<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10356

Description Serine/threonine protein kinase
SequenceMSYQSNPPSYQSHAASHRPIPSYNPLAAVNAPAGTFLPGTKVQVGNHRVIVEKYLSEGGFAHVYVVRLPQPVEGSDRAVLKRVAVPDKSALANMRTEVETMKKLKGHRHIVKYIDSHASQLRGGGYEVFLLMEFCSGGGLIDFMNTRLQHRLTEPEIIQIFSDVAEGVACMHYLKPPLLHRDLKVENVLISRHGTSSVYKLCDFGSTAPPRPAATSAAEGRLIEDDVQRHTTLQYRSPEMIDVYRKQPIDEKSDIWALGVLLYKLCYYTTPFEEVGQMAILNATYKFPSYPVFSDRLRMLIAWMLKEHPQKRPNIYEVVQEVCHMQGKEVPIRDIYANRSTSEARRYQELPPSPTETPPVGAVFSPPVQETQIIPEIAPMRRGRPTKPTSSQHTSAKPSPSPFRGGSTDPFAVLDGSQKSRDSADEFTNRFPSLDQFDILHEKGGTFDFEPAFAETKQEDDGLAQRLTNALADEAFAKRPSPAVNEQTPQSPAQKPPQQSHVKSRPSESFNYREEPQQSPVPLYQPVPQKPTMVSTGTMTSPPHTPSVPELKPPSRPIYRFPSSDHQRRPSSQPWPADGDKKVSRPLNPPSPTKPSADPRTSADRISDLSTSSSRPSLEGMRPSTLELEELTSRSKSANSRSRPFSVQATSKYDFGRGSESARSSLDIPRPSYDMGAPLQHARTEADRANISSDIDYLRAREEESNRKKEKRYSGTSKHTKRSSLSTLSLSGTKTLFAGRFGDAFRRIGRAPAELSDAENDDISPEMRRELERRRLSQEEKRVANAAAEYRRQVAERGEGGFRPDTRSSIQNRVQTFLEESNKSAPAPKTATGYGRFTEEMNPALPAKQNEPLPEPRINTRAAGPLYGSQGQASPVKDRWETAGLPRQETTNSGYAQSQRTGSSRPAAPPKPKSLRVRGSEAISERSQATPTTPSEDWEANFSRRFPSLSGLEMETEIELPNIPLRTKESTKMAPITLSQVDTDLKEAIQHLFEIQSAVHGYLGPETQQELVRKIKSLTQTLSALHKNTADPNTEIPVGNPRDPNLGSVQLPPEIIDYVDAARNPDIYTREFVELVQRGNQDLKGKREAFAEFRDVLARELRSAVPGCRGEVERVMEGLGVGVGSGGREQGRESTRGRDRDQRL
Length1144
PositionMiddle
OrganismAspergillus bombycis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.788
Instability index63.08
Isoelectric point9.00
Molecular weight127401.24
Publications
PubMed=27664179

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10356
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     214.81|      34|      55|     487|     520|       1
---------------------------------------------------------------------------
  351-  375 (31.09/ 9.49)	..PPS.PTE.....TPPVGA.VFSPPV......QETQIIP
  378-  410 (26.41/ 6.84)	....A.PMRrgrptKPTSSQHTSAKPSPS.PFRGGSTD.P
  487-  520 (60.16/25.93)	QTPQS.PAQ.....KPPQQSHVKSRPSESFNYREEPQQSP
  544-  568 (34.35/11.33)	HTPSV.PEL.....KPP......SRPIYRFPSSDHQR...
  599-  625 (29.64/ 8.66)	..PRT.SAD.....RISDLSTSSSRPS.....LEGMRPST
  631-  665 (33.17/10.66)	LTSRSkSAN.....SRSRPFSVQATSKYDFGRGSESARSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.09|      10|      63|     522|     531|       2
---------------------------------------------------------------------------
  522-  531 (21.78/ 8.94)	PLYQPVPQKP
  586-  595 (21.31/ 8.57)	PLNPPSPTKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.98|       9|      63|     199|     209|       3
---------------------------------------------------------------------------
  199-  209 (15.15/16.09)	YKLCDFgsTAP
  263-  271 (20.83/13.10)	YKLCYY..TTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.75|      16|      19|     845|     860|       4
---------------------------------------------------------------------------
  845-  860 (29.57/15.57)	LPAKQNEPLP.EPRINT
  866-  882 (23.18/10.35)	LYGSQGQASPvKDRWET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.49|      20|      20|     755|     774|       6
---------------------------------------------------------------------------
  755-  774 (34.10/17.29)	LSDAEN..DDISPEMRRELERR
  776-  797 (27.39/12.68)	LSQEEKrvANAAAEYRRQVAER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.60|      25|      25|     984|    1008|       8
---------------------------------------------------------------------------
  984- 1008 (43.31/32.14)	DLKEAIQHLFEIQSAVH.GYLGPETQ
 1010- 1035 (36.29/25.63)	ELVRKIKSLTQTLSALHkNTADPNTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.76|       9|      20|     306|     316|      10
---------------------------------------------------------------------------
  306-  316 (13.54/10.66)	KEHPQKrpNIY
  328-  336 (17.22/ 6.42)	KEVPIR..DIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.33|      12|      15|     226|     237|      15
---------------------------------------------------------------------------
  226-  237 (21.22/14.86)	DVQRHTTLQYRS
  242-  253 (21.10/14.73)	DVYRKQPIDEKS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10356 with Med10 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IGRAPAELSDAENDDISPEMRRELERRRLSQEEKRVANAAAEYRRQVAERGEGGFRPDTRSSIQNRVQTFLEESNKSAPAPKTATGYGRFTEEMNPALPAKQNEPLPEPRINTRAAGPLYGSQGQASPVKDRWETAGLPRQETTNSGYAQSQRTGSSRPAAPPKPKSLRVRGSEAISERSQATPTTPSEDWEANFSRRFPSLSGLEMETEIELPNIPLRTKESTKMAPITLSQV
2) LSALHKNTADPNTEIPVGNPRDPNLGSVQL
3) TQIIPEIAPMRRGRPTKPTSSQHTSAKPSPSPFRGGSTDPFAVLDGSQKSRDSADEFTNRFPSLDQFDILHEKGGTFDFEPAFAETKQEDDGLAQRLTNALADEAFAKRPSPAVNEQTPQSPAQKPPQQSHVKSRPSESFNYREEPQQSPVPLYQPVPQKPTMVSTGTMTSPPHTPSVPELKPPSRPIYRFPSSDHQRRPSSQPWPADGDKKVSRPLNPPSPTKPSADPRTSADRISDLSTSSSRPSLEGMRPSTLELEELTSRSKSANSRSRPFSVQATSKYDFGRGSESARSSLDIPRPSYDMGAPLQHARTEADRANISSDIDYLRAREEESNRKKEKRYSGTSKHTKRSSLSTLS
748
1022
371
981
1051
729










Molecular Recognition Features






MoRF SequenceStartStop




1) DIDYLRA
2) RFGDAFRRIGR
3) YGRFTEE
694
740
834
700
750
840