<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10351

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSDSFNLPLRPLTEKRERPDPLPVEIAQINAQYGSFRDVTEDSLRAKIEADKNKDPWSDEEENDNASADEDTTERLDQLYKRRAAIAQFAHQAHMEAMFALDFVSLLLSKHTPRQAEMSMSAYLKQVAPLGSLNSEIVNPPPKPESAARDTKNVSRGWRLQNFNAAASKLLDSATRLESEVASETKYWNEVLAVKEKGWKVSRLPRERQALGVQYGFLEATPIFRDRGLAALRRTNDGSLILDKGLIPLKARTVRVRVRSRGQITGCSKHRLALDNTESVESRILQARDTVYEEELFHELVREARVLGSQGVTTRQNLVQFPVSEEQEVLLDLIDDDQMSPGDEAVSDEHTVVADALGHAIRILLAYAHRQNLRRRTQLPIPLTPKRRQTPEYQLLRPVMAYLQHSSHVRWLESLLNDINQILKSAGIPCDFTATPFSSLSFQRTVNGLPKVEALVQDLLLPYESTFSAQLVTPQSSFRVKVRTNVTTPPLGTHYEISVNMPQYPDVRPPNRIGLQDEVASVLTHFVLLDILTAITHAKGLSANGVKQETGRLLTWQAAYPHNGELLALSSAGQYKKMKVSLSRHELTVRTYSLRGIDGFGKPAADKTPAMRSQTWKSDGTPGQPSLMGFITEVSKE
Length637
PositionHead
OrganismAspergillus bombycis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.462
Instability index46.61
Isoelectric point7.79
Molecular weight71433.17
Publications
PubMed=27664179

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10351
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.47|      29|      32|      14|      44|       1
---------------------------------------------------------------------------
   14-   44 (46.04/34.77)	EKRERPDPLPVEIAQINAQYGsfRDVTE..DSL
   49-   79 (46.43/28.39)	EADKNKDPWSDEEENDNASAD..EDTTErlDQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.84|      27|      31|     198|     228|       2
---------------------------------------------------------------------------
  202-  228 (47.92/36.75)	SRLPRERQ.ALGVQYGF..LEATPI...FRDRG
  230-  262 (28.92/10.99)	AALRRTNDgSLILDKGLipLKARTVrvrVRSRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.77|      11|      30|     514|     524|       3
---------------------------------------------------------------------------
  514-  524 (17.49/ 9.21)	GLQDEVASVLT
  545-  555 (18.28/ 9.91)	GVKQETGRLLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.29|      14|      30|     145|     158|       4
---------------------------------------------------------------------------
  145-  158 (25.77/16.14)	ESAARDTKNVS..............RGW
  172-  199 (15.52/ 7.09)	DSATRLESEVAsetkywnevlavkeKGW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10351 with Med17 domain of Kingdom Fungi
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