<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10331

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDNVNIDGSVRPPGLDEARNGESNSLGNVDKAAQMPSSMNGSAHVNGASSVVDALNQTSATLAGKAGGKVPTTPFELTHITQGFFPFGTLVNRSVQQCWNELSELITELAAIQVPQQAALGTTNGKAPGNQSSENVHKKLRLLDFAHAKRAEFIKLLVLSQWSRQAADVSRLIDIQGFIRTRHQSYDAALQYVGEVKRDLVRAQVANPDLKTALLVLSKGQVASLPDLGYSPLKPLTARATLKKLLKLNRIISVRLALHDSVPHALRHYRVHDGRVTFTVPGEFELDLSVAEVSTTSQFFFVDIRFLFSPSSPIPEGRILNELDAKINETLRNDGLMGCFNFLHGLVLTNKINILFRQAADLARGLWADALRIELLHRTLVVQYWPQRAGPKSWLEIGVNSGHRSSKSSNLMSGISHLGFRWMREGQLTISDAVKFDTDDLSMERILRSVVALHTSHLLSAAFTALKKHLLFAKHTLSLQALLSSTEPGDCHLDVQLTTSRSVRVSIEPMSGSIILCVTPNVPERLDTDRTVHKSSIEEILTRVARLRCATAVEEIESGTKALGLETVSQRVLGLDPRKLFPPGVMRSAFFFHQLWNRQWVAAATSSMDGDRWWLVQLRPTGTTRATPPYSLGENGITLPCAHVISESLVSAQRLLDYTTCAELVHGLTGILAIHANACYLAELPALRFWPPLKELQMDSDLTVPDLLFSYNPSTLPPALRIALPSGVNRQSQLKEMVRLAFHGIDRKSRSIIMVAHGTLRNRIKSLVPLISKTDPSLITEDKGAGFALRLLVPAGNSVIVGLFERLQRLECVLSILQSLILNGMEPRSLSLSQIAFAYGTETKSSASFDIGVSGPTVSDYVDMAAISKSQPLFRLQLGIKFESSSPHRRIQEALAVALNHRFTETGVKSVLHLMSFTFPLLRSFDQITNLSNQTDSSIVYITVRKPTDYHIHYPRLNSRFRLNRILHQDEQVWMLRDANKDNQSGRGQIATAIREKLYQSKGDGWNGLGDGAVGMPDKVGNLLVELHQCLSAPHLELDKEAEGKAAIPEPLLTKGPVSALPNKTASNQASGLGDTDIITID
Length1087
PositionTail
OrganismPenicillium arizonense
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.090
Instability index43.94
Isoelectric point9.03
Molecular weight119523.79
Publications
PubMed=27739446

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10331
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     103.62|      21|      68|     432|     452|       1
---------------------------------------------------------------------------
  432-  452 (31.32/20.73)	QLTISDAVKFD..TDDLSMERIL
  501-  521 (28.46/18.13)	QLTTSRSVRVS..IEPMSGSIIL
  524-  546 (23.82/13.91)	TPNVPERLDTDrtVHKSSIEEIL
  554-  573 (20.02/10.46)	CATAVEEIESG..TKALGLETV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.46|      67|     567|     247|     367|       3
---------------------------------------------------------------------------
  296-  367 (101.70/124.44)	AEVSTTSQFFFVDIRFLFSPSSpiPEGRILNELDAKINETLRNDGLMgcfNFLHGLVLTNKINILFRQAADL
  870-  936 (111.77/47.31)	AAISKSQPLFRLQLGIKFESSS..PHRRIQEALAVALNHRFTETGVK...SVLHLMSFTFPLLRSFDQITNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.72|      28|     561|      17|      46|       4
---------------------------------------------------------------------------
   17-   46 (46.88/41.34)	PPGLdeARNG.ESNSLGNVDKAAQMPSSMNG
  587-  615 (50.84/37.31)	PPGV..MRSAfFFHQLWNRQWVAAATSSMDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.07|      17|      55|     161|     183|       8
---------------------------------------------------------------------------
  161-  183 (18.91/24.73)	LLVLSQwsrqaADVSRLIDIqGF
  219-  235 (30.16/15.99)	LLVLSK.....GQVASLPDL.GY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10331 with Med14 domain of Kingdom Fungi
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