<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10348

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWGAFLHQSLMRRIDATEFKTLSKILFRRCPIAEGTLLDVLLEIRLATGIKWDPLLPLYIDCLCKMGKVQTSTVLISLLKYSSIHDKPQSPGSGAVQSKNALKCYTLMTDIRVIQDAMLSVSTGSTPKSLAEAVGIFSAIIDWIQAVVAWHNNHIDPNQQTGGLMSSPDAVSLFESLGILLTALSGTGKGIEVLSSDSHEALKVKLGQALSAYLPLCMEVSLPLRNRLDSLQKGFNLYGEPPNKSLQSMMDNVNVNALQFEASVMDGPVINSRAGLYIYINAMLVGRPLVDDSMLLNYLTNRYGGHYDVLVEEVIAATFDVLSNALYRNESSRTMFMFRSFLVNKLPSFFAAMMAASMVSLPMEMCISHALSRLDPNTFPSFSQMFAMQGSTVLSEVRPEFLFACASHKLIPESSIERLLGENPMQTPPVGYNKDDLVSQINTNQERAEQLVSELESTEGNAGAIVAAITEVMHNLCNQKETMTLKSICSSLSRRPQSLDVILLFRSAKQVLQPLCTLLDSWHWDEDQGESQPVYDEFGSILLLILTFKYRYDLRPYDLGITSNDSFILKLLDCGASSQKLDDLSEKQNKNLGAWITALFIAEGISEETMSSCSPQEFYLLVTTLFNQSLTACEAGKLEFDTLKGGFEYLLEPFLLPSLVVALTWLGNHIWETESDPTIPLKTLQSLVNPSSISGDAREIHKTVLNIAARSLDEQLKDIRSRHPNRADIKPILDVLEPCLSFQRTGSCHRSELDSWTTHSPGGLLGSIRSTFQGLVLWSTSPGVSMAPHSYTHRQLVAGIRMLGSTRVLTAIVDELKVQTETGNADLALDIAVTMICAPLAESFAVEQSNYHPVDPNKESLPRCPILTLRDALNLQHENVPKLSEKDPLRAEVIVRLYRRVNALMTPTSQMPNLDMSNIIQNMQLGVEDHGQMDLEPTGAGHGVGDDDAANLNRMLDNAAAAAAAGLDSGMGQSMGGALDTSIDDVLNAADMAVGNPEFLDLDMEGMF
Length1013
PositionTail
OrganismAspergillus bombycis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.021
Instability index49.46
Isoelectric point4.94
Molecular weight111280.25
Publications
PubMed=27664179

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10348
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.59|      28|     296|       5|      33|       1
---------------------------------------------------------------------------
    5-   33 (44.94/42.02)	EQWGAFlHQSLMRRIDATEFKTLSKILFR
  306-  333 (47.65/38.84)	NRYGGH.YDVLVEEVIAATFDVLSNALYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.71|      12|      42|     130|     141|       3
---------------------------------------------------------------------------
  130-  141 (21.26/11.59)	STPK..SLAEAVGI
  171-  184 (17.45/ 8.26)	SSPDavSLFESLGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.34|      47|     598|      51|      99|       4
---------------------------------------------------------------------------
   51-   99 (77.77/54.48)	LATGIKW..DP.LLPLYIDCLCKMGK..VQT.STVLISLLKYSSIHDkPQSPgSG
  648-  700 (66.58/38.23)	LKGGFEYllEPfLLPSLVVALTWLGNhiWETeSDPTIPLKTLQSLVN.PSSI.SG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     221.01|      69|     670|     215|     289|       6
---------------------------------------------------------------------------
  215-  289 (108.48/93.81)	LSAYLPLCMEVSLPLRNRLDSLQKGfnlYGEPPNKSLQSMMDNVNV.....NALQFEASVMDGPVINSRAGlyiYINAML
  888-  961 (112.53/79.75)	LSEKDPLRAEVIVRLYRRVNALMTP...TSQMPNLDMSNIIQNMQLgvedhGQMDLEPTGAGHGVGDDDAA...NLNRML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.34|      56|     231|     490|     548|       8
---------------------------------------------------------------------------
  490-  548 (94.74/57.60)	LKSICSslsRRPQSLDVILLFRSAKQVLQ....PLC..TLLDSWHWDEDQGESQPVYDEFGSILL
  721-  782 (88.61/47.72)	LKDIRS...RHPNRADIKPILDVLEPCLSfqrtGSChrSELDSWTTHSPGGLLGSIRSTFQGLVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.16|      11|     831|      34|      46|       9
---------------------------------------------------------------------------
   34-   46 (17.00/14.64)	RCPIAegTLLDVL
  868-  878 (22.16/11.75)	RCPIL..TLRDAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10348 with Med5 domain of Kingdom Fungi
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