<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10350

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHSSAGVQSWGHPLRAVNSGSGHVDASQAVGPPDPQFEKLPTPVPQPQPRQPAVIDLTTSGGDAQEVEPPPKRLRLDLPAAPSARDASPVPGSAGELRSTPGTGGLKPPSLSWRNRPVWSFQAMLSEVPGSNVMNEEDATSVAQGGKPASPPSLPVLPWKYVPESLGANPTLSRAGSPVKEVQTVPYRIETPSVAPVLKGEKVADFSPWTGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQNHSLVTVPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRKLSRTIPHGIRGKALLDQCLNKGIPVSRAVWLAKCVGANEIRAFKRKGTSGTLALGLEAKWVRDWTATVQQFLEGVLGACGSAQWKTKMTYAVSLTARLFFERLLDHDQYLGWFLSSLEAAPVNTVPVWLLMLGIYWDNIIRYRKRGRRLAELLLEKLRQVSALVLMVNILLMGQQVTQPEKVGALQPLIDRLSLYVRRLVLEHTSSVVLPGSWEKHKELISSCLNLKDTVHKTIYQNLCERNSRLQLPKNHQGTAERSPQQRVIQLFDSIRSAHDISSASAACLKTLEDKAVLISKLLEWTATPFRYGLCRVYTGVRLLRKWKMSGIDVDSYILSFLADVRVTSALNMENIYHIISELVRSQTFSVGRYLQWLMAKGVTNTSQPVSSDLCLLKQLPANRLPEHVRNLRNTLLYRAGIPVMEEDSAIAELKLSIAQRLPNIFGAEMGSAMPIEPSQANPTWAVKSEIGQWIRRGVAGHYRDSPRKLSGVSVMVDPGVSALTPDEFYSVREILETYGDLSMLADILKQATRCDDDVVLASVADTVNCHFDCFCVIGATADLFRGLVESYARLKRLGNASLDLLFSLIELGLRIPSEFNTVALLRQDLTRLESKSALAAPSPLSDSIPLALSDVDPSFQAKLNQLLSSGSGMDESTMDAVFYSLIHILESSGSPAKLSANETARYLAYLRPFQPKHFDTMLIRWICGLLKSSTPSMSRILPPLIGVGCVTIHAFVFLVKKLLQSEKVAAVIPNLTGLRVELLQLLVPLISGKSKYADLVTYRFHVAQQEFFLKHPQETLDIICDAVALVDSKAGLDSRQPDIAGCAIELLDILLTQNPEVTVQYCLEGFIGKYSTSTTVLQRALDSLLGFDSLAGPPTMSEAEKVVRMTDDFSLPFCQLKLQMLFNAESGRNVGNGIVDVMFKAAVEDTRSKGSNWVGFVGLMSQDVIRQIRERAERALFSIPLFEEHLEAHGPSGNAKSLETAKLYLTIIEKLAYSVPEAGVQSVAPVLVEKMDLLLHRLVIMQTNFNNVTANRHGAATTQILQSRSNFERALAFWFSAFLRMIVIHRSAFTMPSPAPKPNGLQEQSRLLISILCISLARLPDSVIRLFPATDYFPHPIPSQGCRACPGILLQTHALDVAASLIDTFPDEARQHCARFLKEKCPPFLQYQNDSRFIYLLGPMSDAAALNSLQAASLPSPAAGGSTPTPTPSGALPGAPSNPQTPAMTPAGSSVSLSEGINCVASHLRLQYRGRIMGPYPVRPWELLEDAAPIVGVNDTAVNLKYFDARRVRA
Length1602
PositionKinase
OrganismAspergillus bombycis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.075
Instability index49.51
Isoelectric point8.86
Molecular weight175976.79
Publications
PubMed=27664179

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10350
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     180.40|      42|      48|     160|     201|       1
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   84-  113 (23.75/ 6.87)	......P.SARDASPVPGS.AG.......ELRSTPG..TggLKPPSL.....
  115-  158 (29.73/10.53)	.WR.NRPvWSFQA..MLSEvPGSNVmneEDATSVAQggK..PASPPSLPV..
  160-  201 (70.71/35.60)	PWK.YVP.ESLGANPTLSR.AGSPV...KEVQTVPY..R..IETPSVAPVLK
  210-  252 (56.21/26.73)	PWTgNHP.EDVLNEQTAKQ.GHYDR...TQVSQNES..N..TARPSLYAQLK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     338.14|     113|     324|    1061|    1185|       2
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 1061- 1185 (162.18/164.05)	PNLTGLRvELLQLLVPLIS.GKSKYADLVTYRFHVAQqeFFlKHPQETLDI.ICDAVAL....VDSKAGLDSRQPDIA..GCAiellDILLTQNPEVtVQYCLEG.FIgkYSTSTTVLQRALDSLLGfDSLAGP
 1388- 1509 (175.97/131.91)	PKPNGLQ.EQSRLLISILCiSLARLPDSVIRLFPATD..YF.PHPIPSQGCrACPGILLqthaLDVAASLIDTFPDEArqHCA....RFLKEKCPPF.LQYQNDSrFI..YLLGPMSDAAALNSLQA.ASLPSP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.63|      24|      35|     442|     476|       3
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  423-  446 (42.77/49.65)	GWFLSSLEAAPVNTVPVWLLMLGI
  458-  481 (36.86/16.42)	GRRLAELLLEKLRQVSALVLMVNI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     600.55|     204|     234|     565|     798|       4
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  565-  798 (295.19/261.94)	GTAERSPQQrviqlFDSIRSA....HDIsSASAACLK..TLEDKAVLISKLLEWTATPFRyGLCRVYTGVRLLRkwkmsGIdVDSYI.LSFLADVRVTSALNM.ENIYHIISELvrsQTFSVGRY.LQWLMAKGVTNTSQPVSSDLCL.LKQLPanrlPEHVRNLRNTLLYRAGIPVMEEDSA......IAELKLSIAQRLPNIFGAEMGSAMPIEPSQANpTWAVKseigqWIrrgvAGHYRDSPRKLS
  807- 1026 (305.37/196.15)	GVSALTPDE.....FYSVREIletyGDL.SMLADILKqaTRCDDDVVLASVADTVNCHFD.CFCVIGATADLFR.....GL.VESYArLKRLGNASLDLLFSLiELGLRIPSEF...NTVALLRQdLTRLESKSALAAPSPLSDSIPLaLSDVD....PSFQAKLNQLLSSGSGMDESTMDAVfyslihILESSGSPAKLSANETARYLAYLRPFQPKHFD.TMLIR.....WI....CGLLKSSTPSMS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.37|      17|      35|      27|      45|       5
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   27-   45 (25.56/20.89)	DAsQAVGPPdPQFEKLPTP
   65-   81 (32.81/17.01)	DA.QEVEPP.PKRLRLDLP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.63|      25|      37|     360|     384|       6
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  360-  384 (43.28/30.05)	TSGTLALGLEAKWVRDWTATVQQFL
  398-  422 (42.35/29.23)	TKMTYAVSLTARLFFERLLDHDQYL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.83|      23|      40|     278|     300|       7
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  278-  300 (42.16/28.52)	TVPSTFKPPPRVTLTDNK.....REAWL
  316-  343 (35.67/22.79)	TIPHGIRGKALLDQCLNKgipvsRAVWL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.68|      18|      19|    1342|    1359|       9
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 1342- 1359 (31.05/23.85)	ANRHGAATTQILQSRSNF
 1364- 1381 (32.63/25.51)	AFWFSAFLRMIVIHRSAF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10350 with Med12 domain of Kingdom Fungi
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