<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10354

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPMIMDDAINVDDLFGESASLELGLPATAPTSNSTKGLAQRLDEMRLLGCCQKIAWSKQGCIAYISQDTLRVNLRHLECRPSDGKWVLSDDTPLHPVAEAHGGQPLVHLCWNEIGSELAVVDSSGRVSIYNIAISLNSLAGQRQATFDSIDDGAQIVGMMWLNIQRSVHAFNVAAMVQGRRAYSPFRRRPIGPFHPAGKAALLCVTRSGIIRLLYQNPDNKWAEISAELKNASYSDRLLTHAAIVATQNGILIATHSACQKIYFYRVQINWTPAQWDPSQLKQAPNQFPVPSFRFMHSKVEAPCIIPSASRNGEATGDELSPSTNPLYCLTRLDIVLAAHDNSAGMTTNPWIIAVFSIPPHATPDHSQQQSPSSVIVRWQLESAPQVLHPKFDEVNSKKNNAQIKPKSVLRRLDDMYCDRYVTTIEQTEHGNVLAVTYDDSSVTFYDPKTMAVLNGTDDTNTLSSLAHAGFHYPPDSAAGLHISFSPSGCNAVTLDGEGQAQLRVMEHSYGAENGLYDENKFSAAIASLTLAFCRGCGSEFNTDDILLILKRQASPDAQISFINEVYRALGVNCNYTQENDKLMSHQYLPKCLSVQAALGFIDKYKSRNFASNVPWTILQLRHASVLYALFLQYLKGGVQAEPPDADAIRILLGNTKWALDLLHYVLNDLLDLADDLESLLSDQEAFAQKLKTINSLPLIILLSSMSRAFLRFICRGLRGIQAGYATAPLTGDAGVYYAEIYQTLETSPVRIDVYEKLLAGVDSTVRHVYVGAGFGDNERPGPEKELLVNGRIPPVLVTAVSTILRQTVPTLKPEIDRMAIYIGDYSWLGLGSDPRAELYRRTRDVDIIKKIPFRSPTSAGSDEAQSGKHNPSQVRRRCVRCCEIMCGAYPPRPQLSSRMMYKLGYVRYCICGGGWTLESDFHR
Length924
PositionTail
OrganismAspergillus bombycis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.179
Instability index42.56
Isoelectric point6.48
Molecular weight102178.24
Publications
PubMed=27664179

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10354
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     497.87|     158|     168|     495|     658|       1
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  495-  658 (254.46/200.88)	LDGEGQAQLRVMEHSYGAENGLYDENKFS...AAIASLTLAFCRGCGS....EFNTDDILLILKRQAS.P...DAQIsFINEVYRALGVNCNYTQENDKLMShQYLPKCLSVQAALGFIDKYKsrnfASNVPWTILQLRHASVLYALFLQYLKGGVQAEPPDADAIRILLGNTKW
  660-  828 (243.41/173.02)	LDLLHYVLNDLLDLADDLESLLSDQEAFAqklKTINSLPLIILLSSMSraflRFICRGLRGIQAGYATaPltgDAGV.YYAEIYQTLETSPVRIDVYEKLLA.GVDSTVRHVYVGAGFGDNER....PGPEKELLVNGRIPPVLVTAVSTILRQTVPTLKPEIDRMAIYIGDYSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     226.16|      72|      97|     280|     371|       2
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  280-  330 (46.82/30.84)	..................................................QLKQAPNQFPVPSFRFMH.SKVEAPCIIPSA..SRngeatgdelspsTNPLYCL
  331-  419 (101.43/57.28)	TRLDIVLA.AHDNSAGMTTNPWIIAVFsippHATPDhsqqQSpssvivrwQLESAP.QVLHPKFDEVN.SKKNNAQIKPKSvlRR............LDDMYCD
  428-  490 (77.92/30.09)	TEHGNVLAvTYDDSSVTFYDPKTMAVL....NGTDD....TN.....tlsSLAHAGFHYPPDSAAGLHiSFSPSGC............................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.40|      36|     829|      50|      91|       3
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   50-   91 (61.95/48.56)	CCQKIawskqgCIAYISQDTLRV....NLRHLECRPSDGKWVLSDD
  882-  921 (67.45/39.32)	CCEIM......CGAYPPRPQLSSrmmyKLGYVRYCICGGGWTLESD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10354 with Med16 domain of Kingdom Fungi
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