<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10326

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMAAQGAPMEEIMWRSPPHVQMMGGFLHSNNILFYFAESPFFDATSNNASLAIQANYNEAFRHFVETREAFEGRLKTMQGLEFVVSYDPLQAAAQTDTSFAHEPSNIWVIRKQNRRKRSGFEDEVSVISTFFVVGDAIYMAPSVASVVGNRILSAVTSLSRFMKTASTLPTFTPSYGHTYMPPGARSKEPNQQSSQQSKESTPMPDAPSDTQSISKTNLGVSATTPNYQDTRSLAESFNLLTRYGDEFMDENPLAGEPGSFILSRTGGEGGGAGKQAAPKTGAGPSSLSVPASGPPGRATTPQVRVETPKGSDKGASPPSSGGDRGKRKKSRNVV
Length334
PositionHead
OrganismPenicillium arizonense
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.517
Instability index56.86
Isoelectric point8.69
Molecular weight35918.62
Publications
PubMed=27739446

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
	RuleBase:RU364143
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP10326
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.97|      20|      20|     227|     246|       1
---------------------------------------------------------------------------
  209-  228 (25.55/12.71)	DTQSIS...KT.NLgVSATTPNYQ
  229-  248 (35.68/20.09)	DTRSLA...ESFNL.LTRYGDEFM
  249-  268 (19.74/ 8.48)	DENPLAgepGSF.I.LSRTGGE..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.22|      28|      38|     118|     153|       2
---------------------------------------------------------------------------
  118-  145 (47.91/34.01)	SGFEDEVSVISTFFVVGDAIYMAPSVAS
  159-  186 (53.32/23.89)	SRFMKTASTLPTFTPSYGHTYMPPGARS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.42|      19|      47|      33|      51|       3
---------------------------------------------------------------------------
   33-   51 (30.23/18.00)	FYFAESPFFDATSNNASLA
   63-   81 (27.95/16.14)	FVETREAFEGRLKTMQGLE
   82-  100 (29.23/17.19)	FVVSYDPLQAAAQTDTSFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.23|      23|      24|     275|     297|       4
---------------------------------------------------------------------------
  275-  297 (40.80/21.96)	QAAPKTGAGPSSLSVPASGPPGR
  302-  324 (40.43/21.69)	QVRVETPKGSDKGASPPSSGGDR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10326 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NLLTRYGDEFMDENPLAGEPGSFILSRTGGEGGGAGKQAAPKTGAGPSSLSVPASGPPGRATTPQVRVETPKGSDKGASPPSSGGDRGKRKKSRNVV
2) TPSYGHTYMPPGARSKEPNQQSSQQSKESTPMPDAPSDTQSISKTNLGVSATTPNYQDTRSLAES
238
172
334
236










Molecular Recognition Features






MoRF SequenceStartStop




1) PQVRVETPKGSDKGASPPSSGGDRGKRKKSRNVV
301
334