<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10352

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRASSASFRLGPPSPSSPAAGSLKANHPSYTSTEHTPQTPTSPPLMSVSAQNYASNFASSQTSPGQATSQPANLSSPPSSVPMSTQASQQPTVGTTNSFPTPASSVNGHFTGATPVDDSEQTEKSFGPEMGATSTTDMNAPMQQTEYRRTDHDRQSEGPSAQTGIRDFGNTGGQDMLNHGDAMDIDKGTADLSNYESSLESLQKEFTSAFHLCKSSHIATGPDPSYDLVSLYGLGPVAKSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPVKHEPGMAGGLRQMTMWPEEEWQNQKVFGKEIKVADMDSALYNLQMRAMKMEPGTVTNNDYWEDILGHEKQSKHAGSGDGSKKTATPSNGARVPSHANGTPTATEPERARPSRGRKRHYDDNSFVGYGEGYADDDDDGAFYSNSEGISKKKRKKV
Length431
PositionHead
OrganismAspergillus bombycis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.919
Instability index48.74
Isoelectric point6.20
Molecular weight46239.14
Publications
PubMed=27664179

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP10352
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.83|      18|      20|     106|     125|       1
---------------------------------------------------------------------------
  106-  125 (28.98/19.37)	SSvnGHFTGATPVDD....SEQTE
  127-  148 (28.85/13.59)	SF..GPEMGATSTTDmnapMQQTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.24|      20|      20|      54|      73|       2
---------------------------------------------------------------------------
   28-   46 (35.94/18.87)	NHPS.YTSTEHTPQTPTSPP
   54-   73 (36.15/19.02)	NYASNFASSQTSPGQATSQP
   75-   93 (33.15/16.79)	NLSSPPSSVPMST.QASQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     284.11|      83|     137|     184|     267|       3
---------------------------------------------------------------------------
  184-  267 (135.91/82.31)	AMDIDKGTADLSNYESSLESLQKEFTSAFHLCKSSHIATgPDPSYDLVSLYGLGPVAKSVARMDPVTGEKINRLRKSYEGKLKG
  324-  406 (148.21/85.89)	AMKMEPGTVTNNDYWEDILGHEKQSKHAGSGDGSKKTAT.PSNGARVPSHANGTPTATEPERARPSRGRKRHYDDNSFVGYGEG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10352 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSDRASSASFRLGPPSPSSPAAGSLKANHPSYTSTEHTPQTPTSPPLMSVSAQNYASNFASSQTSPGQATSQPANLSSPPSSVPMSTQASQQPTVGTTNSFPTPASSVNGHFTGATPVDDSEQTEKSFGPEMGATSTTDMNAPMQQTEYRRTDHDRQSEGPSAQTGIRDFGNTGGQDMLNHGDAMDIDKGTADLSNYESS
2) TNNDYWEDILGHEKQSKHAGSGDGSKKTATPSNGARVPSHANGTPTATEPERARPSRGRKRHYDDNSFVGYG
1
333
200
404










Molecular Recognition Features






MoRF SequenceStartStop




1) KRHYDDNSFVGYGEGYADDDDDGAFYSNSEGISKKKRKKV
392
431