<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10357

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSVTNIRVLDGFSNIYWRIYTEDPNITNLPGEAPANGFTILKHLSRLKDLELRLRNSDCLVSSYPRRLGLWVFSATPEFESVGCLRSDESKGEQSRLIVGSSTLKVSASGSVTPRELVKNLSTDPQTAGGSTGSQRPQANPTPTRRCDPPRVTDPLHCRREGLLRDSRIVDDDPSSISALTTLQVQLTSVGKLTVSLQTTSQPGIAPLCRLGESPSDVCDVAPGADIWLSPSGSVARLVSTSPGPPNASPPYPSTGSIGTDSLGAAGRKQWKANVLEWLRNFGLPIDSVDETAWVEIEIWEPFYSRLAGETLRLNEDKSSTLPLKRVLWPAVYCFRRTKSASPGSSQWMENACPVVSDPLDFARNWRVVEKPTHDETSPKPPSSHPEQQSRNPEPSSATTDILEGIESLSRASEYPDLQTISLVYPTPPDGAAAMGLNLAGPSDTFAEEPELVPSLLQNQNKPKYYEQFTTKDRSDADPSAGFGPLGGLAVGSGLYDTNGDDDLFGDMDERDFGTKGITDADFNFFDDPSFAAMDTDDPADDDAQEMLDMTNLEAAEAHPTVSEDAILEDIPAQETPAEDLEVTQASPNEVTPKVQPEHLIAEESTEAASPHIEQNQTISPPLSPVEIKRILLPEPNGDSHVPTKGNRKQSYYNPVAFKPNMSSWDQKYGADGKFRFTTAGPSASKVYTNSDIPTVGMPRRRIKKYPTAGAGAMGLDGHASPSSEGQHLQTVLDSSSDTSDDSDNSASESDAPPLLSRKRKRARSNSVSSPALSQVKSLGEGDQEIPVHRPEHSIFLGNLLSTFSDWSMTGYFSLAENRLFPVLTRKDMQIQIAQLFVDQITQSSLDHKLDGGFCLSDLETKAYSVQSFLEEEGVLGGIERLDLNSWISLQDNEQPSPAPNGTVARQLSQRKETGKGSITKLSPPHLRVRRGKEYLEALPPAISFWETFGLEPADGPKDISAYCIHPQIAGDAADVFLERLGLLYSSCNLGKHGRGCRSSAFEGGLCSWDVGPLDTAQFLPAMQSLKVICEELGTALLKSSPSSDSLVIYIINPFAHASALVDICSAFWCLFQKYIADTGKQQARQLNEVVLQIIPISFIMSTGSVVVPPQTQYLNLALEIYSRCPPQALQSSLVNCAPPVLLAEPLPRTISFRLASEKTSPLQEGKCLHIAYSKSQDQRWIGVAWSDNSGALQRTISYNLRYRNASAVRSISDVRSEIWAATKDIVDRIQARWKVFVVSTEPVDQDEVDAWTGFIEQYNKANSIPLELTILSVNTAPDLHLEPPFLPMSMSVFNPQTSSTPVATPNASGNVFSPDQSGTAPTPPSGGNAPANASTPTEPTLEAESESVLTDICDESWGVILSHRLNNSPHLTEYRPALASGYLLRRKGDTDGDGVYAMTLNLIYAQRPSSCETILRETLGMYRDLGTLARARGTRTVQRNTLPWHIATAVRAQEMLSHVL
Length1466
PositionKinase
OrganismAspergillus bombycis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.399
Instability index55.42
Isoelectric point4.93
Molecular weight159675.71
Publications
PubMed=27664179

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10357
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     545.60|     115|     147|     157|     271|       2
---------------------------------------------------------------------------
   23-   93 (75.26/31.44)	........................................R.IYTEDPN....ITNL........................P..GEAP....ANGFTILKHLSRLKDLELRLRNSD.C.LVSSYPrrlGlwVFSATP......EF...ES..VGCL..RSD.....
   95-  153 (31.44/ 8.72)	.................................S.KGEQSRlIVGSSTLKVSASGSVTprelVKNLSTDPQTAGGSTGSQrP..QANP......TPTRRCD.................................................................
  157-  271 (194.10/93.03)	VTDPLHCRRE.......................G.LLRDSR.IVDDDPSSISALTTLQ....VQLTSVGKLTVSLQTTSQ.P..GIAPLCRLGESPSDVCDVAPGADIWLSPSGSV.ARLVSTSP...G..PPNASP......PY...PS..TGSI..GTDSLGAA
  304-  417 (144.82/67.49)	IWEPFYSRLA.......................GeTLR.....LNEDKSSTLPLKRVL....WPAVYCFRRTKSASPGSS.Q..WMENACPVV...SDPLDFARNWRVVEKPTHD......ETSP...K..PPSSHPeqqsrnPE...PSsaTTDIleGIESLSRA
  419-  542 (99.99/44.25)	.........EypdlqtislvyptppdgaaamglN.LAGPSD.TFAEEPELVPSLLQNQ....NKPKYYEQFTTKDRSDAD.PsaGFGPLGGLAVG.SGLYDTNGDDDLF....GDMdERDFGT.K...G..ITDADF......NFfddPS..FAAM..DTD.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.44|      11|      15|     753|     763|       3
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  753-  763 (19.64/10.99)	SESDAPPLLSR
  770-  780 (18.80/10.11)	SNSVSSPALSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.50|      14|      15|     916|     930|       4
---------------------------------------------------------------------------
  916-  930 (20.92/16.55)	RKETGKGSITKLsPP
  933-  946 (25.58/15.29)	RVRRGKEYLEAL.PP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     361.34|     114|     147|    1011|    1157|       5
---------------------------------------------------------------------------
 1011- 1139 (171.70/136.52)	LCSWDVGPLDTAQFLPAMQSLKVICEELGTALLKSSPSSDSLVIYIINpFAHASA...LVDICSAFWCLfQKYIADtgKQQARQlnevvlqiipISFIMSTGSVVVPPQTQYLNLaLEIYSRCPPQALQSSL
 1160- 1276 (189.64/139.93)	LASEKTSPLQEGKCLHIAYSKSQDQRWIGVAWSDNSGALQRTISYNLR.YRNASAvrsISDVRSEIWAA.TKDIVD..RIQARW..........KVFVVSTEPVDQDEVDAWTGF.IEQYNKANSIPLELTI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.04|      12|     133|    1140|    1151|       6
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 1140- 1151 (23.45/12.56)	VNCAPPVLLAEP
 1279- 1290 (23.59/12.68)	VNTAPDLHLEPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.26|      27|     133|     565|     601|       7
---------------------------------------------------------------------------
  544-  565 (29.46/11.81)	...........PADDDAQEMLDMTNL.....EAAEA....HP
  566-  602 (33.27/37.82)	TVSEDailediPAQETPAEDLEVTQA.....SPNEVtpkvQP
  605-  633 (25.53/ 9.52)	LIAEE.......STEAASPHIEQNQTispplSPVEI......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.45|      21|     278|     422|     442|       9
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  422-  442 (40.30/21.00)	DLQTISL....VYPTPPDGAAAMGL
  697-  721 (33.15/15.97)	DIPTVGMprrrIKKYPTAGAGAMGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10357 with Med13 domain of Kingdom Fungi
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