<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10333

Description Uncharacterized protein
SequenceMIPQSSGQPWGPSLRTVNGPGRVENAMLGHDHLDRPMPQPPIRPAVVDLTAGGPESQDREPPPKRPRLDVPGGSNATDTGATMSAEARSAPGSATPRPTVSWRGRPLWSFQAVVSELPNNENRGDGTGSKPPSPPPLPAQPWEIPAVEPPATTVVKSRESSPVGAVQTTPYRIETPSAAPVYKNQKPADFTPWTGNHPEDILNEQTAKQGYYDRTQVSQNESNTARPALYAQLKHRTGLQMLSSVFAAALEKRQNHNTIHAPSTFKPPPRVTLTDNKREGWLRDLANPTVPLRRLSRTIPHGIRGKVLLDQCLGKWIPVARAVWLAKCVGANEIRAFKRKGTSGALAVGLEAKWVREWTANVQQFVEGVFSAPKSSDWKAKMTYAVGLTARLFFENLLDHDHFLEWFLTSFEAASLGTIPVWLLMLGVYWNSIMRYRRRGRRLAELLLEKLRQANEAKLASLQPLIDRLARFIKRLVCDHTPSMILPNTWETYKQQVSSVLDLEKACEKALFQNLAERNARVQRPNHSKQTNNRSPHQRIIRHLDSIRSAHDISSMSSYFDTFEDKAELVSKLLEWLSTPFRHGLCRVYIGARLLRKWKSAGVDIDSHILAFLSRGRNNQKLNMDQIYHVISELVRSQTFSVGRYLQWLMARGVTNSPSITDHYIKDLPIDIGLIAQLPVGRLPEHVANLRNTLQTRTGLSVSEEYAVIDNVKEIISQRLPGIFGDNARTTMAVDSLPSSLTWAVKAEIGQWLRRAIAQHNRNAAESTTAAFPAGAVPVVSALTPTEIYIVRDILESFGDISMLADVLNFASSCTDSTVLASVADTTNCHFDSLCVIGATTDLFRRLIDAYAGIKRFGVPGLDLVFSLIELGLRIPSEVNTVAILRQDLSRMENKSIMAAYSPVSDHIPDNFGDTDPFLREKLDQILLTGNVMDEPTLDAIFSALTKHLEAEEGHSKLSANDTCRYLAQLRSFHPKHFDVILARWVCGHLRSPDRTTLLRILPPLIGVGCVTIRAFLALAMRLALSTPAKIPNTAHLPADLVQLLLPSTKENRRFDLVSYRFQLAQQEFLTKNTEEALKIVCDAAASANTGDDAPAKYSDLENSMVILLRDLLVRKPECVAQKCMQKLAEQYPAALGMVQKALDLLLGIDSHSDGKSVLSEIEKLASMTDDFSLPFCQLKLQVLFHADSGTEDRNSIVDAMFKTAVADSRAHRLHWVDLVALMSPDAVRQIRERAEKEFFSVPLLEDSTSDTPDQPDKLGPLETAKLYLTIIEELAGSVPESGTSSVGSVLVEKMDALLHKIITMHSTLVNTQSTASQTRSKFERGLAFWFSALLRMVVIHRSAFIHQPQTLKPNPPHDQLRLLISIFCIALSRLPGNVLRLFPAADYFPHPTSTPEDYRPCPGILLQTHALDVAASLIDIFSDEVRFQCARFLKEKCPSFVPFQNDSRFLYLLGPTPDQSSVNPQHVSAPSPAASASTPTPTPAPFPAVGASAAQQSAVAASSLSSGYPDDTNCMASRLRLQHRGRVVGPYPVRPWELLEDAAPFVGVNDTAVNLGYFDARRVRA
Length1566
PositionKinase
OrganismPenicillium arizonense
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.218
Instability index47.24
Isoelectric point8.59
Molecular weight173404.27
Publications
PubMed=27739446

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10333
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.23|      19|      19|      40|      58|       1
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   12-   34 (27.79/13.35)	PSLRtvngPGRVENAMLGHDHLD
   40-   58 (34.58/18.53)	PPIR....PAVVDLTAGGPESQD
   62-   78 (31.86/16.45)	PPKR....PR.LDV.PGGSNATD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.74|      57|     162|     393|     483|       2
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  403-  483 (82.61/107.56)	FLEWFLTSFEAaslGTIPVWllmLGVY....WNS........IMRYRRRGRrlaellleklrqaNEAKLAslqplIDRLARFIKRLVCDHTPS
  573-  641 (93.13/51.43)	LLEWLSTPFRH...GLCRVY...IGARllrkWKSagvdidshILAFLSRGR.............NNQKLN.....MDQIYHVISELVRSQTFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.56|      28|      37|      86|     113|       3
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   86-  113 (50.50/29.05)	EAR.SAP.GS..ATPRPTVSWRGRPLWSFQAV
  121-  147 (48.54/27.57)	ENR.GDG.TG..SKPPSPPPLPAQP.WEIPAV
  156-  185 (24.53/ 9.45)	KSReSSPvGAvqTTPYRIETPSAAPVYKNQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.65|      20|      21|    1187|    1206|       4
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 1167- 1183 (23.81/12.72)	..SMTDDF...SLPFCQLKLQV
 1187- 1206 (32.97/20.69)	ADSGTEDRN..SIVDAMFKTAV
 1207- 1228 (26.87/15.39)	ADSRAHRLHwvDLVALMSPDAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.31|      30|      35|     700|     733|       5
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  700-  733 (45.75/37.00)	LSVSEEYAvidnVKEIISQRLPGIFGDNAR.....TTMA
  737-  771 (47.57/28.75)	LPSSLTWA....VKAEIGQWLRRAIAQHNRnaaesTTAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.15|      13|      15|     300|     314|       6
---------------------------------------------------------------------------
  300-  314 (19.39/17.71)	PhgIRGKVLLDQCLG
  318-  330 (24.76/14.12)	P..VARAVWLAKCVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.89|      20|     203|    1236|    1255|       7
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 1236- 1255 (37.02/22.92)	EKEFFSVPLLEDS.....TSDTPDQ
 1436- 1460 (34.87/21.11)	EKCPSFVPFQNDSrflylLGPTPDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.69|      11|      15|     797|     807|       8
---------------------------------------------------------------------------
  797-  807 (19.57/14.21)	SFGDISMLADV
  813-  823 (19.11/13.67)	SCTDSTVLASV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.86|      11|      37|     347|     357|       9
---------------------------------------------------------------------------
  347-  357 (20.38/12.76)	AVGLEAKWVRE
  385-  395 (19.48/11.85)	AVGLTARLFFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.44|      10|      15|     203|     212|      13
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  203-  212 (18.22/11.99)	NEQTAKQGYY
  221-  230 (17.22/10.89)	ESNTARPALY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.47|      19|      37|    1297|    1315|      15
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 1297- 1315 (30.99/19.99)	ALLHKIITMHSTLVNTQST
 1333- 1351 (32.48/21.30)	ALLRMVVIHRSAFIHQPQT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10333 with Med12 domain of Kingdom Fungi
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