------
  422-  442 (40.30/21.00)	DLQTISL....VYPTPPDGAAAMGL
  697-  721 (33.15/15.97)	DIPTVGMprrrIKKYPTAGAGAMGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10357 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KYGADGKFRFTTAGPSASKVYTNSDIPTVGMPRRRIKKYPTAGAGAMGLDGHASPSSEGQHLQTVLDSSSDTSDDSDNSASESDAPPLLSRKRKRAR
2) NFFDDPSFAAMDTDDPADDDAQEMLDMTNLEAAEAHPTVSEDAILEDIPAQETPAEDLEVTQASPNEVTPKVQPEHLIAEESTEAASPHIEQNQTISPPLSPVEIKRILLPEPNGDSHVPTKGNRKQSYYNPVA
3) PDGAAAMGLNLAGPSDTFAEEPELVPSLLQNQNKPKYYEQFTTKDRSDADPSAGFGPLGGLAVGSGLYDTNGDDDLFGDMDERDF
4) PRELVKNLSTDPQTAGGSTGSQRPQANPTPTRRCDPPRVTDPLHCRREGLLR
5) VFNPQTSSTPVATPNASGNVFSPDQSGTAPTPPSGGNAPANASTPTEPTLEAESES
6) WRVVEKPTHDETSPKPPSSHPEQQSRNPEPSSATTDILEGIESL
673
529
434
119
1298
371
769
662
518
170
1353
414










Molecular Recognition Features






MoRF SequenceStartStop




1) KYGADGKF
2) MPRRRIKKYPT
3) RDFGTKGIT
4) RKQSYYNPVA
5) VEIKRILLPE
673
703
516
653
631
680
713
524
662
640